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2019
1 Brennecke, Philip; Rasina, Dace; Aubi Catevilla, Oscar; Herzog, Katja; Landskron, Johannes; Cautain, Bastien; Vicente, Francisca; Quintana, Jordi; Mestres, Jordi; Stechmann, Bahne; Ellinger, Bernhard; Brea, Jose; Kolanowski, Jacek L.; Pilarski, Radosław; Orzáez, Mar; Pineda-Lucena, Antonio; Laraia, Luca; Nami, Faranak; Zielenkiewicz, Piotr; Paruch, Kamil; Hansen, Espen; von Kries, Jens P.; Neuenschwander, Martin; Specker, Edgar; Bartunek, Petr; Šímová, Šárka; Leśnikowski, Zbigniew; Krauss, Stefan; Lehtiö, Lari; Bilitewski, Ursula; Brönstrup, Mark; Tasken, Kjetil; Jirgensons, Aigars; Lickert, Heiko; Clausen, Mads H.; Andersen, Jeanette hammer; Vicent, Maria J.; Genilloud, Olga; Martinez, Aurora; Nazaré, Marc; Fecke, Wolfgang; Gribbon, Philip.
EU-OPENSCREEN: A novel collaborative approach to facilitate chemical biology. SLAS Discovery 2019 ;Volum 24.(3) s. 398-413
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2 Chellappa, Stalin; Kushekhar, Kushi; Munthe, Ludvig Andre; Tjønnfjord, Geir Erland; Aandahl, Einar Martin; Okkenhaug, Klaus; Tasken, Kjetil.
The PI3K p110δ isoform inhibitor idelalisib preferentially inhibits human regulatory T cell function. Journal of Immunology 2019 ;Volum 202.(5) s. 1397-1405
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3 Goodridge, Jodie; Jacobs, Benedikt Marcel; Sætersmoen, Michelle Lu; Clement, Dennis; Hammer, Quirin; Clancy, Trevor; Skarpen, Ellen; Brech, Andreas; Landskron, Johannes; Grimm, Christian; Pfefferle, Aline; Meza, Leonardo Zepeda; Lorenz, Susanne; Wiiger, Merete Thune; Louch, William Edward; Ask, Eivind Heggernes; Liu, Lisa L.; Oei, Vincent Yi Sheng; Kjällquist, Una; Linnarsson, Sten; Patel, Sandip; Tasken, Kjetil; Stenmark, Harald; Malmberg, Karl-Johan.
Remodeling of secretory lysosomes during education tunes functional potential in NK cells. Nature Communications 2019 ;Volum 10:14. s. 1-15
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4 Haug, Markus; Meås, Hany Zakaria; Beckwith, Marianne Sandvold; Louet, Claire; Ryan, Liv; Hu, Z.; Landskron, Johannes; Nordbø, Svein Arne; Tasken, Kjetil; Yin, H. H.; Damås, Jan Kristian; Flo, Trude Helen.
P1511 - Sensing of HIV-1 nucleic acids by TLR8 in human CD4+ T cells. European Journal of Immunology 2019 ;Volum 43. Suppl. S3 s. 1-2223
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5 Meås, Hany Zakaria; Haug, Markus; Beckwith, Marianne; Louet, Claire; Ryan, Liv; Landskron, Johannes; Nordbø, Svein Arne; Tasken, Kjetil; Damås, Jan Kristian; Flo, Trude Helen.
Sensing of HIV-1 by TLR8 activates human T cells and reverses Latency. Norsk Biokjemisk Selskap Kontaktmøte 2019; 2019-01-24 - 2019-01-27
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6 Skånland, Sigrid Strand; Tasken, Kjetil.
Carboxyl-terminal Src kinase binds CD28 upon activation and mutes downstream signaling. Journal of Immunology 2019 ;Volum 203.(4) s. 1055-1063
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2018
7 Dukic, Aleksandra; Gerbaud, Pascal; Guibourdenche, Jean; Thiede, Bernd; Tasken, Kjetil; Pidoux, Guillaume.
Ezrin-anchored PKA phosphorylates serine 369 and 373 on connexin 43 to enhance gap junction assembly, communication, and cell fusion. Biochemical Journal 2018 ;Volum 475.(2) s. 455-476
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8 Hermansen, Johanne Uthus; Tjønnfjord, Geir Erland; Munthe, Ludvig Andre; Tasken, Kjetil; Skånland, Sigrid Strand.
