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2023
1 Casey, Nicholas Paul; Klee, Clara Helena; Bøthun, Anne Fåne; Caulier, Benjamin William; Graczyk-Jarzynka, Agnieszka; Krawczyk, Marta; Fidyt, Klaudyna; Josefsson, Sarah Elisabet; Köksal, Hakan; Dillard, Pierre; Patkowska, Elzbieta; Firczuk, Malgorzata; Smeland, Erlend Bremertun; Winiarska, Magdalena; Myklebust, June Helen; Inderberg, Else Marit; Wälchli, Sébastien.
Efficient chimeric antigen receptor targeting of a central epitope of CD22. Journal of Biological Chemistry 2023 ;Volum 299.(7) s. -
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2 Spasevska, Ivana; Sharma, Ankush; Steen, Chloe Beate; Josefsson, Sarah Elisabet; Blaker, Yngvild Nuvin; Kolstad, Arne; Rustad, Even Holth; Meyer, Saskia; Isaksen, Kathrine Thuestad; Chellappa, Stalin; Kushekhar, Kushi; Beiske, Klaus Hermann; Førsund, Mette S; Spetalen, Signe; Holte, Harald; Østenstad, Bjørn; Brodtkorb, Marianne; Kimby, Eva; Olweus, Johanna; Tasken, Kjetil; Newman, Aron M; Lorenz, Susanne; Smeland, Erlend Bremertun; Alizadeh, Ash A.; Huse, Kanutte; Myklebust, June Helen.
Diversity of intratumoral regulatory T cells in B-cell non-Hodgkin lymphoma. Blood Advances 2023 ;Volum 7.(23) s. 7216-7230
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2022
3 Cui, Xueyan; Myklebust, June Helen; Munthe, Ludvig A.; Schjesvold, Fredrik Hellem; Tjønnfjord, Geir Erland; Sandset, Per Morten; Stavik, Benedicte.
Low expression of coagulation inhibitors in the immune microenvironment in precursor stages of multiple myeloma. Research and Practice in Thrombosis and Haemostasis (RPTH) 2022
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4 Cui, Xueyan; Myklebust, June Helen; Munthe, Ludvig A; Schjesvold, Fredrik Hellem; Tjønnfjord, Geir Erland; Stavik, Benedicte; Sandset, Per Morten.
Single-cell sequencing reveals procoagulant microenvironment in precursor stages of multiple myeloma. Nordic Myeloma Study Group Autumn Meeting; 2022-09-14 - 2022-09-16
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5 Huse, Kanutte; Bai, Baoyan; Hilden, Vera Irene; Bollum, Lise Kristin; Våtsveen, Thea Kristin; Munthe, Ludvig Andre; Smeland, Erlend Bremertun; Irish, Jonathan M.; Wälchli, Sébastien; Myklebust, June Helen.
Mechanism of CD79A and CD79B support for IgM+ B cell fitness through B cell receptor surface expression. Journal of Immunology 2022 ;Volum 209.(10) s. 2042-2053
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2021
6 Köksal, Hakan; Dillard, Pierre; Juzeniene, Asta; Kvalheim, Gunnar; Smeland, Erlend B.; Myklebust, June Helen; Inderberg, Else Marit; Wälchli, Sébastien.
Combinatorial CAR design improves target restriction. Journal of Biological Chemistry 2021 ;Volum 296:100116. s. 1-13
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7 Oksvold, Morten Pedersen; Berglund, Ulrika Warpman; Gad, Helge; Bai, Baoyan; Stokke, Trond; Rein, Idun Dale; Pham, Therese; Sanjiv, Kumar; Øy, Geir Frode; Norum, Jens Henrik; Smeland, Erlend Bremertun; Myklebust, June Helen; Helleday, Thomas; Våtsveen, Thea Kristin.
Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma. Scientific Reports 2021 ;Volum 11.(1) s. -
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8 Rye, Inga Hansine; Huse, Kanutte; Josefsson, Sarah Elisabet; Kildal, Wanja; Danielsen, Håvard Emil Greger; Schlichting, Ellen; Garred, Øystein; Riis, Margit; Lingjærde, Ole Christian; Myklebust, June Helen; Russnes, Hege Elisabeth Giercksky; Sahlberg, Kristine Kleivi; Bathen, Tone Frost; Borgen, Elin; Børresen-Dale, Anne-Lise; Engebråten, Olav; Fritzman, Britt; Geisler, Jürgen; Geitvik, Gry Aarum; Hofvind, Solveig Sand-Hanssen; Kristensen, Vessela N.; Kåresen, Rolf; Langerød, Anita; Mælandsmo, Gunhild Mari; Naume, Bjørn; Sauer, Torill; Skjerven, Helle; Sørlie, Therese.
Breast cancer metastasis: immune profiling of lymph nodes reveals exhaustion of effector T cells and immunosuppression. Molecular Oncology 2021 ;Volum 16.(1) s. 88-103
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9 Spasevska, Ivana; Myklebust, June Helen.
What it takes to transform a T cell. Cancer Research 2021 ;Volum 81.(12) s. 3160-3161
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10 Steen, Chloé Beate; Luca, Bogdan A.; Esfahani, Mohammad S.; Azizi, Armon; Sworder, Brian J.; Nabet, Barzin Y.; Kurtz, David M.; Liu, Chih Long; Khameneh, Farnaz; Advani, Ranjana H.; Natkunam, Yasodha; Myklebust, June Helen; Diehn, Maximilian; Gentles, Andrew J.; Newman, Aaron M.; Alizadeh, Ash A..
The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma. Cancer Cell 2021 ;Volum 39.(10) s. 1422-1437
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2020
11 Bai, Baoyan; Myklebust, June Helen; Wälchli, Sébastien.
Gene editing in B-lymphoma cell lines using CRISPR/Cas9 technology. Methods in molecular biology 2020 ;Volum 2115. s. 445-454
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12 Majzner, Robbie G.; Rietberg, Skyler P.; Sotillo, Elena; Dong, Rui; Vachharajani, Vipul T.; Labanieh, Louai; Myklebust, June Helen; Kadapakkam, Meena; Weber, Evan W.; Tousley, Aidan M.; Richards, Rebecca M.; Heitzeneder, Sabine; Nguyen, Sang M.; Wiebking, Volker; Theruvath, Johanna; Lynn, Rachel C.; Xu, Peng; Dunn, Alexander R.; Vale, Ronald D.; Mackall, Crystal L..
Tuning the antigen density requirement for car T-cell activity. Cancer Discovery 2020 ;Volum 10.(5) s. 702-723
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13 Wise, Jillian; Nakken, Sigve; Steen, Chloe Beate; Vodak, Daniel; Trøen, Gunhild; Johannessen, Bjarne; Lingjærde, Ole Christian; Hilden, Vera Irene; Blaker, Yngvild Nuvin; Bai, Baoyan; Aasheim, Lars Birger; Pasanen, Annika; Lorenz, Susanne; Sveen, Anita; Lothe, Ragnhild A; Myklebost, Ola; Leppä, Sirpa; Meza, Leonardo Zepeda; Beiske, Klaus; Lawrence, Michael S.; Hovig, Eivind; Myklebust, June Helen; Smeland, Erlend B.; Holte, Harald.
Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series. Blood Advances 2020 ;Volum 4.(9) s. 1859-1866
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2019
14 Bai, Baoyan; Vodák, Daniel; Nakken, Sigve; Wise, Jillian; Blaker, Yngvild Nuvin; Lingjærde, Ole Christian; Brodtkorb, Marianne; Hilden, Vera Irene; Trøen, Gunhild; Lorenz, Susanne; Lawrence, Michael S.; Myklebost, Ola; Meza, Leonardo Zepeda; Beiske, Klaus; Hovig, Eivind; Smeland, Erlend B; Holte, Harald; Myklebust, June Helen.
Deep profiling of genetic aberrations and clonal evolution in follicular lymphoma. Blood 2019 ;Volum 134.(1) s. 20-20
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15 Huse, Kanutte; Wogsland, Cara Ellen; Polikowsky, Hannah G.; Diggins, Kirsten E.; Smeland, Erlend B; Myklebust, June; Irish, Jonathan Michael.
