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Viser treff 1-50 av 58 << Forrige 1 2    Neste >>

2020
1 Nepstad, Ina; Hatfield, Kimberley Joanne; Grønningsæter, Ida Sofie; Reikvam, Håkon.
The PI3K-AKT-MTOR signaling pathway in human acute myeloid leukemia (AML) cells. International Journal of Molecular Sciences 2020 ;Volum 21:2907.(8) s. 1-22
HAUKELAND UiB Untitled
 
2019
2 Grønningsæter, Ida Sofie; Fredly, Hanne Kristin; Gjertsen, Bjørn Tore; Hatfield, Kimberley Joanne; Bruserud, Øystein.
Systemic Metabolomic Profiling of Acute Myeloid Leukemia Patients before and During Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid, Valproic Acid, and Low-Dose Chemotherapy.. Cells 2019 ;Volum 8.(10)
HAUKELAND UiB VV Untitled
 
3 Nepstad, Ina; Hatfield, Kimberley Joanne; Grønningsæter, Ida Sofie; Aasebø, Elise; Hernandez-Valladares, Maria; Hagen, Karen Marie; Rye, Kristin Paulsen; Berven, Frode; Selheim, Frode; Reikvam, Håkon; Bruserud, Øystein.
Effects of insulin and pathway inhibitors on the PI3K-Akt-mTOR phosphorylation profile in acute myeloid leukemia cells.. Signal Transduction and Targeted Therapy 2019
UiB HAUKELAND Untitled
 
2018
4 Melve, Guro Kristin; Ersvær, Elisabeth; Rye, Kristin Paulsen; Ahmed, Aymen B; Kristoffersen, Einar Klæboe; Hervig, Tor; Reikvam, Håkon; Hatfield, Kimberley Joanne; Bruserud, Øystein.
The healthy donor profile of immunoregulatory soluble mediators is altered by stem cell mobilization and apheresis. Cytotherapy 2018 ;Volum 20.(5) s. 740-754
HAUKELAND HVL UiB Untitled
 
5 Nepstad, Ina; Hatfield, Kimberley Joanne; Aasebø, Elise; Hernandez-Valladares, Maria; Brenner, Annette; Bartaula-Brevik, Sushma; Berven, Frode; Selheim, Frode; Skavland, Jørn; Gjertsen, Bjørn Tore; Reikvam, Håkon; Bruserud, Øystein.
Two acute myeloid leukemia patient subsets are identified based on the constitutive PI3K-Akt-mTOR signaling of their leukemic cells; a functional, proteomic and transcriptomic comparison. Expert opinion on therapeutic targets 2018 ;Volum 22.(7) s. 639-653
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6 Nepstad, Ina; Hatfield, Kimberley Joanne; Tvedt, Tor Henrik Anderson; Reikvam, Håkon; Bruserud, Øystein.
Clonal heterogeneity reflected by pi3k-akt-mtor signaling in human acute myeloid leukemia cells and its association with adverse prognosis. Cancers 2018 ;Volum 10:332.(9) s. 1-15
HAUKELAND UiB Untitled
 
7 Nepstad, Ina; Reikvam, Håkon; Brenner, Annette; Bruserud, Øystein; Hatfield, Kimberley Joanne.
Resistance to the antiproliferative in vitro effect of PI3K-Akt-mTOR inhibition in primary human acute myeloid leukemia cells is associated with altered cell metabolism. International Journal of Molecular Sciences 2018 ;Volum 19:382.(2) s. 1-18
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8 Reikvam, Håkon; Grønningsæter, Ida Sofie; Mosevoll, Knut Anders; Lindås, Roald; Hatfield, Kimberley Joanne; Bruserud, Øystein.
Patients with treatment-requiring chronic graft versus host disease after allogeneic stem cell transplantation have altered metabolic profiles due to the disease and immunosuppressive therapy: Potential implication for biomarkers. Frontiers in Immunology 2018 ;Volum 8:1979. s. 1-15
HAUKELAND UiB Untitled
 
