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2019
1 Arnesen, Liv Henriette; Haj Yasein, Nadia; Tungen, Jørn Eivind; Södling, Helen; Matthews, Jason; Paulsen, Steinar M; Nebb, Hilde Irene; Sylte, Ingebrigt; Hansen, Trond Vidar; Sæther, Thomas.
Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist. Bioorganic & Medicinal Chemistry 2019 ;Volum 27.(18) s. 4059-4068
UiO UiT Untitled
 
2 Evenseth, Linn; Kristiansen, kurt; Song, You; Tollefsen, Knut-Erik; Sylte, Ingebrigt.
In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding. Computational Toxicology 2019 ;Volum 12:100091. s. 1-11
NIVA UiT Untitled
 
3 Evenseth, Linn; Warszycki, Dawid; Bojarski, Andrzej J; Gabrielsen, Mari; Sylte, Ingebrigt.
In Silico Methods for the Discovery of Orthosteric GABAB Receptor Compounds. Molecules 2019 ;Volum 24.(5) s. 1-20
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4 Ezawa, Takuya; Sugiyama, Satoshi; Ara, Ayami; Sylte, Ingebrigt; Kurita, Noriyuki.
Design of galardine analogs as putative psudolysin inhibitors based on ab initio fragment molecular orbital calculations. Journal of Biomolecular Structure and Dynamics 2019
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5 Fjelldal, Marthe Fredheim; Freyd, Thibaud; Evenseth, Linn; Sylte, Ingebrigt; Ring, Avi; Paulsen, Ragnhild Elisabeth.
Exploring the overlapping binding sites of ifenprodil and EVT‐101 in GluN2B‐containing NMDA receptors using novel chicken embryo forebrain cultures and molecular modeling. Pharmacology Research & Perspectives 2019 ;Volum 7.(3) s. 1-15
FFI UiO UiT Untitled
 
6 Tollefsen, Knut-Erik; Cronin, Marc Timothy David; Evenseth, Linn; Firman, James W.; Iguchi, Taisen; Lalone, Carlie; Mellor, Claire; Sylte, Ingebrigt; Toyota, K.; Villeneuve, Daniel L.; Song, You.
). Endocrine Disruption in crustaceans – a “new” environmental challenge?. 20th Pollutant Responses in Marine Organism (PRIMO20) conference; 2019-05-19 - 2019-05-22
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2018
7 Al-Kazaale, Nora; Tran, Phuong Dan Dinh; Haidari, Farhad; Solum, Eirik Johansson; Liekens, Sandra; Vervaeke, Peter; Sylte, Ingebrigt; Cheng, Jing-Jy; Vik, Anders; Hansen, Trond Vidar.
Synthesis, molecular modeling and biological evaluation of potent analogs of 2-methoxyestradiol. Steroids 2018 ;Volum 136. s. 47-55
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8 Doering, Jon A.; Lee, Sehan; Kristiansen, kurt; Evenseth, Linn; Sylte, Ingebrigt; Barron, Mace G.; Lalone, Carlie.
In silico site-directed mutagenesis informs species-specific predictions of chemical susceptibility derived from the Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool. Toxicological Sciences 2018 ;Volum 166.(1) s. 131-145
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9 Hill, Katie L.; Mortensen, Åse-Karen; Teclechiel, Daniel; Willmore, William G.; Sylte, Ingebrigt; Jenssen, Bjørn Munro; Letcher, Robert James.
In Vitro and in Silico Competitive Binding of Brominated Polyphenyl Ether Contaminants with Human and Gull Thyroid Hormone Transport Proteins. Environmental Science and Technology 2018 ;Volum 52.(3) s. 1533-1541
NTNU UiT Untitled
 
10 Sylte, Ingebrigt; Dawadi, Rangita; Malla, Nabin; von Hofsten, Susannah; Nguyen, Tra-Mi; Solli, Ann Iren; Berg, Eli; Adekoya, Olayiwola; Svineng, Gunbjørg; Winberg, Jan-Olof.
The selectivity of galardin and an azasugar-based hydroxamate compound for human Matrix metalloproteases and bacterial metalloproteases. PLOS ONE 2018 ;Volum 13.(8) s. -
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11 Tollefsen, Knut Erik; Cronin, Marc Timothy David; Evensen, Øystein; Evenseth, Linn; Falciani, Francesco; Iguchi, Taisen; Lalone, Carlie; Li, Yang; Mellor, Claire; Perkins, Edward J.; Rundberget, Thomas; Salbu, Brit; Sylte, Ingebrigt; Villeneuve, Daniel L.; Vinas, N.; Song, You.
AOP-informed assessment of Endocrine Disruption in freshwater crustaceans. 28th annual SETAC Europe Meeting; 2018-05-13 - 2018-05-17
NIVA UiT NMBU Untitled
 
