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2021
1 Frøhlich, Christopher; Gama, João Alves; Harms, Klaus; Hirvonen, Viivi H. A.; Lund, Bjarte Aarmo; van der Kamp, Marc W.; Johnsen, Pål Jarle; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S..
Cryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations. mSphere 2021
UiT Untitled
 
2 Gladstone, Rebecca Ashley; McNally, Alan; Pöntinen, Anna Kaarina; Tonkin-Hill, Gerry; Lees, John A.; Skytén, Kusti Onni; Cléon, Francois Pierre Alexandre; Christensen, Martin Owczarek Korsner; Haldorsen, Bjørg; Bye, Kristina K.; Gammelsrud, Karianne Wiger; Hjetland, Reidar; Kümmel, Angela; Larsen, Hege; Lindemann, Paul Christoffer; Löhr, Iren Høyland; Marvik, Åshild; Nilsen, Einar; Noer, Marie Therese; Simonsen, Gunnar Skov; Steinbakk, Martin; Tofteland, Ståle; Vattøy, Marit; Bentley, Stephen D.; Croucher, Nicholas J.; Parkhill, Julian; Johnsen, Pål Jarle; Samuelsen, Ørjan; Corander, Jukka.
Emergence and dissemination of antimicrobial resistance in Escherichia coli causing bloodstream infections in Norway in 2002–17: a nationwide, longitudinal, microbial population genomic study. The Lancet Microbe 2021 s. 1-11
AHUS FHI HAUKELAND HELSEFØRDE HMR HNT NLSH OSTFSYK OUS SIV SSHF SUS UiO UiT UNN Untitled
 
2020
3 Alves Gama, Joao Pedro; Kloos, Julia Maria; Johnsen, Pål Jarle; Samuelsen, Ørjan.
Host dependent maintenance of a blaNDM-1-encoding plasmid in clinical Escherichia coli isolates. Scientific Reports 2020 ;Volum 10:9332. s. 1-7
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4 Frøhlich, Christopher; Sørum, Vidar; Huber, Sandra; Samuelsen, Ørjan; Berglund, Fanny; Kristiansson, Erik; Kotsakis, Stathis D.; Marathe, Nachiket; Larsson, DG Joakim; Leiros, Hanna-Kirsti Schrøder.
Structural and biochemical characterization of the environmental MBLs MYO-1, ECV-1 and SHD-1. Journal of Antimicrobial Chemotherapy 2020 ;Volum 75. s. 2554-2563
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5 Leiros, Hanna-Kirsti S.; Thomassen, Ane Molden; Samuelsen, Ørjan; Flach, Carl-Fredrik; Kotsakis, Stathis D.; Larsson, Joakim.
Structural insights into the enhanced carbapenemase efficiency of OXA-655 compared to OXA-10. FEBS Open Bio 2020 ;Volum 10.(9) s. 1821-1832
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6 Ludden, Catherine; Lötsch, Felix; Alm, Erik; Kumar, Narender; Johansson, Karin; Albiger, Barbara; Huang, Te-Din; Denis, Olivier; Hammerum, Anette M.; Hasman, Henrik; Jalava, Jari; Räisänen, Kati; Dortet, Laurent; Jousset, Agnès B.; Gatermann, Sören; Haller, Sebastian; Cormican, Martin; Brennan, Wendy; Grosso, Maria Del; Monaco, Monica; Schouls, Leo; Samuelsen, Ørjan; Pirš, Mateja; Cerar, Tjaša; Oteo-Iglesias, Jésus; Pérez-Vázquez, Maria; Sjöström, Karin; Edquist, Petra; Hopkins, Katie L.; Struelens, Marc J.; Palm, Daniel; Monnet, Dominique L.; Kohlenberg, Anke.
Cross-border spread of blaNDM-1- and blaOXA-48-positive Klebsiella pneumoniae: a European collaborative analysis of whole genome sequencing and epidemiological data, 2014 to 2019. Eurosurveillance 2020 ;Volum 25.(20) s. -
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7 Pedersen, Torunn Annie; Tellevik, Marit Gjerde; Kommedal, Øyvind; Lindemann, Paul Christoffer; Moyo, Sabrina John; James Peter, Jessin Janice; Blomberg, Bjørn; Samuelsen, Ørjan; Langeland, Nina.
Horizontal plasmid transfer among klebsiella pneumoniae isolates is the key factor for dissemination of extended-spectrum β-lactamases among children in Tanzania. mSphere 2020 ;Volum 5:e00428-20.(4) s. 1-13
HAUKELAND HVprivate UiB UiT UNN Untitled
 
8 Samuelsen, Ørjan; Åstrand, Ove Alexander Høgmoen; Frøhlich, Christopher; Heikal, Adam; Skagseth, Susann; Carlsen, Trine Josefine Olsen; Leiros, Hanna-Kirsti S.; Bayer, Annette; Schnaars, Christian; Kildahl-Andersen, Geir; Lauksund, Silje; Finke, Sarah; Huber, Sandra; Gjøen, Tor; Andresen, Adriana Magalhaes Santos; Økstad, Ole Andreas; Rongved, Pål.
ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo. Antimicrobial Agents and Chemotherapy 2020 ;Volum 64.(6) s. -
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2019
9 Kildahl-Andersen, Geir; Schnaars, Christian; Prandina, Anthony; Radix, Sylvie; Le Borgne, Marc; Jordheim, Lars Petter; Gjøen, Tor; Andresen, Adriana Magalhaes Santos; Lauksund, Silje; Fröhlich, Christopher; Samuelsen, Ørjan; Rongved, Pål; Åstrand, Ove Alexander Høgmoen.
Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors. MedChemComm 2019 ;Volum 10.(4) s. 528-537
UiO UiT UNN Untitled
 
10 Elstrøm, Petter; Astrup, Elisabeth; Hegstad, Kristin; Samuelsen, Ørjan; Enger, Hege; Kacelnik, Oliver.
The fight to keep resistance at bay, epidemiology of carbapenemase producing organisms (CPOs), vancomycin resistant enterococci (VRE) and methicillin resistant Staphylococcus aureus (MRSA) in Norway, 2006-2017. PLOS ONE 2019 ;Volum 14:e0211741.(2) s. 1-17
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11 Frøhlich, Christopher; Johnsen, Pål Jarle; Schrøder Leiros, Hanna-Kirsti; Samuelsen, Ørjan.
Evolution of OXA-48 under sub-MIC conditions. 3rd Annual Meeting of the National Graduate School in Infection Biology and and Antimicrobials; 2019-11-05 - 2019-11-06
UiT Untitled
 
12 Frøhlich, Christopher; Leiros, Hanna-Kirsti S.; Johnsen, Pål Jarle; Samuelsen, Ørjan.
Sub-inhibitory concentrations of ceftazidime drive evolution of the OXA-48 carbapenemase. ECCMID 2019; 2019-04-13 - 2019-04-16
UiT Untitled
 
13 Frøhlich, Christopher; Sørum, Vidar; Thomassen, Ane Molden; Johnsen, Pål Jarle; Leiros, Hanna-Kirsti S.; Samuelsen, Ørjan.
OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs. mSphere 2019 ;Volum 4.(2)
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14 Prandina, Anthony; Radix, Sylvie; Le Borgne, Marc; Jordheim, Lars Petter; Bousfiha, Zineb; Fröhlich, Christopher; Leiros, Hanna-Kirsti S.; Samuelsen, Ørjan; Frøvold, Espen; Rongved, Pål; Åstrand, Ove Alexander Høgmoen.
Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors. Tetrahedron 2019 ;Volum 75.(11) s. 1525-1540
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15 Sørum, Vidar; Sollied Møller, Anna; Abel, Sören; Samuelsen, Ørjan; Podnecky, Nicole L.; Johnsen, Pål Jarle.
Evolutionary stability of collateral effects in ciprofloxacin resistant clinical Escherichia coli strains. Frampeik; 2019-10-11 - 2019-10-13
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16 Sørum, Vidar; Sollied Møller, Anna; Johnsen, Pål Jarle; Samuelsen, Ørjan; Abel, Sören; Podnecky, Nicole L..
Evolutionary stability of collateral effects in ciprofloxacin resistant clinical Escherichia coli strains. Annual IBA meeting; 2019-11-04 - 2019-11-05
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17 Sørum, Vidar; Øynes, Emma Lu; Møller, Anna; Podnecky, Nicole L.; Abel, Sören; Samuelsen, Ørjan; Johnsen, Pål Jarle.
Evolutionary stability of collateral susceptibility networks in clinical Escherichia coli strains. ECCMID 2019; 2019-04-13
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18 Zykov, Ilya Nikolaevich; Frimodt-Møller, Niels; Småbrekke, Lars; Sundsfjord, Arnfinn; Samuelsen, Ørjan.
Efficacy of mecillinam against clinical multidrug-resistant Escherichia coli in a murine urinary tract infection model. International Journal of Antimicrobial Agents 2019 ;Volum 55.(2) s. -
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2018
19 Frøhlich, Christopher; Sørum, Vidar; Leiros, Hanna-Kirsti S.; Johnsen, Pål Jarle; Samuelsen, Ørjan.
Development of OXA-48 mediated ceftazidme-avibactam resistance is associated with an evolutionary trade-off. ECCMID; 2018-04-24
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20 Haldorsen, Bjørg; Giske, Christian G; Hansen, Dennis S; Helgason, Kristjan Orri; Kahlmeter, Gunnar; Löhr, Iren Høyland; Matuschek, Erika; Österblad, Monica; Rantakokko-Jalava, Kaisu; Wang, Mikala; Småbrekke, Lars; Samuelsen, Ørjan; Sundsfjord, Arnfinn.
Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study.. Journal of Antimicrobial Chemotherapy 2018 ;Volum 73.(10) s. 2738-2747
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21 Jakovljev, Aleksandra; Afset, Jan Egil; Haugum, Kjersti; Rønning, Torunn Gresdal; Steinum, Harald Otto; Samuelsen, Ørjan; Gabrielsen, Christina.
"Escherichia coli sepsis: casus presentasjon med uvanlig resistensmønster". Vårmøtet 2018 Norsk Forening for Medisinsk mikrobiologi; 2018-05-31 - 2018-06-01
NTNU STO UiT Untitled
 
22 Kloos, Julia Maria; Alves Gama, Joao Pedro; Samuelsen, Ørjan; Johnsen, Pål Jarle.
Klebsiella pneumoniae MDR-encoding plasmids in clinical isolates of uropathogenic Escherichia coli: plasmid-host co-evolution and its effect on fitness cost of plasmid-mediated resistance. Plasmid Biology Symposium; 2018-08-05 - 2018-08-10
UiT Untitled
 
23 Kloos, Julia Maria; Alves Gama, Joao Pedro; Samuelsen, Ørjan; Johnsen, Pål Jarle.
Plasmid-host co-evolution of Klebsiella pneumoniae MDR-encoding plasmids in clinical isolates of uropathogenic Escherichia coli: effect on fitness cost of plasmid-mediated resistance. IBA Annual Meeting; 2018-11-08
UiT Untitled
 
24 Pedersen, Torunn Annie; Sekyere, John Osei; Govinden, Usha; Moodley, Krishnee; Sivertsen, Audun; Samuelsen, Ørjan; Essack, Sabiha Yusuk; Sundsfjord, Arnfinn.
Spread of plasmid-encoded NDM-1 and GES-5 carbapenemases among extensively drug-resistant and pandrug-resistant clinical enterobacteriaceae in durban, South Africa. Antimicrobial Agents and Chemotherapy 2018 ;Volum 62.(5)
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25 Podnecky, Nicole L.; Aarag, Elizabeth; Kloos, Julia Maria; Sørum, Vidar; Primicerio, Raul; Roberts, Adam Paul; Rozen, Daniel E.; Samuelsen, Ørjan; Johnsen, Pål Jarle.
Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli.. Nature Communications 2018 ;Volum 9:3673. s. 1-11
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26 Rapp, Ellionor; Samuelsen, Ørjan; Sundqvist, Martin.
Detection of carbapenemases with a newly developed commercial assay using Matrix Assisted Laser Desorption Ionization-Time of Flight. Journal of Microbiological Methods 2018 ;Volum 146. s. 37-39
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27 Roer, Louise; Overballe-Petersen, Søren; Hansen, Frank; Schønning, Kristian; Wang, Mikala; Røder, Bent L; Hansen,, Dennis S; Justesen, Ulrik S; Andersen, Leif P; Fulgsang-Damgaard, David; Hopkins, Katie L; Woodford, Neil; Falgenhauer, Linda; Chakraborty, Trinad; Samuelsen, Ørjan; Sjöström, Karin; Johannesen, Thor B; Ng, Kim; Nielsen, Jens; Ethelberg, Steen; Stegger, Marc; Hammerum, Anette M.; Hasman, Henrik.
Escherichia coli Sequence Type 410 Is Causing New International High-Risk Clones. mSphere 2018 ;Volum 3.(4)
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28 Samuelsen, Ørjan; Hansen, Frank; Aasnæs, Bettina; Hasman, Henrik; Lund, Bjarte Aarmo; Leiros, Hanna-Kirsti S.; Lilje, Berit; James Peter, Jessin Janice; Jakobsen, Lotte; Littauer, Pia; Søes, Lillian M; Holzknecht, Barbara J.; Andersen, Leif P; Stegger, Marc; Andersen, Paal S.; Hammerum, Anette M..
Dissemination and Characteristics of a Novel Plasmid-Encoded Carbapenem-Hydrolyzing Class D β-Lactamase, OXA-436, Found in Isolates from Four Patients at Six Different Hospitals in Denmark. Antimicrobial Agents and Chemotherapy 2018 ;Volum 62.(1)
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29 Schnaars, Christian; kildahl-Andersen, Geir; Prandina, Anthony; Popal, Roya; Radix, Sylvie; Le Borgne, Marc; Gjøen, Tor; Andresen, Adriana Magalhaes Santos; Heikal, Adam; Økstad, Ole Andreas Løchen; Fröhlich, Christopher; Samuelsen, Ørjan; Lauksund, Silje; Jordheim, Lars Petter; Rongved, Pål; Åstrand, Ove Alexander Høgmoen.
Synthesis and preclinical evaluation of TPA-based zinc chelators as metallo-β-lactamase inhibitors. ACS Infectious Diseases 2018 ;Volum 4.(9) s. 1407-1422
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30 Taiaroa, George; Samuelsen, Ørjan; Kristensen, Tom; Økstad, Ole Andreas; Heikal, Adam.
Complete Genome Sequence of Pseudomonas aeruginosa K34-7, a Carbapenem-Resistant Isolate of the High-Risk Sequence Type 233. Microbiology Resource Announcements (MRA) 2018 ;Volum 7.(4) s. 1-2
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31 Zykov, Ilya Nikolaevich; Samuelsen, Ørjan; Jakobsen, Lotte; Småbrekke, Lars; Andersson, Dan I.; Sundsfjord, Arnfinn; Frimodt-Møller, Niels.
Pharmacokinetics and pharmacodynamics of fosfomycin and its activity against extended-spectrum-lactamase-, plasmid-mediated AmpC-, and carbapenemase-producing escherichia coli in a murine urinary tract infection model. Antimicrobial Agents and Chemotherapy 2018 ;Volum 62.(6)
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2017
32 Berg, Einar Sverre; Wester, Astrid Lousie; Ahrenfeldt, J; Mo, Solveig Sølverød; Slettemeås, Jannice Schau; Steinbakk, Martin; Samuelsen, Ørjan; Grude, Nils; Simonsen, Gunnar Skov; Löhr, Iren Høyland; Jørgensen, Silje; Tofteland, Ståle; Lund, O.; Dahle, Ulf R; Sunde, Marianne.
Norwegian patients and retail chicken meat share cephalosporin-resistant Escherichia coli and IncK/blaCMY-2 resistance plasmids. Clinical Microbiology and Infection (CMI) 2017 ;Volum 23.(6) s. 407.e9-407.e15
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33 Charnock, Colin; Samuelsen, Ørjan; Nordlie, Anne-Lise; Hjeltnes, Bjarne.
Use of a Commercially Available Microarray to Characterize Antibiotic-Resistant Clinical Isolates of Klebsiella pneumoniae. Current Microbiology 2017 s. 1-10
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34 Ellington, Matthew J.; Ekelund, Oskar; Aarestrup, Frank Møller; Cantón, Rafael; Doumith, Michel; Giske, Christian G.; Grundman, Hajo; Hasman, Henrik; Holden, Matthew T.G.; Hopkins, Katie L.; Iredell, Jonathan R.; Kahlmeter, Gunnar; Köser, Claudio U.; MacGowan, Alasdair Peter; Mevius, Dik; Mulvey, Michael Richard; Naas, Thierry P.; Peto, Tim E.; Rolain, Jean-Marc; Samuelsen, Ørjan; Woodford, Neil.
The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria: report from the EUCAST Subcommittee. Clinical Microbiology and Infection (CMI) 2017 ;Volum 23.(1) s. 2-22
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35 Heikal, Adam; Samuelsen, Ørjan; Kristensen, Tom; Økstad, Ole Andreas Løchen.
Complete genome sequence of a multidrug-resistant, blaNDM-1-expressing Klebsiella pneumoniae K66-45 clinical isolate from Norway. Microbiology Resource Announcements (MRA) 2017 ;Volum 5:e00601.(27) s. 1-2
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36 Jakovljev, Aleksandra; Afset, Jan Egil; Haugum, Kjersti; Steinum, Harald Otto; Rønning, Torunn Gresdal; Samuelsen, Ørjan; Gabrielsen, Christina.
Genetic basis of growth characteristics and trimethoprim-sulfamethoxazole susceptibility of thymine-dependent and thymine-independent serial blood culture isolates of Escherichia coli. 27th ECCMID 2017, 22-25 April, Vienna, Austria; 2017-04-22 - 2017-04-25
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37 Knudsen, Per Kristian; Brandtzæg, Petter; Høiby, Ernst Arne; Bohlin, Jon; Samuelsen, Ørjan; Steinbakk, Martin; Abrahamsen, Tore G; Müller, Fredrik; Gammelsrud, Karianne Wiger.
Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting. PLOS ONE 2017 ;Volum 12.(11) s. -
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38 Lund, Bjarte Aarmo.
The OXA-class of β-lactamases. A structural view on antibiotic resistance. Tromsø: UiT - Norges arktiske universitet 2017 (ISBN 978-82-8236-269-6) 94 s.
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39 Samuelsen, Ørjan; Overballe-Petersen, Søren; Bjørnholt, Jørgen; Brisse, Sylvain; Doumith, Michel; Woodford, Neil; Hopkins, Katie L.; Aasnæs, Bettina; Haldorsen, Bjørg; Sundsfjord, Arnfinn.
Molecular and epidemiological characterization of carbapenemase-producing Enterobacteriaceae in Norway, 2007 to 2014. PLOS ONE 2017 ;Volum 12.(11) s. -
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40 Skagseth, Susann; Akhter, Sundus; Paulsen, Marianne H.; Zeeshan, Muhammad; Lauksund, Silje; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.; Bayer, Annette.
Metallo-β-lactamase inhibitors by bioisosteric replacement: preparation, activity and binding. European Journal of Medicinal Chemistry 2017 ;Volum 135. s. 159-173
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41 Skagseth, Susann; Christopeit, Tony; Akhter, Sundus; Bayer, Annette; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S..
Structural insights into TMB-1 and the role of residues 119 and 228 in substrate and inhibitor binding. Antimicrobial Agents and Chemotherapy 2017 ;Volum 61:e02602-16.(8) s. 1-19
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2016
42 Di Luca, Maria Chiara; Skaare, Dagfinn; Aasnæs, Bettina; Sundsfjord, Arnfinn; Samuelsen, Ørjan.
Identification of a novel IMI carbapenemase variant (IMI-9) in Enterobacter cloacae complex. International Journal of Antimicrobial Agents 2016 ;Volum 48.(6) s. 764-765
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43 Di Luca, Maria Chiara; Sørum, Vidar; Starikova, Irina; Kloos, Julia Maria; Hülter, Nils Fredrik; Naseer, Mohammed Umaer; Johnsen, Pål Jarle; Samuelsen, Ørjan.
Low biological cost of carbapenemase-encoding plasmids following transfer from Klebsiella pneumoniae to Escherichia coli. Journal of Antimicrobial Chemotherapy 2016 ;Volum 72.(1) s. 85-89
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44 Jakovljev, Aleksandra; Afset, Jan Egil; Haugum, Kjersti; Steinum, Harald Otto; Rønning Gresdal, Torunn; Samuelsen, Ørjan; Gabrielsen, Christina.
Undersøkelse av det genetiske grunnlaget for fenotypiske forskjeller i vekstegenskaper og følsomhet overfor trimetoprim-sulfamethoxazole hos Escherichia coli isolert fra pasient med residiverende bakteriemiepisoder. Årskonferanse FHI 2016; 2016-12-01 - 2016-12-02
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45 Onarheim, Henning; Brekke, Ragnvald Ljones; Leiva, Rafael Alexander Mo; Oma, Dorthea Hagen; Kolstad, Helge; Samuelsen, Ørjan; Sundsfjord, Arnfinn; Mylvaganam, Haima.
En kvinne med sepsis etter brannskade i Pakistan. Tidsskrift for Den norske legeforening 2016 ;Volum 136.(14) s. 1228-1232
HAUKELAND UiB UiT UNN Untitled
 
46 Onarheim, Henning; BREKKE, RAGNVALD LJONES; Leiva, Rafael Alexander Mo; Oma, Dorthea Hagen; Kolstad, Helge; Samuelsen, Ørjan; Sundsfjord, Arnfinn; Mylvaganam, Haima.
H. Onarheim og medarbeidere svarer. Tidsskrift for Den norske legeforening 2016 ;Volum 136.(17) s. 1424-1425
HAUKELAND UiB UiT UNN Untitled
 
47 Skagseth, Susann; Carlsen, Trine Josefine Olsen; Bjerga, Gro Elin Kjæreng; Spencer, James; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S..
Role of residues W228 and Y233 in the structure and activity of metallo-β-lactamase GIM-1. Antimicrobial Agents and Chemotherapy 2016 ;Volum 60.(2) s. 990-1002
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48 Skagseth, Susann; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S..
The impact of residues 119 and 228 in the Tripoli metallo-beta-lactamase TMB-1 involved in resistance to beta-lactam antibiotics. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø; 2016-01-21 - 2016-01-24
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2015
49 Berg, Einar Sverre; Wester, Astrid Lousie; Mo, Solveig Sølverød; Slettemeås, Jannice Schau; Steinbakk, Martin; Dahle, Ulf R; Samuelsen, Ørjan; Simonsen, Gunnar Skov; Löhr, Iren Høyland; Jørgensen, Silje; Sunde, Marianne.
Highly similar cephalosporin resistant Escherichia coli and AmpC resistance plasmids found in both patients and poultry meat in Norway. ECCMID; 2015-04-25 - 2015-04-28
AHUS FHI SUS UiO UiT VETINST Untitled
 
50 Christopeit, Tony; Carlsen, Trine Josefine Olsen; Skagseth, Susann; Lund, Bjarte Aarmo; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S..
Using fragment screening to identify novel starting points for potent inhibitors of metallo-beta-lactamase VIM-2. Fragments 2015: Fifth RSC-BMCS Fragment-based Drug Discovery meeting; 2015-03-22 - 2015-03-22
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