Human Germinal Center B Cells Differ from Naive and Memory B Cells in CD40 Expression and CD40L-Induced Signaling Response. Cytometry Part A 2019 ;Volum 95.(4) s. 442-449
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16 Josefsson, Sarah Elisabet; Beiske, Klaus; Blaker, Yngvild Nuvin; Førsund, Mette S; Holte, Harald; Østenstad, Bjørn; Kimby, Eva; Köksal, Hakan; Wälchli, Sébastien; Bai, Baoyan; Smeland, Erlend B; Levy, Ronald; Kolstad, Arne; Huse, Kanutte; Myklebust, June.
TIGIT and PD-1 mark intratumoral T cells with reduced effector function in B-cell non-Hodgkin lymphoma. Cancer immunology research 2019 ;Volum 7.(3) s. 355-362
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17 Köksal, Hakan; Dillard, Pierre; Josefsson, Sarah Elisabet; Maggadottir, Solrun Melkorka; Pollmann, Sylvie Mireille; Fåne, Anne; Blaker, Yngvild Nuvin; Beiske, Klaus; Huse, Kanutte; Kolstad, Arne; Holte, Harald; Kvalheim, Gunnar; Smeland, Erlend B; Myklebust, June Helen; Inderberg, Else Marit; Wälchli, Sébastien.
Preclinical development of CD37CAR T-cell therapy for treatment of B-cell lymphoma. Blood Advances 2019 ;Volum 3.(8) s. 1230-1243
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18 Mensali, Nadia; Dillard, Pierre; Hebeisen, Michael; Lorenz, Susanne; Theodossiou, Theodossis; Myhre, Marit Renee; Fåne, Anne; Gaudernack, Gustav; Kvalheim, Gunnar; Myklebust, June; Inderberg, Else Marit; Wälchli, Sébastien.
NK cells specifically TCR-dressed to kill cancer cells. EBioMedicine 2019 ;Volum 40. s. 106-117
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19 Steen, Chloe Beate; Leich, Ellen; Myklebust, June Helen; Lockmer, Sandra; Wise, Jillian; Wahlin, Björn Engelbrekt; Østenstad, Bjørn; Liestøl, Knut; Kimby, Eva; Rosenwald, Andreas; Smeland, Erlend B; Holte, Harald; Lingjærde, Ole Christian; Brodtkorb, Marianne.
A clinico-molecular predictor identifies follicular lymphoma patients at risk of early transformation after first-line immunotherapy. Haematologica 2019 ;Volum 104.(10) s. 460-464
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2018
20 Holte, Harald; Beiske, Klaus; Boyle, Merrill; Trøen, Gunhild; Blaker, Yngvild Nuvin; Myklebust, June; Kvaløy, Anne Sunniva; Rosenwald, Andreas; Lingjærde, Ole Christian; Rimsza, Lisa M.; Smeland, Erlend B; Scott, David W.; Kolstad, Arne.
The MCL35 gene expression proliferation assay predicts high-risk MCL patients in a Norwegian cohort of younger patients given intensive first line therapy. British Journal of Haematology 2018 s. 1-10
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21 Våtsveen, Thea Kristin; Myhre, Marit Renee; Steen, Chloe Beate; Wälchli, Sébastien; Lingjærde, Ole Christian; Bai, Baoyan; Dillard, Pierre; Theodossiou, Theodossis; Holien, Toril; Sundan, Anders; Inderberg, Else Marit; Smeland, Erlend B; Myklebust, June; Oksvold, Morten Pedersen.
Artesunate shows potent anti-tumor activity in B-cell lymphoma. Journal of Hematology & Oncology 2018 ;Volum 11:23. s. 1-12
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2017
22 Bollum, Lise Kristin; Huse, Kanutte; Oksvold, Morten Pedersen; Bai, Baoyan; Hilden, Vera Irene; Forfang, Lise; Yoon, So; Wälchli, Sébastien; Smeland, Erlend B; Myklebust, June.
BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5. PLOS ONE 2017 ;Volum 12.(5)
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23 Inderberg, Else Marit; Mensali, Nadia; Oksvold, Morten Pedersen; Fallang, Lars Egil; Fåne, Anne; Skorstad, Gjertrud; Stenvik, Grethe-Elisabeth; Progida, Cinzia; Bakke, Oddmund; Kvalheim, Gunnar; Myklebust, June; Wälchli, Sébastien.
Human c-SRC kinase (CSK) overexpression makes T cells dummy. Cancer Immunology and Immunotherapy 2017 ;Volum 67.(4) s. 525-536
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24 Josefsson, Sarah Elisabet Göthberg; Huse, Kanutte; Kolstad, Arne; Beiske, Klaus; Pende, Daniela; Steen, Chloe Beate; Inderberg, Else Marit; Lingjærde, Ole Christian; Østenstad, Bjørn; Smeland, Erlend B; Levy, Ronald; Irish, Jonathan M.; Myklebust, June.
T cells expressing checkpoint receptor TIGIT are enriched in follicular lymphoma tumors and characterized by reversible suppression of T-cell receptor signaling. Clinical Cancer Research 2017 ;Volum 24.(4) s. 870-881
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25 Myklebust, June; Brody, Joshua; Kohrt, Holbrook E.; Kolstad, Arne; Czerwinski, Debra K; Waelchli, Sebastien; Green, Michael R.; Trøen, Gunhild; Liestøl, Knut; Beiske, Klaus; Houot, Roch; Delabie, Jan; Alizadeh, Ash A.; Irish, Jonathan M.; Levy, Ronald.
Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling. Blood 2017 ;Volum 129.(6) s. 759-770
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26 Taraldsrud, Eli; Aukrust, Pål; Jørgensen, Silje Fjellgård; Lingjærde, Ole Christian; Olweus, Johanna; Myklebust, June; Fevang, Børre.
Patterns of constitutively phosphorylated kinases in B cells are associated with disease severity in common variable immunodeficiency. Clinical Immunology 2017 ;Volum 175. s. 69-74
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27 Taraldsrud, Eli; Fevang, Børre; Jørgensen, Silje Fjellgård; Moltu, Kristine; Hilden, Vera Irene; Tasken, Kjetil; Aukrust, Pål; Myklebust, June; Olweus, Johanna.
Defective IL-4 signaling in T cells defines severe common variable immunodeficiency. Journal of Autoimmunity 2017 ;Volum 81. s. 110-119
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28 Wogsland, Cara Ellen; Greenplate, Allison Rae; Kolstad, Arne; Myklebust, June; Irish, Jonathan Michael; Huse, Kanutte.
Mass cytometry of follicular lymphoma tumors reveals intrinsic heterogeneity in proteins including HLA-DR and a deficit in nonmalignant plasmablast and germinal center B-cell populations. Cytometry Part B: Clinical Cytometry 2017 ;Volum 92.(1) s. 79-87
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2016
29 Blaker, Yngvild Nuvin; Spetalen, Signe; Eide, Marianne Brodtkorb; Lingjærde, Ole Christian; Beiske, Klaus; Østenstad, Bjørn; Sander, Birgitta; Wahlin, Björn Engelbrekt; Melen, Christopher Michael; Myklebust, June; Holte, Harald; Delabie, Jan; Smeland, Erlend B.
The tumour microenvironment influences survival and time to transformation in follicular lymphoma in the rituximab era. British Journal of Haematology 2016 ;Volum 175.(1) s. 102-114
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30 Holm, Kristine Lillebø; Indrevær, Randi Larsen; Myklebust, June; Kolstad, Arne; Moskaug, Jan Øivind; Naderi, Elin Hallan; Blomhoff, Heidi Kiil.
Myeloid cell leukaemia 1 has a vital role in retinoic acid-mediated protection of Toll-like receptor 9-stimulated B cells from spontaneous and DNA damage-induced apoptosis. Immunology 2016 ;Volum 149.(1) s. 62-73
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2015
31 Blix, Egil Støre; Kildal, Anders Benjamin; Bertelsen, Eirin Listau; Waage, Anders; Myklebust, June; Kolstad, Arne; Husebekk, Anne.