12 Tollefsen, Knut Erik; Cronin, Marc Timothy David; Evenseth, Linn; Firman, James W.; Iguchi, Taisen; Lalone, Carlie; Mellor, Claire; Sylte, Ingebrigt; Toyota, K.; Villeneuve, Daniel L.; Song, You.
AOP-informed chemical screening, prioritization and risk assessment of arthropod Endocrine Disruptors. SETAC workshop on Hight-Throughput Screening; 2018-04-16 - 2018-04-18
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2017
13 Ara, Ayami; Kadoya, Ryushi; Ishimura, Hiromi; Shimamura, Kanako; Sylte, Ingebrigt; Kurita, Noriyuki.
Specific interactions between zinc metalloproteinase and its inhibitors: Ab initio fragment molecular orbital calculations. Journal of Molecular Graphics and Modelling 2017 ;Volum 75. s. 277-286
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14 Chilmonczyk, Zdzislaw; Bojarski, Andrzej J.; Pilc, Andrzej; Sylte, Ingebrigt.
Serotonin transporter and receptor ligands with antidepressant activity as neuroprotective and proapoptotic agents. Pharmacological Reports 2017 ;Volum 69.(3) s. 469-478
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15 Freyd, Thibaud; Warszycki, Dawid; Mordalski, Stefan; Bojarski, Andrzej J; Sylte, Ingebrigt; Gabrielsen, Mari.
Ligand-guided homology modelling of the GABA&lt;sub&gt;B2&lt;/sub&gt; subunit of the GABA&lt;sub&gt;B&lt;/sub&gt; receptor. PLOS ONE 2017 ;Volum 12.(3)
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16 Song, You; Villeneuve, Daniel L.; Iguchi, Taisen; Rodriguez-Sanchez, Neus; Rundberget, Thomas; Mellor, Claire; Cronin, Marc Timothy David; Evenseth, Linn; Sylte, Ingebrigt; Lalone, Carlie; Høgåsen, Tore; Falciani, Francesco; Garcia-Reyero, Natalia; Perkins, Edward J.; Evensen, Øystein; Xie, Li; Lyne, Fern; Gomes, Tania; Lillicrap, Adam David; Salbu, Brit; Tollefsen, Knut Erik.
Development of invertebrate Adverse Outcome Pathways (AOPs) for mechanistically-based risk assessment. China’s 4th Symposium on Ecotoxicology; 2017-04-24
NIVA UiT NMBU Untitled
 
17 Song, You; Villeneuve, Daniel L.; Iguchi, Taisen; Rundberget, Thomas; Mellor, Claire; Cronin, Marc Timothy David; Evenseth, Linn; Sylte, Ingebrigt; Lalone, Carlie; Hackermüller, Jörg; Høgåsen, Tore; Falciani, Francesco; Garcia-Reyero, Natalia; Perkins, Edward J.; Evensen, Øystein; Xie, Li; Lyne, Fern; Gomes, Tania; Lillicrap, Adam David; Salbu, Brit; Tollefsen, Knut Erik.
Development of invertebrate Adverse Outcome Pathways (AOPs) for mechanistically-based risk assessment. International Symposium on Chemicals Risk Prediction and Management (ISCRPM-2017); 2017-04-25
NIVA UiT NMBU Untitled
 
18 Song, You; Villeneuve, Daniel L.; Iguchi, Taisen; Rundberget, Thomas; Mellor, Claire; Cronin, Marc Timothy David; Evenseth, Linn; Sylte, Ingebrigt; Lalone, Carlie; Høgåsen, Tore; Falciani, Francesco; Garcia-Reyero, Natalia; Perkins, Edward J.; Evensen, Øystein; Xie, Li; Lyne, Fern; Gomes, Tania; Lillicrap, Adam David; Salbu, Brit; Tollefsen, Knut Erik.
Development of invertebrate Adverse Outcome Pathways (AOPs) for mechanistically-based risk assessment. Nanjing Univeristy internal seminar; 2017-04-23
NIVA UiT NMBU Untitled
 
