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Showing results 1-42 of 42
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2024
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Holmgren, Asbjørn; Akkouh, Ibrahim Ahmed; O'Connell, Kevin Sean; Requena Osete, Jordi; Bjørnstad, Pål Marius; Djurovic, Srdjan; Hughes, Timothy. Bipolar patients display stoichiometric imbalance of gene expression in post-mortem brain samples. Molecular Psychiatry 2024 p. - OUS UiO UiB
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2023
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Akkouh, Ibrahim Ahmed; Ueland, Thor; Szabo, Attila; Hughes, Timothy; Smeland, Olav Bjerkehagen; Andreassen, Ole; Requena Osete, Jordi; Djurovic, Srdjan. Longitudinal Transcriptomic Analysis of Human Cortical Spheroids Identifies Axonal Dysregulation in the Prenatal Brain as a Mediator of Genetic Risk for Schizophrenia. Biological Psychiatry 2023 ;Volume 0. p. 1-12 UiO OUS UiT UiB
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Osete, Jordi Requena; Akkouh, Ibrahim Ahmed; Ievglevskyi, Oleksandr; Vandenberghe, Matthieu; Reis de Assis, Denis; Ueland, Thor; Kondratskaya, Elena; Holen, Børge; Szabo, Attila; Hughes, Timothy; Smeland, Olav Bjerkehagen; Steen, Vidar Martin; Andreassen, Ole; Djurovic, Srdjan. Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids. Molecular Psychiatry 2023 ;Volume 28. p. 3033-3043 UiB UiO OUS
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Requena Osete, Jordi; Akkouh, Ibrahim Ahmed; Ievglevskyi, Oleksandr; Vandenberghe, Matthieu; Reis de Assis, Denis; Ueland, Thor; Kondratskaya, Elena; Holen, Børge; Szabo, Attila; Hughes, Timothy; Smeland, Olav Bjerkehagen; Steen, Vidar Martin; Andreassen, Ole; Djurovic, Srdjan. Characterization of lithium (Li) treated human cortical spheroids (hCS). Molecular Psychiatry 2023 ;Volume 28.(7) p. - OUS UiO UiB
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Torsvik, Anja; Brattbakk, Hans-Richard; Trentani, Andrea; Holdhus, Rita; Stansberg, Christine; Bartz-Johannessen, Christoffer; Hughes, Timothy; Steen, Nils Eiel; Melle, Ingrid; Djurovic, Srdjan; Andreassen, Ole; Steen, Vidar Martin. Patients with schizophrenia and bipolar disorder display a similar global gene expression signature in whole blood that reflects elevated proportion of immature neutrophil cells with association to lipid changes. Translational Psychiatry 2023 ;Volume 13. p. - UiB HAUKELAND UiO OUS
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2022
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6. |
Holmgren, Asbjørn; Hansson, Lars; Bjerkaas-Kjeldal, Kristine; Impellizzeri, Agata Antonina Rita; Gilfillan, Gregor D.; Djurovic, Srdjan; Hughes, Timothy. Mapping the expression of an ANK3 isoform associated with bipolar disorder in the human brain. Translational Psychiatry 2022 ;Volume 12.(45) p. - OUS UiO UiB
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2021
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7. |
Akkouh, Ibrahim; Hughes, Timothy; Steen, Vidar Martin; Glover, Joel; Andreassen, Ole Andreas; Djurovic, Srdjan; Szabo, Attila. Transcriptome analysis reveals disparate expression of inflammation-related miRNAs and their gene targets in iPSC-astrocytes from people with schizophrenia. Brain, Behavior, and Immunity 2021 OUS UiB UiO
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Krull, Florian; Akkouh, Ibrahim Ahmed; Hughes, Timothy; Bettella, Francesco; Athanasiu, Lavinia; Smeland, Olav Bjerkehagen; O'Connell, Kevin Sean; Brattbakk, Hans-Richard; Steen, Vidar Martin; Steen, Nils Eiel; Djurovic, Srdjan; Andreassen, Ole. Dose-dependent transcriptional effects of lithium and adverse effect burden in a psychiatric cohort. Progress in Neuro-psychopharmacology and Biological Psychiatry 2021 ;Volume 112. p. - OUS UiO UiB
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O'Connell, Kevin S.; Sønderby, Ida Elken; Frei, Oleksandr; van der Meer, Dennis; Athanasiu, Lavinia; Smeland, Olav Bjerkehagen; Alnæs, Dag; Kaufmann, Tobias; Westlye, Lars Tjelta; Steen, Vidar Martin; Andreassen, Ole Andreas; Hughes, Timothy; Djurovic, Srdjan. Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank. Psychological Medicine 2021 p. 1-11 UiO OUS UiB HAUKELAND
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Osete, Jordi Requena; Akkouh, Ibrahim; Reis de Assis, Denis; Szabo, Attila; Frei, Evgeniia; Hughes, Timothy; Smeland, Olav Bjerkehagen; Steen, Nils Eiel; Andreassen, Ole Andreas; Djurovic, Srdjan. Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders. Molecular Psychiatry 2021 UiO UiB OUS
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Reis de Assis, Denis; Szabo, Attila; Osete, Jordi Requena; Puppo, Francesca; O'Connell, Kevin S.; Akkouh, Ibrahim; Hughes, Timothy; Frei, Evgeniia; Andreassen, Ole Andreas; Djurovic, Srdjan. Using iPSC Models to Understand the Role of Estrogen in Neuron–Glia Interactions in Schizophrenia and Bipolar Disorder. Cells 2021 ;Volume 10.(2) p. - OUS UiO UiB
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Szabo, Attila; Akkouh, Ibrahim A.; Vandenberghe, Matthieu; Osete, Jordi Requena; Hughes, Timothy; Heine, Vivi; Smeland, Olav B.; Glover, Joel C.; Andreassen, Ole A.; Djurovic, Srdjan. A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia. Translational Psychiatry 2021 ;Volume 11.(1) p. - UiO OUS UiB
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2020
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13. |
Akkouh, Ibrahim; Ueland, Thor; Hansson, Lars; Inderhaug, Elin; Hughes, Timothy; Steen, Nils Eiel; Aukrust, Pål; Andreassen, Ole Andreas; Szabo, Attila; Djurovic, Srdjan. Decreased IL-1β-induced CCL20 response in human iPSC-astrocytes in schizophrenia: Potential attenuating effects on recruitment of regulatory T cells. Brain, Behavior, and Immunity 2020 ;Volume 87. p. 634-644 UiB UiO UiT OUS
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14. |
Hughes, Timothy; Hansson, Lars Johan Axel; Akkouh, Ibrahim; Hajdarevic, Riad; Bringsli, Jorunn; Torsvik, Anja; Inderhaug, Elin; Steen, Vidar Martin; Djurovic, Srdjan. Runaway multi-allelic copy number variation at the α-defensin locus in African and Asian populations. Scientific Reports 2020 ;Volume 10.(9101) p. 1-8 UiO OUS UiB HAUKELAND
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2019
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15. |
Akkouh, Ibrahim; Skrede, Silje; Holmgren, Asbjørn; Ersland, Kari Merete; Hansson, Lars Johan Axel; Bahrami, Shahram; Andreassen, Ole Andreas; Steen, Vidar Martin; Djurovic, Srdjan; Hughes, Timothy. Exploring lithium's transcriptional mechanisms of action in bipolar disorder: a multi-step study. Neuropsychopharmacology 2019 p. 1-9 UiO OUS UiB HAUKELAND
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2018
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16. |
Akkouh, Ibrahim; Ueland, Torill; Andreassen, Ole Andreas; Brattbakk, Hans-Richard; Steen, Vidar Martin; Hughes, Timothy; Djurovic, Srdjan. Expression of TCN1 in Blood is Negatively Associated with Verbal Declarative Memory Performance. Scientific Reports 2018 ;Volume 8:12654. p. 1-11 UiO OUS UiB HAUKELAND
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17. |
