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Forskningsgruppe for translasjonsforskning; biomarkørerer og molekylærgenetikk på Lovisenberg Diakonale Sykehus

Forskningsgruppe-bilde

Forskningsgruppeinfo

Deltakere

Kaare M Gautvik
Sjur Reppe
Einar Lindalen
Karl Johnny Kvernevik
Haldor Valland
Anners Vetle Lerdal
Vigdis Teig Gautvik
Ole Kristoffer Olstad
Anne Runningen

Kontakt

Lovisenberg Diakonale Hospital
Lovisenberggt. 17
0440 Oslo
post@lds.no


Forskningsgruppeleder

Kaare M Gautvik
Sjur Reppe

Ansvarlig enhet(er)

Beskrivelse

The skeleton is an organ which is frequently affected by primary and secondary diseases. Among the primary diseases are osteoporosis and osteoarthritis whose causes are mainly unknown, but both have a strong genetic component. The main purpose is to make the skeleton the first human organ where we fully recognize the macromolecular composition. This novel knowledge of bone modelling and metabolism will lay the basis for development of better diagnostic tools and treatment regimes. The group is also involved in projects within clinical immunology and associated biomarkers and epigenetics.

Publikasjoner

Meta-Analysis of Genome-Wide Scans for Total Body BMD in Children and Adults Reveals Allelic Heterogeneity and Age-Specific Effects at the WNT16 Locus (2012)
Medina-Gomez, Carolina;Kemp, John P.;Estrada, Karol;Eriksson, Joel;Liu, Jeff;Reppe, Sjur;Evans, David M.;Heppe, Denise H.M.;Vandenput, Liesbeth;Herrera, Lizbeth;Ring, Susan M.;Kruithof, Claudia J.;Timpson, Nicholas J.;Zillikens, M. Carola;Olstad, Ole Kristoffer;Zheng, Hou-Feng;Richards, J. Brent;Pourcain, Beate St.;Hofman, Albert;Jaddoe, Vincent W.V.;Smith, George Davey;Lorentzon, Mattias;Gautvik, Kaare M;Uitterlinden, André G.;Brommage, Robert;Ohlsson, Claes;Tobias, Jonathan H.;Rivadeneira, Fernando
PLoS Genetics
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture (2012)
Estrada, Karol;Styrkarsdottir, Unnur;Evangelou, E;Hsu, YH;Duncan, EL;Ntzani, EE;Oei, L;Albagha, OME;Amin, N;Kemp, JP;Koller, DL;Li, G;Liu, CT;Minster, RL;Moayyeri, A;Vandenput, L;Willner, D;Xiao, SM;Yerges-Armstrong, LM;Zheng, HF;Alonso, N;Eriksson, J;Kammerer, CM;Kaptoge, SK;Leo, PJ;Thorleifsson, G;Wilson, SG;Wilson, JF;Aalto, V;Alen, M;Aragaki, AK;Aspelund, T;Center, JR;Dailiana, Z;Duggan, DJ;Garcia, M;Garcia-Giralt, N;Giroux, S;Hallmans, G;Hocking, LJ;Husted, LB;Jameson, KA;Khusainova, R;Kim, GS;Kooperberg, C;Koromila, T;Kruk, M;Laaksonen, M;Lacroix, AZ;Lee, SH;Leung, PC;Lewis, JR;Masi, L;Mencej-Bedrac, S;Nguyen, TV;Nogues, X;Patel, MS;Prezelj, J;Rose, LM;Scollen, S;Siggeirsdottir, K;Smith, AV;Svensson, O;Trompet, S;Trummer, O;van Schoor, NM;Woo, J;Zhu, K;Balcells, S;Brandi, ML;Buckley, BM;Cheng, SL;Christiansen, C;Cooper, C;Dedoussis, G;Ford, I;Frost, M;Goltzman, D;Gonzalez-Macias, J;Kahonen, M;Karlsson, M;Khusnutdinova, E;Koh, JM;Kollia, P;Langdahl, BL;Leslie, WD;Lips, P;Ljunggren, O;Lorenc, RS;Marc, J;Mellstrom, D;Obermayer-Pietsch, B;Olmos, JM;Pettersson-Kymmer, U;Reid, DM;Riancho, JA;Ridker, PM;Rousseau, F;Slagboom, PE;Tang, NLS;Urreizti, R;Van Hul, W;Viikari, J;Zarrabeitia, MT;Aulchenko, YS;Castano-Betancourt, M;Grundberg, E;Herrera, L;Ingvarsson, T;Johannsdottir, H;Kwan, T;Li, R;Luben, R;Medina-Gomez, C;Palsson, ST;Reppe, Sjur;Rotter, JI;Sigurdsson, G;van