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2018
1 Alexeeva, Marina; Guragain, Prashanna; Tesfahun, Almaz Nigatu; Tomkuvienė, Miglė; Arshad, Aysha; Gerasimaitė, Rūta; Rukšėnaitė, Audronė; Urbanavičiūtė, Giedrė; Bjørås, Magnar; Lærdahl, Jon Kristen; Klungland, Arne; Klimašauskas, Saulius; Bjelland, Svein.
Excision of the doubly methylated base N4,5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins. Philosophical Transactions of the Royal Society of London. Biological Sciences 2018 ;Volume 373.(1748)
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2017
2 Strøm, Thea Bismo; Lærdahl, Jon Kristen; Leren, Trond Paul.
Mutations affecting the transmembrane domain of the LDL receptor: Impact of charged residues on the membrane insertion. Human Molecular Genetics 2017 ;Volume 26.(9) p. 1634-1642
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3 Søberg, Kristoffer; Moen, Line Victoria; Skålhegg, Bjørn Steen; Lærdahl, Jon Kristen.
Evolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms. PLoS ONE 2017 ;Volume 12.(7) p. -
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2016
4 Moen, Marivi Nabong; Fjær, Roar; Hamdani, El Hassan; Lærdahl, Jon Kristen; Menchini, Robin Johansen; Vigeland, Magnus Dehli; Sheng, Ying; Undlien, Dag Erik; Hassel, Bjørnar; Salih, MA; Khashab, HY; Selmer, Kaja Kristine; Chaudhry, Farrukh Abbas.
Pathogenic variants in KCTD7 perturb neuronal K+ fluxes and glutamine transport. Brain 2016 ;Volume 139. p. 3109-3120
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2015
5 Dalhus, Bjørn; Backe, Paul Hoff; Lærdahl, Jon Kristen; Rowe, Alexander D.; Blicher, Pernille; Forstrøm, Rune Johansen; Rognes, Torbjørn; Bjørås, Magnar.
Helse Sør-Øst Core Facility for Structural Biology and Bioinformatics. Norsk Biokjemisk Selskap Kontaktmøte 2015; 2015-02-13 - 2015-02-17
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6 Strøm, Thea Bismo; Lærdahl, Jon Kristen; Leren, Trond Paul.
Mutation p.L799R in the LDLR, which affects the transmembrane domain of the LDLR, prevents membrane insertion and causes secretion of the mutant LDLR. Human Molecular Genetics 2015 ;Volume 24.(20) p. 5836-5844
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7 Zeissig, Sebastian; Petersen, Britt-Sabina; Tomczak, Michal; Melum, Espen; Huc-Claustre, Emilie; Dougan, Stephanie K.; Lærdahl, Jon Kristen; Stade, Björn; Forster, Michael; Schreiber, Stefan; Weir, Dascha; Leichtner, Alan M.; Franke, Andre; Blumberg, Richard S..
Early-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4. Gut 2015 ;Volume 64.(12) p. 1889-1897
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2014
8 Andersen, Pernille Strøm; Backe, Paul Hoff; Lærdahl, Jon Kristen; Rowe, Alexander; Forstrøm, Rune Johansen; Rognes, Torbjørn; Bjørås, Magnar; Dalhus, Bjørn.
Helse Sør-Øst Core Facility for Structural Biology and Bioinformatics. NBS Contact meeting 2014; 2014-02-23 - 2014-02-26
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9 Strøm, Thea Bismo; Tveten, Kristian; Lærdahl, Jon Kristen; Leren, Trond Paul.
Mutation G805R in the transmembrane domain of the LDL receptor gene causes familial hypercholesterolemia by inducing ectodomain cleavage of the LDL receptor in the endoplasmic reticulum. FEBS Open Bio 2014 ;Volume 4. p. 321-327
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10 Zegeye, Ephrem Debebe; Balasingham, Seetha; Lærdahl, Jon Kristen; Homberset, Håvard; Kristiansen, Per Eugen; Tønjum, Tone.
Effects of conserved residues and naturally occurring mutations on Mycobacterium tuberculosis RecG helicase activity. Microbiology 2014 ;Volume 160.(1) p. 217-227
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2013
11 Backe, Paul Hoff; Simm, Roger; Lærdahl, Jon Kristen; Dalhus, Bjørn; Fagerlund, Annette; Økstad, Ole Andreas Løchen; Rognes, Torbjørn; Alseth, Ingrun; Kolstø, Anne-Brit; Bjørås, Magnar.
A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures. Journal of Structural Biology 2013 ;Volume 183.(1) p. 66-75
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12 Balasingham, Seetha; Zegeye, Ephrem Debebe; Homberset, Håvard; Rossi, Marie; Lærdahl, Jon Kristen; Bohr, Vilhelm A.; Tønjum, Tone.
Unique Features of DNA Helicases in Mycobacterium tuberculosis. EMBO Conference: Helicases and Nucleic Acid Translocases; 2013-08-04 - 2013-08-08
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13 Balasingham, Seetha; Zegeye, Ephrem Debebe; Homberset, Håvard; Rossi, Marie; Lærdahl, Jon Kristen; Bohr, Vilhelm A.; Tønjum, Tone.
Unique features of DNA repair helicases in Mycobacterium tuberculosis. GMM4: 4th Microbial Genome Maintenance Meeting; 2013-04-26 - 2013-04-29
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14 Ellinghaus, David; Folseraas, Trine; Holm, Kristian; Ellinghaus, Eva; Melum, Espen; Balschun, Tobias; Lærdahl, Jon Kristen; Shiryaev, Alexey; Gotthardt, