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2019
1 Falnes, Pål Øystein.
Regulation of protein synthesis through methylation of human eukaryotic elongation factor 1 alpha (eEF1A). Norwegian Biochemical Society 55th Contact Meeting; 2019-01-24 - 2019-01-27
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2 Malecki, Jedrzej Mieczyslaw; Willemen, Hanneke L.D.M.; Pinto, Rita; Ho, Angela Yeuan Yen; Moen, Anders; Eijkelkamp, Niels; Falnes, Pål Øystein.
Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration. Journal of Biological Chemistry 2019 ;Volum 294. s. 11654-11664
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2018
3 Falnes, Pål Øystein.
Discovering new human enzymes involved in methylation and demethylation of nucleic acids and proteins. Foredrag for PhD studenter og forskere; 2018-02-26
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4 Falnes, Pål Øystein.
Regulation of human eukaryotic elongation factor 1 alpha (eEF1A) by lysine methylation. FASEB Science Research Conferences: "Biological methylation"; 2018-06-17 - 2018-06-22
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5 Jakobsson, Magnus; Malecki, Jedrzej Mieczyslaw; Falnes, Pål Øystein.
Regulation of eukaryotic elongation factor 1 alpha (eEF1A) by dynamic lysine methylation. RNA Biology 2018 ;Volum 15.(3) s. 314-319
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6 Jakobsson, Magnus; Malecki, Jedrzej Mieczyslaw; Halabelian, Levon; Nilges, Benedikt S.; Pinto, Rita; Kudithipudi, Srikanth; Munk, Stephanie; Davydova, Erna; Zuhairi, Fawsi Rahmadiyan; Arrowsmith, Cheryl H; Jeltsch, Albert; Leidel, Sebastian A.; Olsen, Jesper V.; Falnes, Pål Øystein.
The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates. Nature Communications 2018 ;Volum 9:3411. s. 1-15
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7 Malecki, Jedrzej Mieczyslaw; Willemen, Hanneke L.D.M.; Pinto, Rita; Ho, Angela Yeuan Yen; Moen, Anders; Kjønstad, Ingrid Fadum; Burgering, Boudewijn M.T.; Zwartkruis, Fried; Eijkelkamp, Niels; Falnes, Pål Øystein.
Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase. Journal of Biological Chemistry 2018 ;Volum 294.(4) s. 1128-1141
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8 Willemen, Hanneke L.D.M.; Kavelaars, Annemieke; Prado, Judith; Maas, MIrjam; Versteeg, Sabine; Nellissen, Lara J.J.; Tromp, Jeshua; Gonzalez Cano, Rafael; Zhou, Wenjun; Jakobsson, Magnus; Malecki, Jedrzej Mieczyslaw; Posthuma, George; Habib, Abdella; Heijnen, Cobi J.; Falnes, Pål Øystein; Eijkelkamp, Niels.
Identification of FAM173B as a protein methyltransferase promoting chronic pain. PLoS Biology 2018 ;Volum 16.(2) s. -
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2017
9 Aileni, Vinay Kumar; Davydova, Erna; Moen, Anders; Falnes, Pål.
A System for Enzymatic Lysine Methylation in a Desired Sequence Context. ACS Omega 2017 ;Volum 2.(2) s. 462-469
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10 Falnes, Pål.
Identification and characterisation of lysine-specific methyltransferases in humans. NBS Kontaktmøte; 2017-01-20
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11 Jakobsson, Magnus; Malecki, Jedrzej Mieczyslaw; Nilges, Benedikt S.; Moen, Anders; Leidel, Sebastian A.; Falnes, Pål.
Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation. Nucleic Acids Research 2017 ;Volum 45. s. 8239-8254
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12 Malecki, Jedrzej Mieczyslaw; Aileni, Vinay Kumar; Ho, Angela Yeuan Yen; Schwarz, Juliane; Moen, Anders; Sørensen, Vigdis; Nilges, Benedikt S.; Jakobsson, Magnus; Leidel, Sebastian A.; Falnes, Pål.
The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A). Nucleic Acids Research 2017 ;Volum 45.(8) s. 4370-4389
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13 Malecki, Jedrzej Mieczyslaw; Jakobsson, Magnus; Ho, Angela Yeuan Yen; Moen, Anders; Rustan, Arild; Falnes, Pål.
Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation. Journal of Biological Chemistry 2017 ;Volum 292.(43) s. 17950-17962
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2016
14 Aileni, Vinay Kumar; Davydova, Erna; Kernstock, Jens Stefan; Moen, Anders; Falnes, Pål.
VCP-KMT (METTL21D)-mediated lysine methylation of histone H3 peptide sequences grafted onto a VCP-derived scaffold. "Biological methylation: Fundamental mechanisms in health and disease"; 2016-06-21
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15 Falnes, Pål.
Lysine methylation of non-histone proteins - new enzymes, new functions. Departmental seminar; 2016-04-19
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16 Falnes, Pål.
Metylering av DNA og proteiner - både skadelig og nødvendig. BIO-torsdag; 2016-09-29
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17 Falnes, Pål; Jakobsson, Magnus; Davydova, Erna; Ho, Angela Yeuan Yen; Malecki, Jedrzej Mieczyslaw.