Cryopreservation of primary B cells minimally influences their signaling responses. Scientific Reports 2018 ;Volum 8:17651. s. 1-7
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9 Meås, Hany Zakaria; Haug, Markus; Beckwith, Marianne; Louet, Claire; Ryan, Liv; Landskron, Johannes; Nordbø, Svein Arne; Tasken, Kjetil; Damås, Jan Kristian; Flo, Trude Helen.
Sensing of HIV-1 by TLR8 activates human T cells and reverses Latency. Keystone HIV and Co-Infections: Pathogenesis, Inflammation and Persistence (X8); 2018-04-15 - 2018-04-19
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10 Myhrvold, Ida Kristin; Cremaschi, Andrea; Hermansen, Johanne Uthus; Tjønnfjord, Geir Erland; Munthe, Ludvig Andre; Tasken, Kjetil; Skånland, Sigrid Strand.
Single cell profiling of phospho-protein levels in chronic lymphocytic leukemia. OncoTarget 2018 ;Volum 9.(10) s. 9273-9284
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11 Rogne, Marie; Chu, Dinh Toi; Küntziger, Thomas M.; Mylonakou, Maria-Niki; Collas, Philippe; Tasken, Kjetil.
OPA1-anchored PKA phosphorylates perilipin 1 on S522 and S497 in adipocytes differentiated from human adipose stem cells. Molecular Biology of the Cell 2018 ;Volum 29.(12) s. 1487-1501
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12 Schwab, Charlotte; Gabrysch, Annemarie; Olbrich, Peter; Patiño, Virginia; Warnatz, Klaus; Wolff, Daniel; Hoshino, Akihiro; Kobayashi, Masao; Imai, Kohsuke; Takagi, Masatoshi; Dybedal, Ingunn; Haddock, Jamanda A.; Sansom, David M.; Lucena, Jose M.; Seidl, Maximilian; Schmitt-Graeff, Annette; Reiser, Veronika; Emmerich, Florian; Frede, Natalie; Bulashevska, Alla; Salzer, Ulrich; Schubert, Desirée; Hayakawa, Seiichi; Okada, Satoshi; Kanariou, Maria; Kucuk, Zeynep Yesim; Chapdelaine, Hugo; Petruzelkova, Lenka; Sumnik, Zdenek; Sediva, Anna; Slatter, Mary; Arkwright, Peter D.; Cant, Andrew; Lorenz, Hanns-Martin; Giese, Thomas; Lougaris, Vassilios; Plebani, Alessandro; Price, Christina; Sullivan, Kathleen E.; Moutschen, Michel; Litzman, Jiří; Freiberger, Tomas; van de Veerdonk, Frank L.; Recher, Mike; Albert, Michael H.; Hauck, Fabian; Seneviratne, Suranjith; Pachlopnik Schmid, Jana; Kolios, Antonios; Unglik, Gary; Klemann, Christian; Speckmann, Carsten; Ehl, Stephan; Leichtner, Alan; Blumberg, Richard; Franke, Andre; Snapper, Scott; Zeissig, Sebastian; Cunningham-Rundles, Charlotte; Giulino-Roth, Lisa; Elemento, Olivier; Dückers, Gregor; Niehues, Tim; Fronkova, Eva; Kanderová, Veronika; Platt, Craig D.; Chou, Janet; Chatila, Talal A.; Geha, Raif; McDermott, Elizabeth; Bunn, Su; Kurzai, Monika; Schulz, Ansgar; Alsina, Laia; Casals, Ferran; Deyà-Martinez, Angela; Hambleton, Sophie; Kanegane, Hirokazu; Tasken, Kjetil; Neth, Olaf; Grimbacher, Bodo.
Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects. Journal of Allergy and Clinical Immunology 2018 s. 1-15
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13 Tasken, Kjetil.
Need for competence and cross-disciplinary efforts between research and clinic in development of precision medicine strategies. Arendalsuka; 2018-08-15 - 2018-08-15
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14 Tasken, Kjetil.
Personalised Cancer Therapies (PerCaThe) – the biological perspectives. UiO:Life Science Conference, Symposium Convergence in Medicine; 2018-02-15 - 2018-02-15
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2017
15 Bains, Simer Jit; Mahic, Milada; Myklebust, Tor Åge; Småstuen, Milada C; Yaqub, Sheraz; Dørum, Liv Marit; Bjørnbeth, Bjørn Atle; Møller, Bjørn; Brudvik, Kristoffer Watten; Tasken, Kjetil.
Correspondence: Reply to M. Løberg et al. Aspirin, colorectal cancer and cause of Death - a complex landscape. Journal of Clinical Oncology 2017 ;Volum 35.(5) s. 569-571
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16 Bains, Simer Jit; Mahic, Milada; Myklebust, Tor Åge; Småstuen, Milada C; Yaqub, Sheraz; Dørum, Liv Marit; Bjørnbeth, Bjørn Atle; Møller, Bjørn; Brudvik, Kristoffer Watten; Tasken, Kjetil.