Content of endothelial progenitor cells in autologous stem cellgrafts predict survival after transplantation for multiplemyeloma. Biology of Blood and Marrow Transplantation 2015 ;Volum 21.(5) s. 840-847
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32 Oksvold, Morten Pedersen; Duyvestyn, Johanna M.; Dagger, Samantha A.; Taylor, Samuel J.; Forfang, Lise; Myklebust, June; Smeland, Erlend B; Langdon, Wallace Y..
The targeting of human and mouse B lymphocytes by dasatinib. Experimental Hematology 2015 ;Volum 43.(5) s. 352-363.e4
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33 Rein, Idun Dale; Stokke, Caroline; Jalal, Marwa; Myklebust, June; Patzke, Sebastian; Stokke, Trond.
New distinct compartments in the G2 phase of the cell cycle defined by the levels of γH2AX.. Cell Cycle 2015 ;Volum 14.(20) s. 3261-3269
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2014
34 Brodtkorb, Marianne; Lingjærde, Ole Christian; Huse, Kanutte; Trøen, Gunhild; Hystad, Marit Elise; Hilden, Vera Irene; Myklebust, June; Leich, Ellen; Rosenwald, Andreas; Delabie, Jan; Holte, Harald; Smeland, Erlend B.
Whole-genome integrative analysis reveals expression signatures predicting transformation in follicular lymphoma. Blood 2014 ;Volum 123.(7) s. 1051-1054
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2013
35 Arita, Adriana; McFarland, Daniel C.; Myklebust, June; Parekh, Samir; Petersen, Bruce; Gabrilove, Janice; Brody, Joshua D..
Signaling pathways in lymphoma: pathogenesis and therapeutic targets. Future Oncology 2013 ;Volum 9.(10) s. 1549-1571
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36 Green, Michael R.; Gentles, Andrew J.; Nair, Ramesh V.; Irish, Jonathan M.; Kihira, Shingo; Liu, Chih Long; Kela, Itai; Hopmans, Erik S.; Myklebust, June; Ji, Hanlee; Plevritis, Sylvia K.; Levy, Ronald; Alizadeh, Ash A..
Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma. Blood 2013 ;Volum 121.(9) s. 1604-1611
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37 Myklebust, June; Irish, Jonathan M.; Brody, Joshua; Czerwinski, Debra K; Houot, Roch; Kohrt, Holbrook E.; Timmerman, John; Said, Jonarhan; Green, Michael R.; Delabie, Jan; Kolstad, Arne; Alizadeh, Ash A.; Levy, Ronald.
High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells. Blood 2013 ;Volum 121.(8) s. 1367-1376
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2012
38 Bakkebø, Maren; Huse, Kanutte; Hilden, Vera Irene; Forfang, Lise; Myklebust, June; Smeland, Erlend B; Oksvold, Morten Pedersen.
SARA is dispensable for functional TGF-beta signaling. FEBS Letters 2012 ;Volum 586.(19) s. 3367-3372
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39 Blix, Egil Støre; Irish, Jonathan M.; Husebekk, Anne; Delabie, Jan; Forfang, Lise; Tierens, Anne; Myklebust, June; Kolstad, Arne.
Phospho-spesific flow cytometry identifies aberrant signaling in indolent B-cell lymphoma. BMC Cancer 2012 ;Volum 12.(478)
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40 Blix, Egil Støre; Irish, Jonathan M.; Husebekk, Anne; Delabie, Jan; Tierens, Anne; Myklebust, June; Kolstad, Arne.
Altered BCR and CD40 signalling are associated with clinical outcome in small lymphocytic lymphoma/chronic lymphocytic leukaemia and marginal zone lymphoma patients. British Journal of Haematology 2012 ;Volum 159.(5) s. 604-608
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41 Huse, Kanutte; Bakkebø, Maren; Waelchli, Sebastien; Oksvold, Morten Pedersen; Hilden, Vera Irene; Forfang, Lise; Bredahl, May K. Lyamouri; Liestøl, Knut; Alizadeh, Ash A.; Smeland, Erlend B; Myklebust, June.