Protein lysine methylation by seven-β-strand methyltransferases. Biochemical Journal 2016 ;Volum 473.(14) s. 1995-2009
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18 Jakobsson, Magnus; Moen, Anders; Davidson, Ben; Falnes, Pål.
METTL21A-catalysed lysine methylation of Hsp70 proteins. "Biological methylation: Fundamental mechanisms in health and disease; 2016-06-20
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19 Jakobsson, Magnus; Moen, Anders; Falnes, Pål.
Correspondence: On the enzymology and significance of HSPA1 lysine methylation. Nature Communications 2016 ;Volum 7.
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20 Malecki, Jedrzej Mieczyslaw; Dahl, Helge-Andre; Moen, Anders; Davydova, Erna; Falnes, Pål.
The METTL20 homologue from agrobacterium tumefaciens is a dual specificity protein-lysine methyltransferase that targets ribosomal protein L7/L12 and the β subunit of electron transfer flavoprotein (ETFβ). Journal of Biological Chemistry 2016 ;Volum 291.(18) s. 9581-9595
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2015
21 Falnes, Pål.
Discovering new human enzymes involved in methylation and demethylation of nucleic acids and proteins. Departmental seminar; 2015-03-04
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22 Falnes, Pål.
Discovering new human enzymes involved in methylation and demethylation of nucleic acids and proteins. Departmental Seminar; 2015-04-13
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23 Falnes, Pål.
Merkelapper på DNA og proteiner – både skadelig og nødvendig.. "Bestill en kreftforsker"; 2015-11-05
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24 Falnes, Pål.
Metylering av DNA og proteiner– skadelig og nødvendig. Faglig-pedagogisk dag, UiO (for lærere i videregående skole); 2015-10-29
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25 Falnes, Pål; Ho, Angela Yeuan Yen.
Role of ALKBH8 in the Synthesis of Wobble Uridine Modifications in tRNA. I: 2-Oxoglutarate-Dependent Oxygenases. Royal Society of Chemistry 2015 ISBN 978-1-84973-950-4. s. 275-288
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26 Fusser, Markus; Kernstock, Stefan; Aileni, Vinay Kumar; Jacobsen, Wolfgang Mathias; Falnes, Pål; Klungland, Arne.
Lysine methylation of the valosin-containing protein (VCP) is dispensable for development and survival of mice. PLOS ONE 2015 ;Volum 10.(11) s. -
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27 Jakobsson, Magnus; Davydova, Erna; Malecki, Jedrzej Mieczyslaw; Moen, Anders; Falnes, Pål.
Saccharomyces cerevisiae eukaryotic elongation factor 1A (eEF1A) is methylated at Lys-390 by a METTL21-like methyltransferase. PLOS ONE 2015 ;Volum 10.(6)
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28 Jakobsson, Magnus; Moen, Anders; Davidson, Ben; Falnes, Pål.
Hsp70 (HSPA1) lysine methylation status as a potential prognostic factor in metastatic high-grade serous carcinoma. PLOS ONE 2015 ;Volum 10:e0140168.(10)
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29 Malecki, Jedrzej Mieczyslaw; Ho, Angela Yeuan Yen; Moen, Anders; Dahl, Helge-Andre; Falnes, Pål.
Human METTL20 is a mitochondrial lysine methyltransferase that targets the β subunit of electron transfer flavoprotein (ETFβ) and modulates its activity. Journal of Biological Chemistry 2015 ;Volum 290.(1) s. 423-434
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30 Zdzalik, Daria; Domanska, Anna; Prorok, Paulina; Kosicki, Konrad; Van den Born, Erwin; Falnes, Pål; Rizzo, Carmelo J.; Guengerich, F.Peter; Tudek, Barbara.
Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins. DNA Repair 2015 ;Volum 30. s. 1-10
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2014
31 Davydova, Erna; Ho, Angela Yeuan Yen; Malecki, Jedrzej Mieczyslaw; Moen, Anders; Enserink, Jorrit; Jakobsson, Magnus; Loenarz, Christoph; Falnes, Pål.
Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2). Journal of Biological Chemistry 2014 ;Volum 289.(44) s. 30499-30510
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32 Falnes, Pål.
Discovering new human enzymes involved in methylation and demethylation of nucleic acids and proteins. Biochemistry Department Seminar; 2014-12-10 - 2014-12-10
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33 Falnes, Pål.
Functional characterization of a novel family of protein lysine methyltransferases. FASEB Science Research Conference on Biological Methylation; 2014-07-06 - 2014-07-12
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34 Zdzalik, Daria; Vågbø, Cathrine Broberg; Kirpekar, F; Davydova, Erna; Puścian, Alicja; Maciejewska, Agnieszka M.; Krokan, Hans Einar; Klungland, Arne; Tudek, Barbara; Van den Born, Erwin; Falnes, Pål.
Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities. PLOS ONE 2014 ;Volum 9.(6)
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2013
35 Falnes, Pål.
Role of the bifunctional ALKBH8 enzyme in the formation of modified wobble uridines in tRNA. Barcelona BioMed Conference Gene Translation: Fidelity and Quality Control; 2013-12-01 - 2013-12-04
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36 Jakobsson, Magnus; Moen, Anders; Bousset, Luc; Jacobsen, Wolfgang Mathias; Kernstock, Jens Stefan; Melki, Ronald; Falnes, Pål.
Identification and characterization of a novel human methyltransferase modulating hsp70 Protein function through lysine methylation. Journal of Biological Chemistry 2013 ;Volum 288.(39) s. 27752-27763
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37 Lin, Fu-Jung; Shen, Li; Jang, Chuan-Wei; Falnes, Pål; Zhang, Yi.
Ikbkap/Elp1 Deficiency Causes Male Infertility by Disrupting Meiotic Progression. PLoS Genetics 2013 ;Volum 9.(5) s. -
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2012
38 Bjørnstad, Linn; Meza, Trine Johansen; Otterlei, Marit; Olafsrud, Solveig Mjelstad; Meza-Zepeda, Leonardo Andrés; Falnes, Pål.
Human ALKBH4 Interacts with Proteins Associated with Transcription. PLOS ONE 2012 ;Volum 7.(11) s. -
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39 Falnes, Pål.
Merkelapper på DNA og proteiner – både skadelig og nødvendig. "Bestill en kreftforsker; 2012-10-24
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40 Falnes, Pål.
Merkelapper på DNA og proteiner –både skadelig og nødvendig. "Bestill en kreftforsker"; 2012-10-22
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41 Kernstock, Jens Stefan; Davydova, Erna; Jakobsson, Magnus; Moen, Anders; Pettersen, Solveig; Mælandsmo, Gunhild; Jacobsen, Wolfgang Mathias; Falnes, Pål.
Lysine methylation of VCP by a member of a novel human protein methyltransferase family. Nature Communications 2012 ;Volum 3. s. -
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42 Korvald, Hanne; Falnes, Pål; Lærdahl, Jon Kristen; Bjørås, Magnar; Alseth, Ingrun.
The Schizosaccharomyces pombe AlkB homolog Abh1 exhibits AP lyase activity but no demethylase activity. DNA Repair 2012 ;Volum 11.(5) s. 453-462
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43 Meza, Trine Johansen; Moen, Marivi; Vågbø, Cathrine Broberg; Krokan, Hans Einar; Klungland, Arne; Grini, Paul Eivind; Falnes, Pål.
The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage. Nucleic Acids Research 2012 ;Volum 40.(14) s. 6620-6631
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2011
44 Bjørnstad, Linn; Zoppellaro, Giorgio; Tomter, Ane Berg; Falnes, Pål; Andersson, K. Kristoffer.
Spectroscopic and Magnetic Studies of wild-type and mutant forms of the FeII and 2-oxoglutarate dependent decarboxylase ALKBH4. Biochemical Journal 2011 ;Volum 434.(3) s. 391-398
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45 Bjørnstad, Linn; Zoppellaro, Giorgio; Tomter, Ane Berg; Falnes, Pål; Andersson, K. Kristoffer.
Spectroscopic and Magnetic Studies of wild-type and mutant forms of the FeII and 2-oxoglutarate dependent decarboxylase ALKBH4. Gordon Research Conferences, Conference: Metals in Biology, Ventura California; 2011-01-30 - 2010-02-04; 2011-01-30 - 2011-02-04
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46 Leihne, VIbeke; Kirpekar, F; Vågbø, Cathrine Broberg; Van den Born, Erwin; Krokan, Hans Einar; Grini, Paul Eivind; Meza, Trine Johansen; Falnes, Pål.
Roles of Trm9-and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA. Nucleic Acids Research 2011 ;Volum 39.(17) s. 7688-7701
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47 Van den Born, Erwin; Vågbø, Cathrine Broberg; Songe-Møller, Lene; Leihne, VIbeke; Lien, Guro Flor; Leszczynska, G; Malkiewicz, A; Krokan, Hans Einar; Kirpekar, F; Klungland, Arne; Falnes, Pål.
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. Nature Communications 2011 ;Volum 2. s. -
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2010
48 Meza, Trine Johansen; Moen, Marivi N.; Vågbø, Cathrine B.; Ulleland, Marius; Krokan, Hans Einar; Arne, Klungland; Grini, Paul Eivind; Falnes, Pål Ø..
The DNA dioxygenase AtALKBH2 protects Arabidopsis thaliana against methylation damage. 9th Norwegian Arabidopsis Meeting; 2010-11-11 - 2010-11-11
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49 Songe-Møller, Lene; Van den Born, Erwin; Leihne, V; Vågbø, Cathrine Broberg; Kristoffersen, T; Krokan, Hans Einar; Kirpekar, F; Falnes, PO; Klungland, A.
Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding. Molecular and Cellular Biology 2010 ;Volum 30.(7) s. 1814-1827
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2009
50 Falnes, Pål.
AlkB-like dioxygenases - roles in nucleic acid repair and modification. Second Erling Seeberg Symposium on DNA repair; 2009-06-20 - 2009-06-25
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