Reply to M. Løberg et al. Journal of Clinical Oncology 2017 ;Volum 35.(5) s. 569-570
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17 Chellappa, Stalin; Hugenschmidt, Harald; Hagness, Morten; Subramani, Saranya; Melum, Espen; Line, Pål Dag; Labori, Knut Jørgen; Wiedswang, Gro; Tasken, Kjetil; Aandahl, Einar Martin.
CD8+ T Cells That Coexpress RORγt and T-bet Are Functionally Impaired and Expand in Patients with Distal Bile Duct Cancer. Journal of Immunology 2017 ;Volum 198.(4) s. 1729-1739
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18 Chu, Dinh Toi; Tao, Yang; Tasken, Kjetil.
OPA1 in Lipid Metabolism: Function of OPA1 in Lipolysis and Thermogenesis of Adipocytes. Hormone and Metabolic Research 2017 ;Volum 49.(4) s. 276-285
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19 Dukic, Aleksandra; Ahmad, Rafi; Tasken, Kjetil.
Targeting the Connexin43-Ezrin interaction. 8th Annual Network Meeting of the Nordic EMBL Partnership for Molecular Medicine; 2017-09-04 - 2017-09-07
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20 Dukic, Aleksandra; Guillaume, Pidoux; Ahmad, Rafi; Tasken, Kjetil.
Targeting the Connexin43-Ezrin interaction. Abstract of the International Gap Junction Conference; 2017-07-29 - 2017-08-02
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21 Dukic, Aleksandra; Haugen, Linda Hofstad; Pidoux, Guillaume; Leithe, Edward; Bakke, Oddmund; Tasken, Kjetil.
A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells. Cellular Signalling 2017 ;Volum 32. s. 1-11
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22 Dukic, Aleksandra; McClymont, David; Tasken, Kjetil.
A Cell-Based High-Throughput Assay for Gap Junction Communication Suitable for Assessing Connexin 43-Ezrin Interaction Disruptors Using IncuCyte ZOOM. Journal of Biomolecular Screening 2017 ;Volum 22.(1) s. 77-85
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23 Evjen, Tove Julie; Dick, Gunnar; Skogli, Erik Winther; Høiseth-Gilje, Kaja; Jakobsen, Kjetill Sigurd; Tasken, Kjetil.
Den digitale bioteknologien i Norge - Muligheter for verdiskaping, kompetansebehov og utfordringer i næringsutvikling. Universitetet i Oslo: Senter for digitalt liv, Norge 2017 (ISBN 978-82-93591-00-9) 60 s.
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24 Gunasekaran, Stalin Chellappa; Hugenschmidt, Harald; Hagness, Morten; Subramani, Saranya; Melum, Espen; Line, Pål Dag; Labori, Knut Jørgen; Wiedswang, Gro; Tasken, Kjetil; Aandahl, Einar Martin.
CD8+ T cells that coexpress ROR?t and T-bet are functionally impaired and expand in patients with distal bile duct cancer. Journal of Immunology 2017 ;Volum 198.(4) s. 1729-1739
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25 Landskron, Johannes; Kraggerud, Sigrid M.; Wik, Elisabeth; Dørum, Anne; Bjørnslett, Merete Pauline; Melum, Espen; Helland, Øystein; Bjørge, Line; Lothe, Ragnhild A; Salvesen, Helga; Tasken, Kjetil.
C77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive disease. PLOS ONE 2017 ;Volum 12:e0182030.(7) s. 1-12
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26 Moltu, Kristine; Henjum, Karen; Oberprieler, Nikolaus; Bjørnbeth, Bjørn Atle; Tasken, Kjetil.
Proximal signaling responses in peripheral T cells from colorectal cancer patients are affected by high concentrations of circulating prostaglandin E2. Human Immunology 2017 ;Volum 78.(2) s. 129-137
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27 Prebensen, Christian; Trøseid, Marius; Ueland, Thor; Dahm, Anders Erik A; Sandset, Per Morten; Aaberge, Ingeborg Sundsvalen; Waalen, Kristian; Dyrhol-Riise, Anne Ma; Tasken, Kjetil; Kvale, Dag.
Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial. PLOS ONE 2017 ;Volum 12.(5) s. -
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28 Taraldsrud, Eli; Fevang, Børre; Jørgensen, Silje Fjellgård; Moltu, Kristine; Hilden, Vera Irene; Tasken, Kjetil; Aukrust, Pål; Myklebust, June; Olweus, Johanna.