Meurs, JBJ;Verlaan, D;Williams, FMK;Wood, AR;Zhou, YH;Gautvik, Kaare M;Pastinen, T;Raychaudhuri, S;Cauley, JA;Chasman, DI;Clark, GR;Cummings, SR;Danoy, P;Dennison, EM;Eastell, R;Eisman, JA;Gudnason, V;Hofman, A;Jackson, RD;Jones, G;Jukema, JW;Khaw, KT;Lehtimaki, T;Liu, YM;Lorentzon, M;McCloskey, E;Mitchell, BD;Nandakumar, K;Nicholson, GC;Oostra, BA;Peacock, M;Pols, HAP;Prince, RL;Raitakari, O;Reid, IR;Robbins, J;Sambrook, PN;Sham, PC;Shuldiner, AR;Tylavsky, FA;van Duijn, CM;Wareham, NJ;Cupples, LA;Econs, MJ;Evans, DM;Harris, TB;Kung, AWC;Psaty, BM;Reeve, J;Spector, TD;Streeten, EA;Zillikens, MC;Thorsteinsdottir, U;Ohlsson, C;Karasik, D;Richards, JB;Brown, MA;Stefansson, K;Uitterlinden, AG;Ralston, SH;Ioannidis, JPA;Kiel, DP;Rivadeneira, F
Nature Genetics
Identification of transcriptional macromolecular associations in human bone using browser based in silico analysis in a giant correlation matrix (2013)
Reppe, Sjur;Sachse, Daniel;Olstad, Ole Kristoffer;Gautvik, Vigdis Teig;Sanderson, Paul;Datta, Harish K;Berg, Jens Petter;Gautvik, Kaare M
Bone
Skrøpelige ben-hvordan oppstår de og hva kan vi gjøre? (2012)
Reppe, Sjur;Gautvik, Kaare M
Osteoporose
Enamel Matrix Derivative Promote Primary Human Pulp Cell Differentiation and Mineralization (2014)
Riksen, Elisabeth Aurstad;Landin, Maria Augusta Dos S Silva;Reppe, Sjur;Nakamura, Yoikio;Lyngstadaas, Ståle Petter;Reseland, Janne Elin
International Journal of Molecular Sciences
Phenotypic Dissection of Bone Mineral Density Reveals Skeletal Site Specificity and Facilitates the Identification of Novel Loci in the Genetic Regulation of Bone Mass Attainment (2014)
Kemp, John P.;Medina-Gomez, Carolina;Estrada, Karol;St Pourcain, Beate;Heppe, Denise H.M.;Warrington, Nicole M;Oei, Ling;Ring, Susan M.;Kruithof, Claudia J.;Timpson, Nicholas J.;Wolber, Lisa E.;Reppe, Sjur;Gautvik, Kaare M;Grundberg, Elin;Ge, Bing;van der Eerden, Bram;van de Peppel, Jeroen;Hibbs, Matthew A.;Ackert-Bicknell, Cheryl L.;Choi, Kwangbom;Koller, Daniel L.;Econs, Michael J.;Williams, Frances M.K.;Foroud, Tatiana;Zilikens, M.Carola;Ohlsson, Claes;Hofman, Albert;Uitterlinden, André G.;Smith, George Davey;Jaddoe, Vincent W.V.;Tobias, Jonathan H.;Rivadeneira, Fernando;Evans, David M.
PLoS Genetics
Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes (2014)
Andreassen, Ole Andreas;McEvoy, Linda K.;Thompson, Wesley K.;Wang, Yunpeng;Reppe, Sjur;Schork, Andrew J.;Zuber, Verena;Barrett-Connor, Elizabeth;Gautvik, Kaare M;Aukrust, Pål;Karlsen, Tom Hemming;Djurovic, Srdjan;Desikan, Rahul S.;Dale, Anders
Hypertension
The C-terminal domain of chondroadherin: A new regulator of osteoclast motility counteracting bone loss (2014)
Capulli, Mattia;Olstad, Ole Kristoffer;Önnerfjord, Patrik;Tillgren, Viveka;Muraca, Maurizio;Gautvik, Kaare M;Heinegård, Dick;Rucci, Nadia;Teti, Anna
Journal of Bone and Mineral Research
Methylation of bone SOST, its mRNA, and serum sclerostin levels correlate strongly with fracture risk in postmenopausal women (2015)
Reppe, Sjur;Noer, Agate;Grimholt, Runa Marie;Halldorsson, Bjarni V;Medina-Gomez, Carolina;Gautvik, Vigdis Teig;Olstad, Ole Kristoffer;Datta, Harish K;Berg, Jens Petter;Estrada, Karol;Hofman, Albert;Uitterlinden, André G.;Rivadeneira, Fernando;Lyle, Robert;Collas, Philippe;Gautvik, Kaare M
