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2021
1 Frøhlich, Christopher; Gama, João Alves; Harms, Klaus; Hirvonen, Viivi H. A.; Lund, Bjarte Aarmo; van der Kamp, Marc W.; Johnsen, Pål Jarle; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S..
Cryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations. mSphere 2021
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2 Lund, Bjarte Aarmo; Thomassen, Ane Molden; Carlsen, Trine Josefine Warg; Leiros, Hanna-Kirsti Schrøder.
Biochemical and biophysical characterization of the OXA-48-like carbapenemase OXA-436. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2021 ;Volum 77.(9) s. 312-318
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3 Pan, Jolyn; Lian, Kjersti; Sarre, Aili; Leiros, Hanna-Kirsti Schrøder; Williamson, Adele Kim.
Bacteriophage origin of some minimal ATP-dependent DNA ligases: a new structure from Burkholderia pseudomallei with striking similarity to Chlorella virus ligase. Scientific Reports 2021 ;Volum 11. s. 1-14
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4 Silk, Mitchell; Price, Jason R.; Mohanty, Biswaranjan; Leiros, Hanna-Kirsti Schrøder; Lund, Bjarte Aarmo; Thompson, Phillip E.; Chalmers, David.
Side-Chain Interactions in d/l Peptide Nanotubes: Studies by Crystallography, NMR Spectroscopy and Molecular Dynamics. Chemistry - A European Journal 2021
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2020
5 Frøhlich, Christopher; Leiros, Hanna-Kirsti S.; Miton, Charlotte; Tokuriki, Nobuhiko.
Ceftazidime drives the evolution of the carbapenemase OXA-48. GW4 Multidisciplinary Approaches to AMR: From Bench to Bedside and Beyond 2020; 2020-12-01 - 2020-12-03
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6 Frøhlich, Christopher; Sørum, Vidar; Huber, Sandra; Samuelsen, Ørjan; Berglund, Fanny; Kristiansson, Erik; Kotsakis, Stathis D.; Marathe, Nachiket; Larsson, DG Joakim; Leiros, Hanna-Kirsti Schrøder.
Structural and biochemical characterization of the environmental MBLs MYO-1, ECV-1 and SHD-1. Journal of Antimicrobial Chemotherapy 2020 ;Volum 75. s. 2554-2563
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7 Leiros, Hanna-Kirsti S..
På Labben med Forskningsdagene 2020. På Institutt for kjemi, UiT. "Proteiner som gjør at bakterier er resistente mot antibiotika".. YouTube [Internett] 2020-09-27
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8 Leiros, Hanna-Kirsti S..
Vil ha 40 prosent kvinner i toppstillingar. http://kifinfo.no [Fagblad] 2020-09-24
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9 Leiros, Hanna-Kirsti S.; Thomassen, Ane Molden; Samuelsen, Ørjan; Flach, Carl-Fredrik; Kotsakis, Stathis D.; Larsson, Joakim.
Structural insights into the enhanced carbapenemase efficiency of OXA-655 compared to OXA-10. FEBS Open Bio 2020 ;Volum 10.(9) s. 1821-1832
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10 Muhammad, Zeeshan; Skagseth, Susann; Boomgaren, Marc; Akhter, Sundus; Frøhlich, Christopher; Ismael, Aya; Christopeit, Tony; Bayer, Annette; Leiros, Hanna-Kirsti S..
Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-β-lactamases. Bioorganic & Medicinal Chemistry 2020 ;Volum 28.(15) s. -
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11 Samuelsen, Ørjan; Åstrand, Ove Alexander Høgmoen; Frøhlich, Christopher; Heikal, Adam; Skagseth, Susann; Carlsen, Trine Josefine Olsen; Leiros, Hanna-Kirsti S.; Bayer, Annette; Schnaars, Christian; Kildahl-Andersen, Geir; Lauksund, Silje; Finke, Sarah; Huber, Sandra; Gjøen, Tor; Andresen, Adriana Magalhaes Santos; Økstad, Ole Andreas; Rongved, Pål.
ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo. Antimicrobial Agents and Chemotherapy 2020 ;Volum 64.(6) s. -
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12 Steien, Tore Rasmussen; Leiros, Hanna-Kirsti S..
Kjemikerne prøver å stoppe kjeften på antibiotikadreperne. Norsk Farmaceutisk Tidsskrift 2020
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13 Williamson, Adele Kim; Leiros, Hanna-Kirsti S..
Structural insight into DNA joining: from conserved mechanisms to diverse scaffolds. Nucleic Acids Research (NAR) 2020 ;Volum 48.(15) s. 8225-8242
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2019
14 Frøhlich, Christopher; Leiros, Hanna-Kirsti S.; Johnsen, Pål Jarle; Samuelsen, Ørjan.
Sub-inhibitory concentrations of ceftazidime drive evolution of the OXA-48 carbapenemase. ECCMID 2019; 2019-04-13 - 2019-04-16
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15 Frøhlich, Christopher; Sørum, Vidar; Thomassen, Ane Molden; Johnsen, Pål Jarle; Leiros, Hanna-Kirsti S.; Samuelsen, Ørjan.
OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs. mSphere 2019 ;Volum 4.(2)
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16 Leiros, Hanna-Kirsti S..
Antibiotika resistens er et globalt problem. Nye inhibitorer og velkjente antibiotika, kan de sammen bli ny behandlings metode?. NT-Fak administrasjonen; 2019-03-19 - 2019-03-19
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17 Leiros, Hanna-Kirsti S..
Fighting the antibiotic resistant serine-beta-lactamase OXA-48 - through altered ceftazidime activity or new inhibitors?. Gjesteforelesning ved Biomedical Sciences, University of Bristol; 2019-12-04 - 2019-12-04
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18 Leiros, Hanna-Kirsti S..
Inhibitor potential of Serine- and Metallo-beta-lactamase inhibitors, and Biochemical and Biophysical characterization. AROHP 2019 workshop on Antimicrobial resistance (AMR), March 2019; 2019-03-05 - 2019-03-11
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19 Prandina, Anthony; Radix, Sylvie; Le Borgne, Marc; Jordheim, Lars Petter; Bousfiha, Zineb; Fröhlich, Christopher; Leiros, Hanna-Kirsti S.; Samuelsen, Ørjan; Frøvold, Espen; Rongved, Pål; Åstrand, Ove Alexander Høgmoen.
Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors. Tetrahedron 2019 ;Volum 75.(11) s. 1525-1540
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20 Williamson, Adele Kim; Leiros, Hanna-Kirsti S..
Structural intermediates of a DNA-ligase complex illuminate the role of the catalytic metal ion and mechanism of phosphodiester bond formation. Nucleic Acids Research (NAR) 2019 ;Volum 47.(14) s. 7147-7162
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2018
21 Ahkter, Sundus; Lund, Bjarte Aarmo; Ismael, Aya; Langer, Manuel; Isaksson, Johan; Christopeit, Tony; Leiros, Hanna-Kirsti S.; Bayer, Annette.
A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design. European Journal of Medicinal Chemistry 2018 ;Volum 145. s. 634-648
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22 Frøhlich, Christopher; Sørum, Vidar; Leiros, Hanna-Kirsti S.; Johnsen, Pål Jarle; Samuelsen, Ørjan.
Development of OXA-48 mediated ceftazidme-avibactam resistance is associated with an evolutionary trade-off. ECCMID; 2018-04-24
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23 Lund, Bjarte Aarmo; Thomassen, Ane Molden; Nesheim, Birgit Helene Berg; Carlsen, Trine Josefine Olsen; Isaksson, Johan; Christopeit, Tony; Leiros, Hanna-Kirsti S..
The biological assembly of OXA‐48 reveals a dimer interface with high charge complementarity and very high affinity. The FEBS Journal 2018 ;Volum 285.(22) s. 4214-4228
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24 Marcoccia, Francesca; Leiros, Hanna-Kirsti S.; Aschi, Massimiliano; Amicosante, Gianfranco; Perilli, Mariagrazia.