Defective IL-4 signaling in T cells defines severe common variable immunodeficiency. Journal of Autoimmunity 2017 ;Volum 81. s. 110-119
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29 Wang, Dong; Fløisand, Yngvar; Myklebust, Camilla Victoria; Bürgler, Simone; Ribes, Anna Maria Parente; Hofgaard, Peter Olaf; Bogen, Bjarne; Tasken, Kjetil; Tjønnfjord, Geir Erland; Schjesvold, Fredrik Hellem; Dalgaard, Jakob; Tveita, Anders; Munthe, Ludvig Andre.
Autologous bone marrow Th cells can support multiple myeloma cell proliferation in vitro and in xenografted mice. Leukemia 2017 ;Volum 31.(10) s. 2114-2121
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2016
30 Aronsen, Jan Magnus; Skogestad, Jonas; Hougen, Karina; Lunde, Marianne; Lothe, Gustav B; Albert, Ingrid; Marshall, Serena; Børstad, Mira Halvorsen; Lunde, Per Kristian; Morth, Jens Preben; Tasken, Kjetil; Carlson, Cathrine Rein; Sjaastad, Ivar.
Physical coupling of PDE3A regulates SERCA2 activity in cardiomyocytes. Innovative Answers to Classic Cardiac Questions, CRS, GRS, 4.-5. juni og Atoms to Omics, New Approaches to Understand and Treat Cardiac Disease, CRS, GRS, 5.-10.juni; 2016-06-04 - 2016-06-10
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31 Bains, Simer Jit; Mahic, Milada; Myklebust, Tor Åge; Småstuen, Milada C; Yaqub, Sheraz; Dørum, Liv Marit; Bjørnbeth, Bjørn Atle; Møller, Bjørn; Brudvik, Kristoffer Watten; Tasken, Kjetil.
Aspirin as secondary prevention in patients with colorectal cancer: An unselected population-based study. Journal of Clinical Oncology 2016 ;Volum 34.(21) s. 2501-2508
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32 Bjerregaard-Andersen, Kaare; Østensen, Ellen; Scott, John D.; Tasken, Kjetil; Morth, Jens Preben.
Malonate in the nucleotide-binding site traps human AKAP18γ/δ in a novel conformational state. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2016 ;Volum 72. s. 591-597
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33 Gunasekaran, Stalin Chellappa; Hugenschmidt, Harald; Hagness, Morten; Line, Pål Dag; Labori, Knut Jørgen; Wiedswang, Gro; Tasken, Kjetil; Aandahl, Einar Martin.
Regulatory T cells that co-express RORγt and FOXP3 are pro-inflammatory and immunosuppressive and expand in human pancreatic cancer. Oncoimmunology 2016 ;Volum 5.(4) s. -
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34 Gunasekaran, Stalin Chellappa; Lieske, Nora Valeska; Hagness, Morten; Line, Pål Dag; Tasken, Kjetil; Aandahl, Einar Martin.
Human regulatory T cells control TCR signaling and susceptibility to suppression in CD4+ T cells. Journal of Leukocyte Biology 2016 ;Volum 100.(1) s. 5-16
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35 Liu, Lisa L.; Landskron, Johannes; Ask, Eivind Heggernes; Enqvist, Monika; Sohlberg, Ebba; Traherne, James A.; Hammer, Quirin; Goodridge, Jodie; Larsson, Stella; Jayaraman, Jyothi; Oei, Vincent Yi Sheng; Schaffer, Marie; Tasken, Kjetil; Ljunggren, Hans-Gustaf; Romagnani, Chiara; Trowsdale, John; Malmberg, Karl-Johan; Béziat, Vivien.
Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans. Cell reports 2016 ;Volum 15.(3) s. 1088-1099
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36 Ribes, Anna Maria Parente; Skånland, Sigrid Strand; Bürgler, Simone; Os, Audun; Wang, Dong; Bogen, Bjarne; Tjønnfjord, Geir Erland; Tasken, Kjetil; Munthe, Ludvig Andre.
Spleen tyrosine kinase inhibitors reduce CD40l-induced proliferation of chronic lymphocytic leukemia cells but not normal B cells. Haematologica 2016 ;Volum 101.(2) s. e59-e62
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37 Stiksrud, Birgitte; Lorvik, Kristina Berg; Kvale, Dag; Mollnes, Tom Eirik; Ueland, Per Magne; Trøseid, Marius; Tasken, Kjetil; Dyrhol-Riise, Anne Ma.