2017
9 Hatfield, Kimberley Joanne; Melve, Guro Kristin; Bruserud, Øystein.
Granulocyte colony-stimulating factor alters the systemic metabolomic profile in healthy donors. Metabolomics 2017 ;Volum 13:2. s. 1-10
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2016
10 Hauge, Michelle Victoria; Bruserud, Øystein; Hatfield, Kimberley Joanne.
Targeting of cell metabolism in human acute myeloid leukemia - more than targeting of isocitrate dehydrogenase mutations and PI3K/AKT/mTOR signaling?. European Journal of Haematology 2016 ;Volum 96.(3) s. 211-221
HAUKELAND UiB Untitled
 
11 Kallekleiv, Marit Selvik; Larun, Lillebeth; Bruserud, Øystein; Hatfield, Kimberley Joanne.
Co-transplantation of multipotent mesenchymal stromal cells in allogeneic hematopoietic stem cell transplantation: A systematic review and meta-analysis. Cytotherapy 2016 ;Volum 18.(2) s. 172-185
FHI HAUKELAND HVL UiB Untitled
 
12 Reikvam, Håkon; Hatfield, Kimberley Joanne; Bruserud, Øystein.
The pretransplant systemic metabolic profile reflects a risk of acute graft versus host disease after allogeneic stem cell transplantation. Metabolomics 2016 ;Volum 12.(12)
HAUKELAND UiB Untitled
 
2015
13 Bruserud, Øystein; Nepstad, Ina; Hauge, Michelle Victoria; Hatfield, Kimberley Joanne; Reikvam, Håkon.
STAT3 as a possible therapeutic target in human malignancies: lessons from acute myeloid leukemia. Expert Review of Hematology 2015 ;Volum 8.(1) s. 29-41
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14 Reikvam, Håkon; Brenner, Annette; Hagen, Karen Marie; Liseth, Knut; Skrede, Silje; Hatfield, Kimberley Joanne; Bruserud, Øystein.
The cytokine-mediated crosstalk between primary human acute myeloid cells and mesenchymal stem cells alters the local cytokine network and the global gene expression profile of the mesenchymal cells. Stem Cell Research 2015 ;Volum 15.(3) s. 530-541
HAUKELAND UiB Untitled
 
15 Reikvam, Håkon; Grønningsæter, Ida Sofie; Ahmed, Aymen B; Hatfield, Kimberley Joanne; Bruserud, Øystein.
Metabolic serum profiles for patients receiving allogeneic stem cell transplantation: the pretransplant profile differs for patients with and without posttransplant capillary leak syndrome. Disease Markers 2015 ;Volum 2015:943430. s. -
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16 Reikvam, Håkon; Hauge, Michelle Victoria; Brenner, Annette; Hatfield, Kimberley Joanne; Bruserud, Øystein.
Emerging therapeutic targets for the treatment of human acute myeloid leukemia (part 1) - gene transcription, cell cycle regulation, metabolism and intercellular communication. Expert Review of Hematology 2015 ;Volum 8.(3) s. 299-313
HAUKELAND UiB Untitled
 
2014
17 Hatfield, Kimberley Joanne; Reikvam, Håkon; Bruserud, Øystein.
Identification of a subset of patients with acute myeloid leukemia characterized by long-term in vitro proliferation and altered cell cycle regulation of the leukemic cells. Expert opinion on therapeutic targets 2014 ;Volum 18.(11) s. 1237-1251
HAUKELAND UiB Untitled
 
18 Kvestad, Hilde; Evensen, Lasse; Lorens, James; Bruserud, Øystein; Hatfield, Kimberley Joanne.
In Vitro Characterization of Valproic Acid, ATRA, and Cytarabine Used for Disease-Stabilization in Human Acute Myeloid Leukemia: Antiproliferative Effects of Drugs on Endothelial and Osteoblastic Cells and Altered Release of Angioregulatory Mediators by Endothelial Cells.. Leukemia Research and Treatment 2014 ;Volum 2014.(143479)
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19 Lindås, Roald; Tvedt, Tor Henrik Anderson; Hatfield, Kimberley Joanne; Reikvam, Håkon; Bruserud, Øystein.
Preconditioning serum levels of endothelial cell-derived molecules and the risk of posttransplant complications in patients treated with allogeneic stem cell transplantation.. Journal of transplantation 2014 s. 1-9
HAUKELAND UiB Untitled
 
