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1 Amrutkar, Manoj; Larsen, Emma Kristine; Aasrum, Monica; Finstadsveen, Anette Vefferstad; Andresen, Per Arne; Verbeke, Caroline Sophie; Gladhaug, Ivar Prydz.
Establishment and Characterization of Paired Primary Cultures of Human Pancreatic Cancer Cells and Stellate Cells Derived from the Same Tumor. Cells 2020 ;Volum 9.(1)
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2 Amrutkar, Manoj; Aasrum, Monica; Verbeke, Caroline Sophie; Gladhaug, Ivar Prydz.
Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells. BMC Cancer 2019 ;Volum 19.(596) s. -
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3 Cansby, Emmelie; Kulkarni, Nagaraj M; Magnusson, Elin; Kurhe, Yeshwant; Amrutkar, Manoj; Nerstedt, Annika; Ståhlman, Marcus; Sihlbom, Carina; Marschall, Hanns-Ulrich; Borén, Jan; Blüher, Matthias; Mahlapuu, Margit.
Protein Kinase MST3 Modulates Lipid Homeostasis in Hepatocytes and Correlates With Nonalcoholic Steatohepatitis in Humans. The FASEB Journal 2019 ;Volum 33.(9) s. 9974-9989
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4 Cansby, Emmelie; Nunez-duran, Esther; Magnusson, Elin; Amrutkar, Manoj; Booten, Sheri L.; Kulkarni, Nagaraj M; Svensson, L. Thomas; Borén, Jan; Marschall, Hanns-Ulrich; Aghajan, Mariam; Mahlapuu, Margit.
Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease. Cellular and Molecular Gastroenterology and Hepatology (CMGH) 2019 ;Volum 7.(3) s. 597-618
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5 Lenggenhager, Daniela; Amrutkar, Manoj; Santha, Petra; Aasrum, Monica; Löhr, Johannes-Matthias; Gladhaug, Ivar Prydz; Verbeke, Caroline Sophie.
Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions With Pancreatic Cancer Cells. Cells 2019 ;Volum 8:E23.(1) s. 1-18
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6 Cansby, Emmelie; Magnusson, Elin; Nunez-duran, Esther; Amrutkar, Manoj; Pedrelli, Matteo; Parini, Paolo; Hoffmann, Jenny; Ståhlman, Marcus; Howell, Brian w.; Marschall, Hanns-Ulrich; Borén, Jan; Mahlapuu, Margit.
STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of Hypercholesterolemia. Arteriosclerosis, Thrombosis and Vascular Biology 2018 ;Volum 38.(8)
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7 Sutt, Silva; Cansby, Emmelie; Paul, Alexandra; Amrutkar, Manoj; Nunez-duran, Esther; Kulkarni, Nagaraj M; Ståhlman, Marcus; Boren, Jan; Laurencikiene, Jurga; Howell, Brian w.; Enerbäck, Sven; Mahlapuu, Margit.
STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue. Journal of Endocrinology 2018 ;Volum 238.(3) s. 187-202
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8 Amrutkar, Manoj; Gladhaug, Ivar Prydz.
Pancreatic cancer chemoresistance to gemcitabine. Cancers 2017 ;Volum 9.(11:157) s. 1-23
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9 Chursa, Urszula; Nunez-duran, Esther; Cansby, Emmelie; Amrutkar, Manoj; Sutt, Silva; Ståhlman, Marcus; Olsson, Britt-marie; Borén, Jan; Johansson, Maria e.; Bäckhed, Fredrik; Johansson, Bengt r.; Sihlbom, Carina; Mahlapuu, Margit.
Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle. Diabetologia 2017 ;Volum 60.(3) s. 553-567
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10 Nunez-duran, Esther; Aghajan, Mariam; Amrutkar, Manoj; Sutt, Silva; Cansby, Emmelie; Booten, Sheri l.; Watt, Andrew; Ståhlman, Marcus; Stefan, Norbert; Haring, Hans-ulrich; Staiger, Harald; Borén, Jan; Marschall, Hanns-Ulrich; Mahlapuu, Margit.
Serine/Threonine Protein Kinase 25 Antisense Oligonucleotide Treatment Reverses Glucose Intolerance, Insulin Resistance, and Nonalcoholic Fatty Liver Disease in Mice. Hepatology communications. 2017 ;Volum 2.(1) s. 69-83
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11 Amrutkar, Manoj; Chursa, Urszula; Kern, Matthias; Nunez-duran, Esther; Ståhlman, Marcus; Sutt, Silva; Borén, Jan; Johansson, Bengt r.; Marschall, Hanns-Ulrich; Blüher, Matthias; Mahlapuu, Margit.
STK25 is a critical determinant in nonalcoholic steatohepatitis. The FASEB Journal 2016 ;Volum 30.(10) s. 3628-3643
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12 Amrutkar, Manoj; Kern, Matthias; Nunez-duran, Esther; Ståhlman, Marcus; Cansby, Emmelie; Chursa, Urszula; Stenfeldt, Elin; Borén, Jan; Blüher, Matthias; Mahlapuu, Margit.
Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in humans. Diabetologia 2016 ;Volum 59. s. 341-353
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13 Amrutkar, Manoj; Cansby, Emmelie; Chursa, Urszula; Nunez-duran, Esther; Chanclón, Belén; Ståhlman, Marcus; Friden, Vincent; Mannerås-holm, Louise; Wickman, Anna; Smith, Ulf; Bäckhed, Fredrik; Borén, Jan; Howell, Brian w.; Mahlapuu, Margit.
Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model. Diabetes 2015 ;Volum 64. s. 2791-2804
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14 Amrutkar, Manoj; Cansby, Emmelie; Nunez-duran, Esther; Pirazzi, Carlo; Ståhlman, Marcus; Stenfeldt, Elin; Smith, Ulf; Borén, Jan; Mahlapuu, Margit.
Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH. The FASEB Journal 2015 ;Volum 29.(4) s. 1564-1576
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15 Cansby, Emmelie; Nerstedt, Annika; Amrutkar, Manoj; Nunez-duran, Esther; Smith, Ulf; Mahlapuu, Margit.
Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is maintained. Molecular and Cellular Endocrinology 2014 ;Volum 393. s. 143-151
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16 Cansby, Emmelie; Amrutkar, Manoj; Mannerås-holm, Louise; Nerstedt, Annika; Reyahi, Azadeh; Stenfeldt, Elin; Booten, Sheri l.; Carlsson, Peter; Smith, Ulf; Zierath, Juleen r.; Mahlapuu, Margit.
Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet. The FASEB Journal 2013 ;Volum 27.(9) s. 3660-3671
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17 Nerstedt, Annika; Cansby, Emmelie; Amrutkar, Manoj; Smith, Ulf; Mahlapuu, Margit.
Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes. Molecular and Cellular Endocrinology 2013 ;Volum 375. s. 68-78
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