Exploring the role of L209 residue in the active site of NDM-1 a metallo-β-lactamase. PLOS ONE 2018 ;Volum 13.(1) s. -
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25 Samuelsen, Ørjan; Hansen, Frank; Aasnæs, Bettina; Hasman, Henrik; Lund, Bjarte Aarmo; Leiros, Hanna-Kirsti S.; Lilje, Berit; James Peter, Jessin Janice; Jakobsen, Lotte; Littauer, Pia; Søes, Lillian M; Holzknecht, Barbara J.; Andersen, Leif P; Stegger, Marc; Andersen, Paal S.; Hammerum, Anette M..
Dissemination and Characteristics of a Novel Plasmid-Encoded Carbapenem-Hydrolyzing Class D β-Lactamase, OXA-436, Found in Isolates from Four Patients at Six Different Hospitals in Denmark. Antimicrobial Agents and Chemotherapy 2018 ;Volum 62.(1)
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26 Williamson, Adele Kim; Grgic, Miriam; Leiros, Hanna-Kirsti S..
DNA binding with a minimal scaffold: structure-function analysis of Lig E DNA ligases. Nucleic Acids Research (NAR) 2018 ;Volum 46.(16) s. 8616-8629
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27 Williamson, Adele Kim; Hjerde, Erik; Sarre, Aili; Leiros, Ingar; Berg, Kristel; Leiros, Hanna-Kirsti S..
Discovery and design of novel DNA ligases for biotechnology. 6th International Conference on Novel Enzymes 2018; 2018-10-09 - 2018-10-12
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2017
28 Bayer, Annette; Leiros, Hanna-Kirsti S.; Akhter, Sundus; Lund, Bjarte Aarmo; Christopeit, Tony; Ismael, Aya.
Towards Antibiotic Resistance Breakers: Fragment-Based Design of OXA- 48 Inhibitors. FRAGMENTS2017; 2017-03-05 - 2017-03-07
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29 Leiros, Hanna-Kirsti S..
Aiming for inhibitors towards beta-lactamases involved in antibiotic resistance, but starting with fragment screening. How is the progress?. Nordic Chemical Biology Network, Workshop in fragment screening.; 2017-06-01 - 2017-06-01
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30 Leiros, Hanna-Kirsti S..
Enzymer involvert i antibiotika resistens. NBS-nytt 2017 ;Volum 4. s. 34-35
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31 Leiros, Hanna-Kirsti S..
Fragment screening used successfully for detecting OXA, VIM or NDM inhibitors. 13th Beta-Lactamase Meeting; 2017-06-16
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32 Leiros, Hanna-Kirsti S..
Inhibitors can help fighting antibiotic resistance bacteria, but how do we find the best inhibitors?. 53rd NBS contact meeting; 2017-01-19 - 2017-01-22
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33 Leiros, Hanna-Kirsti S..
Kampen. Den livsfarlige resistensen.. Youtube.com [Internett] 2017-03-31
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34 Lund, Bjarte Aarmo.
The OXA-class of β-lactamases. A structural view on antibiotic resistance. Tromsø: UiT - Norges arktiske universitet 2017 (ISBN 978-82-8236-269-6) 94 s.
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35 Lund, Bjarte Aarmo; Thomassen, Ane Molden; Carlsen, Trine Josefine Olsen; Leiros, Hanna-Kirsti S..
Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2017 ;Volum 73.(10) s. 579-587
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36 Os, Vibeke; Skagseth, Susann; Leiros, Hanna-Kirsti S..
"Superbugs" skal ikke lengre få herje i fred, Vil gjenreise effekten av antibiotika.. https://uit.no/nyheter/ [Internett] 2017-03-30
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37 Skagseth, Susann; Akhter, Sundus; Paulsen, Marianne H.; Zeeshan, Muhammad; Lauksund, Silje; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.; Bayer, Annette.
Metallo-β-lactamase inhibitors by bioisosteric replacement: preparation, activity and binding. European Journal of Medicinal Chemistry 2017 ;Volum 135. s. 159-173
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38 Skagseth, Susann; Christopeit, Tony; Akhter, Sundus; Bayer, Annette; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S..