19 Viktorsson, Elvar Örn; Gabrielsen, Mari; Kumarachandran, Nugalya; Sylte, Ingebrigt; Rongved, Pål; Åstrand, Ove Alexander Høgmoen; Kase, Eili Tranheim.
Regulation of liver X receptor target genes by 22-functionalized oxysterols. Synthesis, in silico and in vitro evaluations. Steroids 2017 ;Volum 118. s. 119-127
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20 Warszycki, Dawid; Rueda, Manuel; Mordalski, Stefan; Kristiansen, kurt; Satala, Grzegorz; Rataj, Krzysztof; Chilmonczyk, Zdzislaw; Sylte, Ingebrigt; Abagyan, Ruben; Bojarski, Andrzej J.
From Homology Models to a Set of Predictive Binding Pockets-a 5-HT&lt;sub&gt;1A&lt;/sub&gt; Receptor Case Study. Journal of chemical information and computer sciences 2017 ;Volum 57.(2) s. 311-321
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21 Åstrand, Ove Alexander Høgmoen; Viktorsson, Elvar Örn; Kristensen, Aleksander Lim; Ekeberg, Dag; Røberg-Larsen, Hanne; Wilson, Steven Ray Haakon; Gabrielsen, Mari; Sylte, Ingebrigt; Rustan, Arild; Thoresen, G. Hege; Rongved, Pål; Kase, Eili Tranheim.
Synthesis, in vitro and in vivo biological evaluation of new oxysterols as modulators of the liver X receptors. Journal of Steroid Biochemistry and Molecular Biology 2017 ;Volum 165. s. 323-330
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2016
22 Routti, Heli Anna Irmeli; Lille-Langøy, Roger; Berg, Mari Katrine; Fink, Trine; Harju, Mikael; Kristiansen, Kurt; Rostkowski, Pawel Marian; Rusten, Marte; Sylte, Ingebrigt; Øygarden, Lene Eidsvik; Goksøyr, Anders.
Environmental chemicals modulate polar bear (Ursus maritimus) Peroxisome Proliferator-Activated Receptor Gamma (PPARG) and adipogenesis in vitro. Environmental Science and Technology 2016 ;Volum 50.(19) s. 10708-10720
NILU NPI UiB UiT Untitled
 
23 Sjøli, Stian; Nuti, Elisa; Camodeca, Caterina; Bilto, Irina; Rossello, Armando; Winberg, Jan-Olof; Sylte, Ingebrigt; Adekoya, Olayiwola.
Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors. European Journal of Medicinal Chemistry 2016 ;Volum 108. s. 141-153
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24 Sæther, Thomas; Moldes-Anaya, Angel; Tungen, Jørn Eivind; Vik, Anders; Paulsen, Steinar M; Sylte, Ingebrigt; Hansen, Trond Vidar; Nebb, Hilde Irene.
Anti-diabetic activity from marine lipids: new anti-diabetic drugs. Throne Holst Symposium; 2016-05-19 - 2016-05-19
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2015
25 Chilmonczyk, Zdzislaw; Bojarski, Andrzej Jacek; Pilc, Andrzej; Sylte, Ingebrigt.
Functional selectivity and antidepressant activity of serotonin 1A receptor ligands. International Journal of Molecular Sciences 2015 ;Volum 16.(8) s. 18474-18506
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26 Kaupang, Åsmund; Paulsen, Steinar Martin; Steindal, Calin Constantin; Ravna, Aina Westrheim; Sylte, Ingebrigt; Halvorsen, Trine Grønhaug; Thoresen, G. Hege; Hansen, Trond Vidar.
Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618. European Journal of Medicinal Chemistry 2015 ;Volum 94. s. 229-236
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27 Mortensen, Åse-Karen.
Competitive binding of persistent organic pollutants to the thyroid hormone transport protein transthyretin in Glaucous gull (Larus hypoerboreus). Trondheim, Norway: Department of Biology, Norwegian University of Science and Technology 2015
NILU NTNU UiT UNIS Untitled
 