20 Reikvam, Håkon; Forthun, Rakel Brendsdal; Brenner, Annette; Ersvær, Elisabeth; Hatfield, Kimberley Joanne; Bruserud, Øystein.
Heat shock protein 90 – a potential target in the treatment of human acute myelogenous leukemia. Advances in cancer drug targets 2014 ;Volum 2. s. 3-53
UiB Untitled
 
21 Reikvam, Håkon; Tamburini, Jerome; Skrede, Silje; Holdhus, Rita; Poulain, Laury; Ersvær, Elisabeth; Hatfield, Kimberley Joanne; Bruserud, Øystein.
Antileukaemic effect of PI3K-mTOR inhibitors in acute myeloid leukaemia-gene expression profiles reveal CDC25B expression as determinate of pharmacological effect. British Journal of Haematology 2014 ;Volum 164.(2) s. 200-211
HAUKELAND UiB Untitled
 
2013
22 Reikvam, Håkon; Nepstad, Ina; Bruserud, Øystein; Hatfield, Kimberley Joanne.
Pharmacologic targeting of the PI3K/mTOR pathway controls release of angioregulators from primary human acute myeloid leukemia cells and their neighboring stromal cells. OncoTarget 2013 ;Volum 4.(6) s. 830-843
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23 Reikvam, Håkon; Nepstad, Ina; Sulen, Andre; Gjertsen, Bjørn Tore; Hatfield, Kimberley Joanne; Bruserud, Øystein.
Increased antileukemic effects in human acute myeloid leukemia by combining HSP70 and HSP90 inhibitors. Expert Opinion on Investigational Drugs 2013 ;Volum 22.(5) s. 551-563
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24 Reikvam, Håkon; Øyan, Anne Margrete; Kalland, Karl-Henning; Hovland, Randi; Hatfield, Kimberley Joanne; Bruserud, Øystein.
Differences in proliferative capacity of primary human acute myelogenous leukaemia cells are associated with altered gene expression profiles and can be used for subclassification of patients. Cell Proliferation 2013 ;Volum 46.(5) s. 554-562
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2012
25 Bruserud, Øystein; Reikvam, Håkon; Kittang, Astrid Marta Olsnes; Ahmed, Aymen B; Tvedt, Tor Henrik Anderson; Sjo, Malvin; Hatfield, Kimberley Joanne.
High-dose etoposide in allogeneic stem cell transplantation. Cancer Chemotherapy and Pharmacology 2012 ;Volum 70.(6) s. 765-782
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26 Hatfield, Kimberley Joanne; Evensen, Lasse; Reikvam, Håkon; Lorens, James; Bruserud, Øystein.
Soluble mediators released by acute myeloid leukemia cells increase capillary-like networks. European Journal of Haematology 2012 ;Volum 89.(6) s. 478-490
HAUKELAND UiB Untitled
 
27 Lee, Jungwoo; Li, Matthew; Milwid, Jack; Dunham, Joshua; Vinegoni, Claudio; Gorbatov, Rostic; Iwamoto, Yoshiko; Wang, Fangjing; Shen, Keyue; Hatfield, Kimberley Joanne; Enger, Marianne; Shafiee, Sahba; McCormack, Emmet; Ebert, Benjamin L; Weissleder, Ralph; Yarmush, Martin L; Parekkadan, Biju.
Implantable microenvironments to attract hematopoietic stem/cancer cells. Proceedings of the National Academy of Sciences of the United States of America 2012 ;Volum 109.(48) s. 19638-19643
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28 Reikvam, Håkon; Hatfield, Kimberley Joanne; Ersvær, Elisabeth; Hovland, Randi; Skavland, Jørn; Gjertsen, Bjørn Tore; Petersen, Kjell; Bruserud, Øystein.
Expression profile of heat shock proteins in acute myeloid leukaemia patients reveals a distinct signature strongly associated with FLT3 mutation status - consequences and potentials for pharmacological intervention. British Journal of Haematology 2012 ;Volum 156.(4) s. 468-480
HAUKELAND NORCE UiB Untitled
 
29 Reikvam, Håkon; Hatfield, Kimberley Joanne; Fredly, Hanne Kristin; Nepstad, Ina; Mosevoll, Knut Anders; Bruserud, Øystein.
The angioregulatory cytokine network in human acute myeloid leukemia - from leukemogenesis via remission induction to stem cell transplantation. European Cytokine Network 2012 ;Volum 23.(4) s. 140-153
HAUKELAND UiB Untitled
 