Journal of Bone and Mineral Research
Har årsakene til det perimenopausale bentap hos kvinner blitt funnet?". (2015)
Reppe, Sjur;Gautvik, Vigdis T;Gautvik, Kaare M
Osteoporose
The α2β1 binding domain of chondroadherin inhibits breast cancer-induced bone metastases and impairs primary tumour growth: A preclinical study (2015)
Rucci, Nadia;Capulli, Mattia;Olstad, Ole Kristoffer;Önnerfjord, Patrik;Tillgren, Viveka;Gautvik, Kaare M;Heinegård, Dick;Teti, Anna
Cancer Letters
Effect of Storage Temperature on the Phenotype of Cultured Epidermal Cells Stored in Xenobiotic-Free Medium (2016)
Jackson, Catherine;Eidet, Jon Roger;Reppe, Sjur;Aass, Hans Christian;Tønseth, Kim Aleksander;Roald, Borghild;Lyberg, Torstein;Utheim, Tor Paaske
Current Eye Research
The influence of DNA methylation on bone cells (2015)
Reppe, Sjur;Datta, Harish K.;Gautvik, Kaare M
Current Genomics
Genetic sharing with cardiovascular disease risk factors and diabetes reveals novel bone mineral density loci (2015)
Reppe, Sjur;Wang, Yunpeng;Thompson, Wesley K.;McEvoy, Linda K.;Schork, Andrew J.;Zuber, Verena;LeBlanc, Marissa;Bettella, Franscesco;Mills, Ian Geoffrey;Desikan, Rahul S.;Djurovic, Srdjan;Gautvik, Kaare M;Dale, Anders;Andreassen, Ole Andreas
PLOS ONE
The Silk-protein Sericin Induces Rapid Melanization of Cultured Primary Human Retinal Pigment Epithelial Cells by Activating the NF-κ B Pathway (2016)
Eidet, Jon Roger;Reppe, Sjur;Pasovic, Lara;Olstad, Ole Kristoffer;Lyberg, Torstein;Khan, Ayyad Ahmad Zartasht;Fostad, Ida Grunnan;Chen, Dong Feng;Utheim, Tor Paaske
Scientific Reports
Nucleus Morphometry in Cultured Epithelial Cells Correlates with Phenotype (2016)
Khan, Ayyad Ahmad Zartasht;Utheim, Tor Paaske;Jackson, Catherine;Reppe, Sjur;Lyberg, Torstein;Eidet, Jon Roger
Microscopy and Microanalysis
Tilting the lasso by knowledge-based post-processing (2016)
Tharmaratnam, K.;Sperrin, M.;Jaki, T.;Reppe, Sjur;Frigessi, Arnoldo
BMC Bioinformatics
Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2 (2016)
Nielson, CM;Liu, CT;Smith, AV;Ackert-Bicknell, CL;Reppe, Sjur;Jakobsdottir, J;Wessel, Christina;Register, Thomas C;Oei, Ling;Alonso, Nerea;Oei, Edwin H;Parmi, Neeta;Samuelson, Elisabeth;Nalls, Mike A;Zmuda, Joseph;Lang, Thomas;Bouxsein, Mary;Latourelle, Jeanne;Claussnitzer, Melina;Siggeirsdottir, Kristin;Srikanth, Priya;Lorentzen, Erik;Vandenput, Liesbeth;Langefeld, Carl;Raffield, Laura;Terry, Greg;Cox, Amanda J;Allison, Matthew A;Criqui, Michael H;Bowden, Don;Ikram, M Arfan;Mellstrøm, Dan;Karlsson, Magnus K.;Carr, John;Budoff, Matthew;Phillips, Caroline;Cupples, Adrienne;Chou, Wen-Chi;Myers, Richard H;Ralston, Stuart H;Gautvik, Kaare M;Cawthon, Peggy M;Cummings, Steven;Karasik, David;Rivadeneira, Fernando;Gudnason, Vilmundur;Orswoll, Eric S;Harris, Tamara B;Ohlsson, Claes;Kiel, Douglas P.;Hsu, Yi-Hsiang
Journal of Bone and Mineral Research
Omics analysis of human bone to identify genes and molecular networks regulating skeletal remodeling in health and disease (2017)
Reppe, Sjur;Datta, Harish K.;Gautvik, Kaare M
Bone
Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus (2017)