Plasma IP-10 is increased in immunological nonresponders and associated with activated regulatory T cells and persisting low CD4 counts. Journal of Acquired Immune Deficiency Syndromes 2016 ;Volum 73.(2) s. 138-148
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38 Tonby, Kristian; Wergeland, Ida; Lieske, Nora Valeska; Kvale, Dag; Tasken, Kjetil; Dyrhol-Riise, Anne Ma.
The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection. BMC Infectious Diseases 2016 ;Volum 16:599. s. 1-12
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39 Wehbi, Vanessa Leila; Tasken, Kjetil.
Molecular mechanisms for cAMP-mediated immunoregulation in T cells - role of anchored protein kinase a signaling units. Frontiers in Immunology 2016 ;Volum 7:222.
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2015
40 Albert, Ingrid; Børstad, Mira Halvorsen; Carlson, Cathrine Rein; Calejo, Anna; Skogestad, Jonas; Lunde, Marianne; Lunde, Per Kristian; Tasken, Kjetil; Sjaastad, Ivar; Aronsen, Jan Magnus.
Development of SERCA2 activating agents. 13th Annual CHFR Symposium; 2015-09-23 - 2015-09-25
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41 Aronsen, Jan Magnus; Skogestad, Jonas; Hougen, Karina; Lunde, Marianne; Lothe, Gustav B; Albert, Ingrid; Marshall, Serena; Lunde, Per Kristian; Morth, Jens Preben; Tasken, Kjetil; Carlson, Cathrine Rein; Sjaastad, Ivar.
Physical coupling between SERCA2 and PDE3A regulates SERCA2 activity in cardiomyocytes. 13th Annual CHFR Symposium; 2015-09-24 - 2015-09-25
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42 Costa Calejo, Ana Isabel; Tasken, Kjetil.
Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins. Frontiers in Pharmacology 2015 ;Volum 6:192.
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43 Gerbaud, Pascal; Tasken, Kjetil; Pidoux, Guillaume.
Spatiotemporal regulation of cAMP signaling controls the human trophoblast fusion. Frontiers in Pharmacology 2015 ;Volum 6:202.
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44 Johnsen, Guro Mørk; Sheng, Vincent O.Y.; Tasken, Kjetil; Staff, Anne Cathrine; Malmberg, Karl-Johan.
Killer immunoglobulin-like receptors (KIRS) on 3rd trimester decidual natural killer cells. Journal of Reproductive Immunology 2015 ;Volum 111. s. 11-
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45 Landskron, Johannes; Helland, Øystein; Torgersen, Knut Martin; Aandahl, Einar Martin; Gjertsen, Bjørn Tore; Bjørge, Line; Tasken, Kjetil.
Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients. Cancer Immunology and Immunotherapy 2015 ;Volum 64.(3) s. 337-347
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46 Landskron, Johannes; Helland, Øystein; Torgersen, Knut Martin; Aandahl, Einar Martin; Gjertsen, Bjørn Tore; Bjørge, Line; Tasken, Kjetil.
Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients. Cancer Immunology and Immunotherapy 2015 ;Volum 64.(3) s. 337-347
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47 Lieske, Nora Valeska; Tonby, Kristian; Kvale, Dag; Dyrhol-Riise, Anne Ma; Tasken, Kjetil.
Targeting tuberculosis and HIV infection-specific regulatory T cells with MEK/ERK signaling pathway inhibitors. PLOS ONE 2015 ;Volum 10:e0141903.(11) s. -
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48 Pidoux, Guillaume; Tasken, Kjetil.
Anchored PKA as a gatekeeper for gap junctions. Communicative & Integrative Biology 2015 ;Volum 8.(4) s. 1-4
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49 Raslan, Z; Magwenzi, S; Aburima, A; Tasken, Kjetil; Naseem, KM.
Targeting of type I protein kinase A to lipid rafts is required for platelet inhibition by the 3′,5′-cyclic adenosine monophosphate-signaling pathway. Journal of Thrombosis and Haemostasis 2015 ;Volum 13.(9) s. 1721-1734
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50 Santegoets, Saskia J.A.M.; Dijkgraaf, Eveline M.; Battaglia, Alessandra; Beckhove, Philipp; Britten, Cedrik M.; Gallimore, Awen; Godkin, Andrew; Gouttefangeas, Cecile; de Gruijl, Tanja D.; Koenen, Hans J.P.M.; Scheffold, Alexander; Shevach, Ethan M.; Staats, Janet; Tasken, Kjetil; Whiteside, Theresa L.; Kroep, Judith R.; Welters, Marij J.P.; van der Burg, Sjoerd H..
Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry. Cancer Immunology and Immunotherapy 2015 ;Volum 64.(10) s. 1271-1286
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