Hughes, Timothy; Sønderby, Ida Elken; Polushina, Tatiana; Hansson, Lars Johan Axel; Holmgren, Asbjørn; Athanasiu, Lavinia; Melbø-Jørgensen, Christian; Hassani, Sahar; Hoeffding, Louise K.; Herms, Stefan; Bergen, Sarah E.; Karlsson, Robert; Song, Jie; Rietschel, Marcella; Nöthen, Markus M.; Forstner, Andreas J.; Hoffmann, Per; Hultman, Christina M.; Landén, Mikael; Cichon, Sven; Werge, Thomas; Andreassen, Ole Andreas; Le Hellard, Stephanie; Djurovic, Srdjan. Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder. Translational Psychiatry 2018 ;Volume 8.(210) p. 1-10 UiO OUS UiB HAUKELAND
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18. |
Segorbe, David; Wilkinson, Derek; Mizeranschi, Alexandru; Hughes, Timothy; Aaløkken, Ragnhild; Váchová, Libuše; Palková, Zdena; Gilfillan, Gregor Duncan. An optimized FAIRE procedure for low cell numbers in yeast. Yeast 2018 ;Volume 35.(8) p. 507-512 UiO OUS
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19. |
Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas; White, Linda Rosemary; Selbæk, Geir; Stordal, Eystein; Andersen, Fred; Brækhus, Anne; Saltvedt, Ingvild; Engedal, Knut; Hughes, Timothy; Bergh, Sverre; Bråthen, Geir; Bogdanovic, Nenad; Bettella, Francesco; Wang, Yunpeng; Athanasiu, Lavinia; Bahrami, Shahram; Le Hellard, Stephanie; Giddaluru, Sudheer; Dale, Anders M; Sando, Sigrid Botne; Steinberg, Stacy; Stefansson, Hreinn; Snaedal, Jon; Desikan, Rahul S; Stefansson, Kari; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Andreassen, Ole Andreas. Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci. Scientific Reports 2018 ;Volume 8. p. - UiO UiB UiT NTNU AHUS SUS OUS SI HELSEFONNA STO HAUKELAND SIV
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2017
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20. |
Maršíková, Jana; Wilkinson, Derek; Hlaváček, Otakar; Gilfillan, Gregor Duncan; Mizeranschi, Alexandru; Hughes, Timothy; Begany, Markéta; Rešetárová, Stanislava; Váchová, Libuše; Palková, Zdena. Metabolic differentiation of surface and invasive cells of yeast colony biofilms revealed by gene expression profiling. BMC Genomics 2017 ;Volume 18:814. p. 1-16 UiO OUS
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21. |
Rasmussen, Henrik Berg; Madsen, Majbritt Busk; Lyauk, Yassine Kamal; Hansen, Peter Riis; Hughes, Timothy. Carboxylesterase 1A2 encoding gene with increased transcription and potential rapid drug metabolism in Asian populations. Drug Metabolism and Personalized Therapy 2017 ;Volume 32.(3) p. 163-168 OUS
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2016
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Barøy, Tuva; Pedurupillay Jesuthasan, Christeen Ramane; Bliksrud, Yngve Thomas; Rasmussen, Magnhild; Holmgren, Asbjørn; Vigeland, Magnus Dehli; Hughes, Timothy; Brink, Maaike; Rodenburg, Richard J.; Nedregaard, Bård; Strømme, Petter; Frengen, Eirik; Misceo, Doriana. A novel mutation in FBXL4 in a Norwegian child with encephalomyopathic mitochondrial DNA depletion syndrome 13. European Journal of Medical Genetics 2016 ;Volume 59.(6-7) p. 342-346 UiO OUS
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23. |
Sundaram, Arvind; Hughes, Timothy; Biondi, Shea; Bolduc, Nathalie; Bowman, Sarah K; Camilli, Andrew; Chew, Yap C; Couture, Catherine; Farmer, Andrew; Jerome, John P; Lazinski, David W; McUsic, Andrew; Peng, Xu; Shazand, Kamran; Xu, Feng; Lyle, Robert; Gilfillan, Gregor Duncan. A comparative study of ChIP-seq sequencing library preparation methods. BMC Genomics 2016 ;Volume 17.(1) OUS UiO
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24. |
Tesli, Martin Steen; Wirgenes, Katrine Verena; Hughes, Timothy; Bettella, Francesco; Athanasiu, Lavinia; Hoseth, Eva Zsuzsanna; Nerhus, Mari; Lagerberg, Trine Vik; Steen, Nils Eiel; Agartz, Ingrid; Melle, Ingrid; Dieset, Ingrid; Djurovic, Srdjan; Andreassen, Ole Andreas. VRK2 gene expression in schizophrenia, bipolar disorder and healthy controls. British Journal of Psychiatry 2016 ;Volume 209.(2) p. 114-120 UiO UiB OUS DIAKON VV