2011
30 Bruserud, Øystein; Hatfield, Kimberley Joanne; Reikvam, Håkon.
Heat shock protein 90 (HSP90) inhibition in acute myeloid leukemia-Targeting of disease heterogeneity through direct and indirect antileukemic effects. Leukemia Research 2011 ;Volum 35.(9) s. 1156-1158
HAUKELAND UiB Untitled
 
31 Ersvær, Elisabeth; Hatfield, Kimberley Joanne; Reikvam, Håkon; Bruserud, Øystein.
Future perspectives: therapeutic targeting of notch signalling may become a strategy in patients receiving stem cell transplantation for hematologic malignancies. Bone Marrow Research 2011 ;Volum 2011.(2011)
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32 Hatfield, Kimberley Joanne; Lassalle, Philippe; Leiva, Rafael Alexander Mo; Lindås, Roald; Wendelbo, Øystein; Bruserud, Øystein.
Serum levels of endothelium-derived endocan are increased in patients with untreated acute myeloid leukemia. Hematology 2011 ;Volum 16.(6) s. 351-356
HAUKELAND UiB Untitled
 
33 Reikvam, Håkon; Hatfield, Kimberley Joanne; Kittang, Astrid Marta Olsnes; Hovland, Randi; Bruserud, Øystein.
Acute myeloid leukemia with the t(8;21) translocation: clinical consequences and biological implications. Journal of Biomedicine and Biotechnology 2011 s. -
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2010
34 Bruserud, Øystein; Hatfield, Kimberley Joanne.
Antivascular combo therapy: up-and-coming. Blood 2010 ;Volum 116.(9) s. 1389-1390
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35 Hatfield, Kimberley Joanne; Bedringaas, Siv Lise; Gjertsen, Bjørn Tore; Bruserud, Øystein.
OXYGEN LEVELS INFLUENCE THE CYTOKINE RELEASE PROFILE OF AML CELLS. Experimental Hematology 2010 ;Volum 38.(9) s. S119-S119
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36 Hatfield, Kimberley Joanne; Bedringaas, Siv Lise; Ryningen, Anita; Gjertsen, Bjørn Tore; Bruserud, Øystein.
Hypoxia increases HIF-1 alpha expression and constitutive cytokine release by primary human acute myeloid leukaemia cells. European Cytokine Network 2010 ;Volum 21.(3) s. 154-164
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37 Hatfield, Kimberley Joanne; Reikvam, Håkon; Bruserud, Øystein.
The Crosstalk Between the Matrix Metalloprotease System and the Chemokine Network in Acute Myeloid Leukemia. Current Medicinal Chemistry 2010 ;Volum 17.(36) s. 4448-4461
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38 Kittang, Astrid Marta Olsnes; Hatfield, Kimberley Joanne; Sand, Kristoffer Evebø; Reikvam, Håkon; Bruserud, Øystein.
The Chemokine Network in Acute Myelogenous Leukemia: Molecular Mechanisms Involved in Leukemogenesis and Therapeutic Implications. Current Topics in Microbiology and Immunology 2010 ;Volum 341. s. 149-172
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39 Reikvam, Håkon; Hatfield, Kimberley Joanne; Ersvær, Elisabeth; Ryningen, Anita; Bruserud, Øystein.
PHARMACOLOGICAL TARGETING OF THE PI3K-AKT/PKB-MTOR PATHWAY ALTERS LOCAL ANGIOREGULATION IN ACUTE MYELOGENOUS LEUKEMIA. Haematologica 2010 ;Volum 95.(suppl 2) s. 266-266
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40 Reikvam, Håkon; Hatfield, Kimberley Joanne; Lassalle, Philippe; Kittang, Astrid Marta Olsnes; Ersvær, Elisabeth; Bruserud, Øystein.
Targeting the angiopoietin (Ang)/Tie-2 pathway in the crosstalk between acute myeloid leukaemia and endothelial cells: studies of Tie-2 blocking antibodies, exogenous Ang-2 and inhibition of constitutive agonistic Ang-1 release. Expert Opinion on Investigational Drugs 2010 ;Volum 19.(2) s. 169-183
HAUKELAND UiB Untitled
 