Role of Smad Proteins in Resistance to BMP-Induced Growth Inhibition in B-Cell Lymphoma. PLOS ONE 2012 ;Volum 7.(10) s. -
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2011
42 Alizadeh, Ash A.; Gentles, Andrew J.; Alencar, Alvaro J.; Liu, Chih Long; Kohrt, Holbrook E.; Houot, Roch; Goldstein, Matthew J.; Zhao, Shuchun; Natkunam, Yasodha; Advani, Ranjana H.; Gascoyne, Randy D.; Briones, Javier; Tibshirani, Robert; Myklebust, June; Plevritis, Sylvia K.; Lossos, Izidore S.; Levy, Ronald.
Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment. Blood 2011 ;Volum 118.(5) s. 1350-1358
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43 Huse, Kanutte; Bakkebø, Maren Kolltveit; Oksvold, Morten Pedersen; Forfang, Lise; Hilden, Vera Irene; Stokke, Trond; Smeland, Erlend B; Myklebust, June.
Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: Differential effects of BMP-6 and BMP-7. European Journal of Immunology 2011 ;Volum 41.(11) s. 3135-3145
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44 Tkacz-Stachowska, Kinga Magda; Lund-Andersen, Christin; Velissarou, Angeliki; Myklebust, June; Stokke, Trond; Syljuåsen, Randi G..
The amount of DNA damage needed to activate the radiation-induced G2 checkpoint varies between single cells. Radiotherapy and Oncology 2011 ;Volum 101.(1) s. 24-27
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2010
45 Chao, Mark P.; Alizadeh, AA; Tang, C; Myklebust, June; Varghese, B; Gill, S; Jan, M; Cha, AC; Chan, CK; Tan, BT; Park, CY; Zhao, FF; Kohrt, HE; Malumbres, R; Briones, J; Gascoyne, RD; Lossos, IS; Levy, R; Weissman, IL; Majeti, R.
Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma. Cell 2010 ;Volum 142.(5) s. 699-713
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46 Huse, Kanutte; Bakkebø, Maren; Forfang, Lise; Hilden, Vera Irene; Smeland, Erlend B; Myklebust, June.
Bone Morphogenetic Proteins Inhibit CD40L-and IL-21-Induced Ig Production In Human B Cells: Differential Effects of BMP-6 and BMP-7. Blood 2010 ;Volum 116.(21) s. 729-729
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47 Irish, Jonathan Michael; Myklebust, June; Alizadeh, Ash A.; Houot, Roch; Sharman, Jeff; Czerwinski, Debra K; Nolan, Garry P.; Levy, Ronald.
B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression.. Proceedings of the National Academy of Sciences of the United States of America 2010 ;Volum 127.(29) s. 12747-12754
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48 Myklebust, June; Irish, Jonathan Michael; Brody, Joshua; Alizadeh, Ash A.; Czerwinski, Debra; Houot, Roch; Kohrt, Holbrook E.; Kolstad, Arne; Levy, Ronald.
NF-kappa B Signaling In Response to CpG Stratifies Mantle Cell Lymphoma Patient Outcome. Blood 2010 ;Volum 116.(21) s. 67-68
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2009
49 Gentles, Andrew J.; Alizadeh, Ash A.; Lee, SI; Myklebust, June; Shachaf, CM; Shahbaba, B; Levy, Ronald; Koller, David; Plevritis, Sylvia K..
A pluripotency signature predicts histologic transformation and influences survival in follicular lymphoma patients. Blood 2009 ;Volum 114.(15) s. 3158-3166
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50 Houot, Roch; Goldstein, Matthew J.; Kohrt, Holbrook E.; Myklebust, June; Alizadeh, Ash A.; Lin, Jack T.; Irish, Jonathan M.; Torchia, James A.; Kolstad, Arne; Chen, Lieping; Levy, Ronald.
Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by T-reg depletion. Blood 2009 ;Volum 114.(16) s. 3431-3438
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