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2015
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25. |
Barøy, Tuva; Koster, Janet; Strømme, Petter; Ebberink, Merel S.; Misceo, Doriana; Ferdinandusse, Sacha; Holmgren, Asbjørn; Hughes, Timothy; Merckoll, Else; Westvik, Jostein; Woldseth, Berit; Walter, John; Wood, Nick; Tvedt, Bjørn; Stadskleiv, Kristine; Wanders, Ronald J.A.; Waterham, Hans R.; Frengen, Eirik. A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform. Human Molecular Genetics 2015 ;Volume 24.(20) p. 5845-5854 UiO OUS
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26. |
Hughes, Timothy; Hansson, Lars Johan Axel; Sønderby, Ida Elken; Athanasiu, Lavinia; Zuber, Verena; Tesli, Martin Steen; Song, J; Hultman, Christina M.; Bergen, SE; Landen, M.; Melle, Ingrid; Andreassen, Ole Andreas; Djurovic, Srdjan. A Loss-of-Function Variant in a Minor Isoform of ANK3 Protects Against Bipolar Disorder and Schizophrenia. Biological Psychiatry 2015 UiO UiB OUS
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27. |
Rasmussen, Henrik Berg; Bjerre, Ditte; Linnet, Kristian; Jürgens, Gesche; Dalhoff, Kim; Stefansson, Hreinn; Hankemeier, Thomas; Kaddurah-Daouk, Rima; Taboureau, Olivier; Brunak, Søren; Houmann, Tine; Jeppesen, Pia; Pagsberg, Anne Katrine; Plessen, Kerstin J.; Dyrborg, Jørgen; Hansen, Peter Riis; Hansen, Poul Erik; Hughes, Timothy; Werge, Thomas. Individualization of treatments with drugs metabolized by CES1: Combining genetics and metabolomics. Pharmacogenomics (London) 2015 ;Volume 16.(6) p. 649-665 OUS
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2014
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Wirgenes, Katrine Verena; Tesli, Martin Steen; Inderhaug, Elin; Athanasiu, Lavinia; Agartz, Ingrid; Melle, Ingrid; Hughes, Timothy; Andreassen, Ole Andreas; Djurovic, Srdjan. ANK3 gene expression in bipolar disorder and schizophrenia. British Journal of Psychiatry 2014 ;Volume 205.(3) p. 244-245 UiO OUS DIAKON
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2013
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Baccarani, Michele; Deininger, MW; Rosti, Gianantonio; Hochhaus, Andreas; Soverini, Simona; Apperley, J.F.; Cervantes, Francisco Javier; Clark, RE; Cortes, JE; Guilhot, F; Hjort-Hansen, Henrik; Hughes, Timothy; Kantarjian, HM; Kim, DW; Larson, RA; Lipton, JH; Mahon, François-Xavier; Martinelli, Giovanni; Mayer, Jiri; Müller, Martin C.; Niederwieser, Dietger; Pane, Fabrizio; Radich, JP; Rousselot, P; Saglio, Giuseppe; Saussele, S; Schiffer, C; Silver, R; Simonsson, Bengt; Steegmann, JL; Goldman, JM; Hehlmann, R. European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013. Blood 2013 ;Volume 122.(6) p. 872-884 NTNU STO
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2012
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Eike, Morten Christoph; Lærum, Hallvard; Hughes, Timothy; Bremer, Sara; Bergan, Stein; Thomassen, Gard O Sundby; Aanestad, Margunn; Grünfeld, Thomas; Undlien, Dag Erik. A national platform for clinical genetic analysis of high-throughput sequencing data in Norway. American Society of Human Genetics annual meeting 2012; 2012-11-06 - 2012-11-10 OUS UiO
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31. |
Eike, Morten Christoph; Lærum, Hallvard; Hughes, Timothy; Håndstad, Tony; Bremer, Sara; Bergan, Stein; Thomassen, Gard O Sundby; Aanestad, Margunn; Grünfeld, Thomas; Undlien, Dag Erik. GenAP: a platform for clinical genetic analysis of high-throughput sequencing data. Fagmøte i Medisinsk Genetikk 2012 - Personalised medicine: Integrating genomics into general health care; 2012-11-28 - 2012-11-29 NTNU OUS UiO
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32. |