Medina-Gomez, Carolina;Kemp, John P.;Dimou, Niki L.;Kreiner, Eskil;Chesi, Alessandra;Zemel, Babette S.;Bønnelykke, Klaus;Boer, Cindy G.;Ahluwalia, Tarunveer Singh;Bisgaard, Hans;Evangelou, Evangelos;Heppe, Denise H.M.;Bonewald, Lynda F.;Gorski, Jeffrey P.;Ghanbari, Mohsen;Demissie, Serkalem;Duque, Gustavo;Maurano, Matthew T.;Kiel, Douglas P.;Hsu, Yi-Hsiang;Van Der Eerden, Bram C.J.;Ackert-Bicknell, Cheryl;Reppe, Sjur;Gautvik, Kaare M;Raastad, Truls;Karasik, David;van de Peppel, Jeroen;Jaddoe, Vincent W.V.;Uitterlinden, André G.;Tobias, Jonathan H.;Grant, Struan F.A.;Bagos, Pantelis G.;Evans, David M.;Rivadeneira, Fernando
Nature Communications
Distinct DNA methylation profiles in bone and blood of osteoporotic and healthy postmenopausal women (2017)
Reppe, Sjur;Lien, Tonje Gulbrandsen;Hsu, Yi-Hsiang;Gautvik, Vigdis Teig;Olstad, Ole Kristoffer;Yu, Rona;Bakke, Hege Gilbø;Lyle, Robert;Kringen, Marianne K.;Glad, Ingrid Kristine;Gautvik, Kaare M
Epigenetics
Optimization of storage temperature for Retention of Undifferentiated cell character of cultured human epidermal cell sheets (2017)
Jackson, Catherine;Reppe, Sjur;Eidet, Jon Roger;Eide, Lars;Tønseth, Kim Alexander;Bergersen, Linda Hildegard;Dartt, Darlene A.;Griffith, May;Utheim, Tor Paaske
Scientific Reports
Genetic Polymorphism of miR-196a-2 is Associated with Bone Mineral Density (BMD). (2017)
Karabegović, I;Maas, S.M.;Medina-Gomez, Carolina;Zrimšek, M;Reppe, Sjur;Gautvik, Kaare M;Uitterlinden, AG;Rivadeneira, F;Ghanbari, M
International Journal of Molecular Sciences
Integrated analysis of DNA-methylation and gene expression using high-dimensional penalized regression: a cohort study on bone mineral density in postmenopausal women (2018)
Lien, Tonje Gulbrandsen;Borgan, Ørnulf;Reppe, Sjur;Gautvik, Kaare M;Glad, Ingrid Kristine
BMC Medical Genomics
Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density (2017)
Alonso, Nerea;Estrada, Karol;Albagha, Omar M E ;Herrera, Lizbeth;Reppe, Sjur;Olstad, Ole Kristoffer;Gautvik, Kaare M;Ryan, Niamh M;Evans, Kathryn L;Nielson, Carrie;Hsu, Yi-Hsiang;Kiel, Douglas P.;Markozannes, George;Ntzani, Evangelia;Evangelos, Evangelou;Feenstra, Bjarke;Liu, Xueping;Melbye, Mads;Masi, Laura;Brandi, Maria Luisa;Riches, Philip;Daroszewska, Anna;Olmos, José Manuel;Valero, Carmen;Castillo, Jesús;Riancho, José Manuel;Husted, Lise B;Langdahl, Bente L;Brown, Matthew A.;Duncan, Emma L;Kaptoge, Stephen;Khaw, Kay-Tee;Usategui-Martín, Ricardo;Del Pino-Montes, Javier;González-Sarmiento, Rogelio;Lewis, Joshua R.;Prince, Richard L.;D’Amelio, Patrizia;García-Giralt, Natalia;Nogues, Xavier;Mencej-Bedrac, Simona;Marc, Janja;Wolstein, Orit;Eisman, John A.;Oei, Ling;Medina-Gomez, Carolina;Schraut, Katharina E.;Navarro, Pau;Wilson, James F;Davies, Gail;Starr, John;Deary, Ian;Tanaka, Toshiko;Ferrucci, Luigi;Gianfrancesco, Fernando;Gennari, Luigi;Lucas, Gavin;Elosua, Roberto;Uitterlinden, Andre G;Rivadeneira, Fernando;Ralston, Stuart H
Annals of the Rheumatic Diseases
Improvement of storage medium for cultured human retinal pigment epithelial cells using factorial design (2018)
Pasovic, Lara;Utheim, Tor Paaske;Reppe, Sjur;Khan, Ayyad Ahmad Zartasht;Jackson, Catherine;Thiede, Bernd;Berg, Jens Petter;Messelt, Edvard Berger;Eidet, Jon Roger
Scientific Reports