28 Odunuga, Odutayo O.; Adekoya, Olayiwola; Sylte, Ingebrigt.
High-level expression of pseudolysin, the extracellular elastase of Pseudomonas aeruginosa, in Escherichia coli and its purification. Protein Expression and Purification 2015 ;Volum 113. s. 79-84
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29 Solum, Eirik Johansson; Cheng, Jing-Jy; Sylte, Ingebrigt; Vik, Anders; Hansen, Trond Vidar.
Synthesis, biological evaluation and molecular modeling of new analogs of the anti-cancer agent 2-methoxyestradiol: potent inhibitors of angiogenesis. RSC Advances 2015 ;Volum 5.(41) s. 32497-32504
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30 Sæther, Thomas; Moldes-Anaya, Angel; Tungen, Jørn Eivind; Vik, Anders; Paulsen, Steinar Martin; Sylte, Ingebrigt; Hansen, Trond Vidar; Nebb, Hilde Irene.
Anti-diabetic activity from marine lipids: new anti-diabetic drugs. EMBO Conference on Nuclear Receptors; 2015-09-24 - 2015-09-28
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31 Wushur, Imin; Sylte, Ingebrigt; Winberg, Jan-Olof.
The catalytic reaction mechanism of drosophilid alcohol dehydrogenases. Perspectives in Science 2015 ;Volum 4. s. 46-56
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2014
32 Adekoya, Olayiwola; Sjøli, Stian; Wushur, Imin; Bilto, Irina; Marques, Sergio M; Santos, M Amelia; Nuti, Elisa; Cercignani, Giovanni; Rossello, Armando; Winberg, Jan-Olof; Sylte, Ingebrigt.
Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors. European Journal of Medicinal Chemistry 2014 ;Volum 89. s. 340-348
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33 Chilmonczyk, Zdzislaw; Bojarski, Andrzej J.; Sylte, Ingebrigt.
Ligand-directed traffickingof receptor stimulus. Pharmacological Reports 2014 ;Volum 66.(6) s. 1011-1021
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34 Gabrielsen, Mari; Kurczab, Rafal; Siwek, Agata; Wolak, Malgorzata; Ravna, Aina Westrheim; Kristiansen, kurt; Kufareva, Irina; Abagyan, Ruben; Nowak, Gabriel; Chilmonczyk, Zdzislaw; Sylte, Ingebrigt; Bojarski, Andrzej J..
Identification of novel serotonin transporter compounds by virtual Screening. Journal of Chemical Information and Modeling 2014 ;Volum 54.(3) s. 933-943
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35 Jantan, Ibrahim; Bukhari, Syed Nasir Abbas; Adekoya, Olayiwola; Sylte, Ingebrigt.
Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A&lt;sub&gt;2&lt;/sub&gt;, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines. Drug Design, Development and Therapy 2014 ;Volum 8. s. 1405-1418
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36 Kufareva, Irina; Katritch, Vsevolod; Freyd, Thibaud; Gabrielsen, Mari; Kristiansen, kurt; Sylte, Ingebrigt; Stevens, Raymond C.; Abagyan, Ruben.
Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: Meeting new challenges. Structure 2014 ;Volum 22.(8) s. 1120-1139
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37 Lindin, inger; Wuxiuer, Yimingjiang; Ravna, Aina Westrheim; Moens, Ugo; Sylte, Ingebrigt.
Comparative molecular dynamics simulations of mitogen-activated protein kinase-activated protein kinase 5. International Journal of Molecular Sciences 2014 ;Volum 15.(3) s. 4878-4902
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38 Sjøli, Stian; Solli, Ann Iren; Akselsen, Øyvind Wilhelm; Jiang, Yang; Berg, Eli; Hansen, Trond Vidar; Sylte, Ingebrigt; Winberg, Jan-Olof.
PAC-1 and isatin derivatives are weak matrix metalloproteinase inhibitors. Biochimica et Biophysica Acta 2014 ;Volum 10.(1840) s. 3162-3169
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39 Song, You; Antczak, Philipp; Cronin, Mark T.; Evenseth, Linn; Evensen, Øystein; Falciani, Francesco; Høgåsen, Tore; Iguchi, Taisen; Lalone, Carlie; Mellor, Claire; Perkins, Edward; Salbu, Brit; Sylte, Ingebrigt; Garcia-Reyero, Natalia; Villeneuve, Daniel; Tollefsen, Knut Erik.
Development of adverse outcome pathways for endocrine disruption in Daphnia magna. SETAC North America Annual Meeting; 2014-11-09 - 2014-11-13
NIVA UiT NMBU Untitled
 