Gilfillan, Gregor Duncan; Hughes, Timothy; Sheng, Ying; Hjorthaug, Hanne Sagsveen; Straub, Tobias; Gervin, Kristina; Harris, Jennifer; Undlien, Dag Erik; Lyle, Robert. Limitations and possibilities of low cell number ChIP-seq. BMC Genomics 2012 ;Volume 13. p. - OUS UiO FHI
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33. |
Hamfjord, Julian; Stangeland, Astrid Marie; Hughes, Timothy; Skrede, Martina; Tveit, Magne Kjell; Andersen, Tone Ikdahl; Kure, Elin H.. Differential Expression of miRNAs in Colorectal Cancer: Comparison of Paired Tumor Tissue and Adjacent Normal Mucosa Using High-Throughput Sequencing. PLOS ONE 2012 ;Volume 7.(4) p. - OUS USN UiO
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Selmer, Kaja Kristine; Gilfillan, Gregor Duncan; Strømme, Petter; Lyle, Robert; Hughes, Timothy; Hjorthaug, Hanne Sagsveen; Brandal, Kristin; Nakken, Sigve; Misceo, Doriana; Egeland, Thore; Munthe, Ludvig Andre; Brækken, Sigrun Kierulf; Undlien, Dag Erik. A mild form of Mucopolysaccharidosis IIIB diagnosed with targeted next-generation sequencing of linked genomic regions. European Journal of Human Genetics 2012 ;Volume 20.(1) p. 58-63 NMBU UiO OUS
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2010
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Gould, Cathryn M.; Diella, Francesca; Via, Allegra; Puntervoll, Pål; Gemünd, Christine; Chabanis-Davidson, Sophie; Michael, Sushama; Sayadi, Ahmed; Bryne, Jan Christian; Chica, Claudia; Seiler, Markus; Davey, Norman E.; Haslam, Neill; Weatheritt, Robert J.; Budd, Aidan; Hughes, Timothy; Pas, Jakub; Rychlewski, Leszek; Trave, Gilles Michel; Aasland, Rein; Helmer-Citterich, Manuela; Linding, Rune; Gibson, Toby J.. ELM: the status of the 2010 eukaryotic linear motif resource. Nucleic Acids Research (NAR) 2010 ;Volume 38. Suppl. 1 p. D167-D180 UiB NORCE
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2008
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Hughes, Timothy. Computational analysis of the evolutionary dynamics of proteins on a genomic scale. Universitetet i Bergen 2008 UiB
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Hughes, Timothy; Liberles, David A. The power-law distribution of gene family size is driven by the pseudogenisation rate's heterogeneity between gene families. Gene 2008 ;Volume 414.(1-2) p. 85-94 NORCE
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38. |
Hughes, Timothy; Liberles, David A. Whole-genome duplications in the ancestral vertebrate are detectable in the distribution of gene family sizes of tetrapod species. Journal of Molecular Evolution 2008 ;Volume 67.(4) p. 343-357 NORCE
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2007
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Hughes, Timothy. Eukaryotic membranes and cytoskeleton. Springer Science+Business Media B.V. 2007 (ISBN 978-0-387-74020-1) 145 p. NORCE
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40. |
Hughes, Timothy; Ekman, Daniel; Ardawatia, Himanshu; Elofsson, Arne; Liberles, David A. Evaluating dosage compensation as a cause of duplicate gene retention in Paramecium tetraurelia. Genome Biology 2007 ;Volume 8.(8) p. - NORCE
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41. |
Hughes, Timothy; Liberles, David A. The pattern of evolution of smaller-scale gene duplicates in mammalian genomes is more consistent with neo-than subfunctionalisation. Journal of Molecular Evolution 2007 ;Volume 65.(5) p. 574-588 NORCE
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2004
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Hughes, Timothy; Hyun, Y; Liberles, David A. Visualising very large phylogenetic trees in three dimensional hyperbolic space. BMC Bioinformatics 2004 ;Volume 5. p. art. no.-48 UiB
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