Structural insights into TMB-1 and the role of residues 119 and 228 in substrate and inhibitor binding. Antimicrobial Agents and Chemotherapy 2017 ;Volum 61:e02602-16.(8) s. 1-19
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39 Skagseth, Susann; Leiros, Hanna-Kirsti S..
Forskere vil gjenreise effekten av antibiotika. https://forskning.no/kortnytt/forskere-vil-gjenreise-effekten-av-antibiotika. Forskning.no [Fagblad] 2017-03-31
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40 Williamson, Adele Kim; Hjerde, Erik; Leiros, Hanna-Kirsti S.; Lian, Kjersti; Ramirez, Miguel A.; Patrick, Wayne M..
Beyond T4: discovery and design of DNA ligases for use in biotechnological applications. Cryo-EM Symposium; 2017-07-06 - 2017-07-07
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2016
41 Ahkter, Sundus; Lund, Bjarte Aarmo; Guttormsen, Yngve; Christopeit, Tony; Bayer, Annette; Leiros, Hanna-Kirsti S..
Addressing Antibiotic Resistance: Fragment-Based Design of OXA-48 Inhibitors. 31. Organisk Kjemisk Vintermøte; 2016-01-07 - 2016-01-10
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42 Christopeit, Tony; Albert, Anastasia; Leiros, Hanna-Kirsti S..
Discovery of a novel covalent non-β-lactam inhibitor of the metallo-β-lactamase NDM-1. Bioorganic & Medicinal Chemistry 2016 ;Volum 24.(13) s. 2947-2953
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43 Christopeit, Tony; Carlsen, Trine Josefine Olsen; Albert, Anastasia; Skagseth, Susann; Leiros, Hanna-Kirsti S..
Discovery of a Novel Covalent Inhibitor of the Metallo-beta-lactamase NDM-1. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø; 2016-01-21 - 2016-01-24
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44 Christopeit, Tony; Leiros, Hanna-Kirsti S..
Fragment-based discovery of inhibitor scaffolds targeting the metallo-β-lactamases NDM-1 and VIM-2. Bioorganic & Medicinal Chemistry Letters 2016 ;Volum 26.(8) s. 1973-1977
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45 Christopeit, Tony; Yang, Ke-Wu; Yang, Shao-Kang; Leiros, Hanna-Kirsti S..
The structure of the metallo-β-lactamase VIM-2 in complex with a triazolylthioacetamide inhibitor. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2016 ;Volum 72.(11) s. 813-819
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46 De Santi, Concetta; Leiros, Hanna-Kirsti S.; Di Scala, Alessia; de Pascale, Donatella; Altermark, Bjørn; Willassen, Nils Peder.
Biochemical characterization and structural analysis of a new cold-active and salt-tolerant esterase from the marine bacterium Thalassospira sp.. Extremophiles 2016 ;Volum 20.(3) s. 323-336
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47 Leiros, Hanna-Kirsti S..
Searching for inhibitors towards beta-lactamases involved in antibiotic resistance, starting with fragment screening. Can we reach into the clinic?. Seminar serie; 2016-10-05
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48 Lund, Bjarte Aarmo; Ahkter, Sundus; Guttormsen, Yngve; Christopeit, Tony; Bayer, Annette; Leiros, Hanna-Kirsti S..
Structure-guided drug design for the antibiotic resistance enzyme OXA-48. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø; 2016-01-21 - 2016-01-24
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49 Lund, Bjarte Aarmo; Akhter, Sundus; Guttormsen, Yngve; Christopeit, Tony; Isaksson, Johan; Bayer, Annette; Leiros, Hanna-Kirsti S..
Structure-guided drug design for the antibiotic resistance enzyme OXA-48. 7th Annual BioStruct Conference; 2016-08-25 - 2016-08-28
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50 Lund, Bjarte Aarmo; Christopeit, Tony; Ahkter, Sundus; Guttormsen, Yngve; Isaksson, Johan; Bayer, Annette; Leiros, Hanna-Kirsti S..
Structure-Guided Drug Design for the Antibiotic Resistance Enzyme OXA-48. ASM Microbe 2016; 2016-06-16 - 2016-06-20
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