40 Song, You; Cronin, Mark T.; Evensen, Øystein; Falciani, Francesco; Garcia-Reyero, Natalia; Høgåsen, Tore; Iguchi, Taisen; Langford, Katherine; Lalone, Carlie; Lillicrap, Adam David; Mellor, Claire; Perkins, Edward; Petersen, Karina; Salbu, Brit; Sylte, Ingebrigt; Thomas, Kevin V; Tollefsen, Knut Erik.
EDRISK: Development of adverse outcome pathways for endocrine disruption in Daphnia magna. Scientific seminar at The Norwegian Environmental agency; 2014-03-11 - 2014-03-11
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41 Song, You; Cronin, Mark T.; Evensen, Øystein; Falciani, Francesco; Høgåsen, Tore; Iguchi, Taisen; Lalone, Carlie; Lillicrap, Adam David; Petersen, Karina; Perkins, Edward; Rundberget, Thomas; Salbu, Brit; Sylte, Ingebrigt; Thomas, Kevin V; Garcia-Reyero, Natalia; Tollefsen, Knut Erik.
Development of adverse outcome pathways for endocrine disruption in Daphnia magna. SETAC Europe 24th annual meeting; 2014-05-11 - 2014-05-15
NIVA UiT NMBU Untitled
 
42 Wushur, Imin; Winberg, Jan-Olof; Sylte, Ingebrigt.
Comparative molecular dynamic simulations of wild type and Thr114Val mutated Scaptodrosophila lebanonensis alcohol dehydrogenase. Journal of Biomolecular Structure and Dynamics 2014 ;Volum 32.(3) s. 465-476
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43 Åstrand, Ove Alexander Høgmoen; Gikling, Ingveig; Sylte, Ingebrigt; Rustan, Arild; Thoresen, G. Hege; Rongved, Pål; Kase, Eili Tranheim.
Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models. European Journal of Medicinal Chemistry 2014 ;Volum 74. s. 258-263
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44 Åstrand, Ove Alexander Høgmoen; Sandberg, Marcel; Sylte, Ingebrigt; Gorbitz, Carl Henrik; Thoresen, G. Hege; Kase, Eili Tranheim; Rongved, Pål.
Synthesis and initial biological evaluation of new mimics of the LXR-modulator 22(S)-hydroxycholesterol. Bioorganic & Medicinal Chemistry 2014 ;Volum 22.(1) s. 643-650
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2013
45 Baglo, Yan; Gabrielsen, Mari; Sylte, Ingebrigt; Gederaas, Odrun Arna.
Homology Modeling of Human <gamma>-Butyric Acid Transporters and the Binding of Pro-drugs 5-Aminolevulinic Acid and Methyl Aminolevulinic Acid used in Photodynamic Therapy. 15th Congress of the European Society for Photobiology; 2013-09-02 - 2013-09-06
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46 Baglo, Yan; Gabrielsen, Mari; Sylte, Ingebrigt; Gederaas, Odrun Arna.
Homology Modeling of Human <gamma>-Butyric Acid Transporters and the Binding of Pro-drugs 5-Aminolevulinic Acid and Methyl Aminolevulinic Acid used in Photodynamic Therapy. PLOS ONE 2013 ;Volum 8.(6)
NTNU UiT Untitled
 
47 Gabrielsen, Mari; Wolosewicz, Karol; Zawadzka, Anna; Kossakowski, Jerzy; Nowak, Gabriel; Wolak, Malgorzata; Stachowicz, Katarzyna; Siwek, Agata; Ravna, Aina Westrheim; Kufareva, Irina; Kozerski, Lech; Bednarek, Elzbieta; Sitkowski, Jerzy; Bocian, Wojciech; Abagyan, Ruben; Bojarski, Andrezej J; Sylte, Ingebrigt; Chilmonczyk, Zdzislaw.
Synthesis, Antidepressant Evaluation and Docking Studies of Long-Chain Alkylnitroquipazines as Serotonin Transporter Inhibitors. Chemical Biology and Drug Design 2013 ;Volum 81.(6) s. 695-706
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48 Larsen, Anett Kristin; Kristiansen, kurt; Sylte, Ingebrigt; Seternes, Ole Morten; Bang, Berit.
Differences in PAR-2 activating potential by king crab (Paralithodes camtschaticus), salmon (Salmo salar), and bovine (Bos taurus) trypsin. BMC Research Notes 2013 ;Volum 6. s. 281-
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49 Lindin, inger; Wuxiuer, Yimingjiang; Kufareva, Irina; Abagyan, Ruben; Moens, Ugo; Sylte, Ingebrigt; Ravna, Aina Westrheim.
Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5). Theoretical Biology Medical Modelling 2013 ;Volum 10. s. -
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50 Ravna, Aina Westrheim; Sylte, Ingebrigt.
Drug design på data'n. Ottar 2013 (297) s. 22-26
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