41 Reikvam, Håkon; Hatfield, Kimberley Joanne; Øyan, Anne Margrete; Kalland, Karl-Henning; Kittang, Astrid Marta Olsnes; Bruserud, Øystein.
Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation. European Journal of Haematology 2010 ;Volum 84.(3) s. 239-251
HAUKELAND UiB Untitled
 
2009
42 Hatfield, Kimberley Joanne.
Angiogenic factors in human acute myeloid leukaemia : studies of the crosstalk between endothelial and leukaemic cells. Universitetet i Bergen 2009 (ISBN 978-82-308-0770-5)
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43 Hatfield, Kimberley Joanne; Øyan, Anne Margrete; Ersvær, Elisabeth; Kalland, Karl-Henning; Lassalle, Philippe; Gjertsen, Bjørn Tore; Bruserud, Øystein.
Phase II study of subcutaneous alemtuzumab without dose escalation in patients with advanced-stage, relapsed chronic lymphocytic leukaemia. British Journal of Haematology 2009 ;Volum 144.(1) s. 53-68
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44 Hatfield, Kimberley Joanne; Øyan, Anne Margrete; Ersvær, Elisabeth; Kalland, Karl-Henning; Lassalle, Philippe; Gjertsen, Bjørn Tore; Bruserud, Øystein.
Primary human acute myeloid leukaemia cells increase the proliferation of microvascular endothelial cells through the release of soluble mediators. British Journal of Haematology 2009 ;Volum 144.(1) s. 53-68
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45 Olsnes, Astrid Marta; Hatfield, Kimberley Joanne; Bruserud, Øystein.
The chemokine system and its contribution to leukemogenesis and treatment responsiveness in patients with acute myeloid leukemia. Balkan Union of Oncology. Journal 2009 ;Volum 14. s. S131-S140
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46 Reikvam, Håkon; Hatfield, Kimberley Joanne; Olsnes, Astrid Marta; Øyan, Anne Margrete; Kalland, Karl-Henning; Bruserud, Øystein.
PRIMARY HUMAN ACUTE MYELOGENOUS LEUKEMIA CELLS SHOW CONSTITUTIVE RELEASE OF SEVERAL MATRIX METALLOPROTEASES AND THEIR INHIBITORS. Haematologica 2009 ;Volum 94. s. 545-545
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47 Reikvam, Håkon; Hatfield, Kimberley Joanne; Øyan, Anne Margrete; Kalland, Karl-Henning; Kittang, Astrid Marta Olsnes; Bruserud, Øystein.
Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors; release profile and pharmacological modulaion. European Journal of Haematology 2009 ;Volum 84. s. 239-251
HAUKELAND UiB Untitled
 
2008
48 Hatfield, Kimberley Joanne; Hovland, Randi; Øyan, Anne Margrete; Kalland, Karl-Henning; Ryningen, Anita; Gjertsen, Bjørn Tore; Bruserud, Øystein.
Release of angiopoietin-1 by primary human acute myelogenous leukemia cells is associated with mutations of nucleophosmin, increased by bone marrow stromal cells and possibly antagonized by high systemic angiopoietin-2 levels. Leukemia 2008 ;Volum 22.(2) s. 287-293
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2007
49 Ersvær, Elisabeth; Hampson, Peter; Hatfield, Kimberley Joanne; Ulvestad, Elling; Wendelbo, Øystein; Lord, Janet M.; Gjertsen, Bjørn Tore; Bruserud, Øystein.
T cells remaining after intensive chemotherapy for acute myelogenous leukemia show a broad cytokine release profile including high levels of interferon-gamma that can be further increased by a novel protein kinase C agonist PEP005. Cancer Immunology and Immunotherapy 2007 ;Volum 56.(6) s. 013-925
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50 Hatfield, Kimberley Joanne; Hovland, Randi; Øyan, Anne Margrete; Kalland, Karl-Henning; Bruserud, Øystein.
Release of angiopoietin-1 by acute myelogenous leukemia (AML) cells is increased by stromal cells and associated with mutations in the nucleophosmin (NPM) gene. Experimental Hematology 2007 ;Volum 35.(9) Suppl. 2 s. 72-72
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