Cultured human retinal pigment epithelial (hRPE) sheets: A search for suitable storage conditions (2018)
Khan, Ayyad Ahmad Zartasht;Utheim, Tor Paaske;Reppe, Sjur;Sandvik, Leiv;Lyberg, Torstein;Roald, Borghild;Ibrahim, Ibrahim Basim;Eidet, Jon Roger
Microscopy and Microanalysis
Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study (2018)
Trajanoska, Katerina;Morris, John A.;Oei, Ling;Zheng, Hou-Feng;Evans, David M.;Kiel, Douglas P.;Ohlsson, Claes;Richards, Brent;Rivadeneira, Fernando;Forgetta, Vincenzo;Leong, Aaron;Ahmad, Omar S.;Laurin, Charles;Mokry, Lauren E.;Ross, Stephanie;Bowden, Jack;Warrington, Nicole M.;Kleinman, Aaron;Willems, Sara M.;Wright, Daniel;Day, Felix R.;Murray, Anna;Ruth, Katherine S.;Tsidilis, Konstantinos K.;Ackert-Bicknell, Cheryl L.;Bassett, Duncan;van der Eerden, Bram;Gautvik, Kaare M;Reppe, Sjur;Williams, Graham R.
BMJ. British Medical Journal
High Throughput Screening of Additives Using Factorial Design to Promote Survival of Stored Cultured Epithelial Sheets (2018)
Reppe, Sjur;Jackson, Catherine;Ringstad, Håkon;Tønseth, Kim Alexander;Bakke, Hege Gilbø;Eidet, Jon Roger;Utheim, Tor Paaske
Stem Cells International
Meta-Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry (2019)
Hsu, Yi-Hsiang;Estrada, Karol;Evangelou, Evangelos;Ackert-Bicknell, Cheryl L.;Åkesson, Kristina;Beck, Thomas;Brown, Suzanne J.;Capellini, Terence;Carbone, Laura;Cauley, Jane;Cheung, Ching-Lung;Cummings, Steven R.;Czerwinski, Stefan;Demissie, Serkalem;Econs, Michael;Evans, Daniel;Farber, Charles;Gautvik, Kaare M;Harris, Tamara;Kammerer, Candace;Kemp, John;Koller, Daniel L.;Kung, Annie;Lawlor, Debbie;Lee, Miryoung;Lorentzon, Mattias;McGuigan, Fiona;Medina-Gomez, Carolina;Mitchell, Braxton;Newman, Anne;Nielson, Carrie;Ohlsson, Claes;Peacock, Munro;Reppe, Sjur;Richards, J. Brent;Robbins, John;Sigurdsson, Gunnar;Spector, Timothy D.;Stefansson, Kari;Streeten, Elizabeth;Styrkarsdottir, Unnur;Tobias, Jonathan;Trajanoska, Katerina;Uitterlinden, André;Vandenput, Liesbeth;Wilson, Scott G.;Yerges-Armstrong, Laura;Young, Mariel;Zillikens, Carola;Rivadeneira, Fernando;Kiel, Douglas P.;Karasik, David
Journal of Bone and Mineral Research
Elevated cytokine levels in tears and saliva of patients with primary Sjögren's syndrome correlate with clinical ocular and oral manifestations. (2019)
Chen, Xiangjun;Aqrawi, Lara Adnan;Utheim, Tor Paaske;Tashbayev, Behzod;Utheim, Øygunn Aass;Reppe, Sjur;Hove, Lene Hystad;Herlofson, Bente Brokstad;Singh, Preet Bano;Palm, Øyvind;Galtung, Hilde;Jensen, Janicke Liaaen
Scientific Reports
Mendelian randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures (2019)
Zheng, Jie;März, Winfried;Gergei, Ingrid;Kleber, Marcus;Drechsler, Christiane;Wanner, Christoph;Brandenburg, Vincent;Reppe, Sjur;Gautvik, Kaare M;Medina-Gomez, Carolina;Shevroja, Enisa;Gilly, Arthur;Park, Young-Chan;Dedoussis, George;Zeggini, Eleftheria;Lorentzon, Mattias;Henning, Petra;Lerner, Ulf H.;Nilsson, Karin H.;Movérare-Skrtic, Sofia;Baird, Denis;Elsworth, Benjamin;Falk, Louise;Groom, Alix;Capellini, Terence D.;Grundberg, Elin;Nethander, Maria;Ohlsson, Claes;Smith, George Davey;Tobias, Jonathan H.
Journal of Bone and Mineral Research


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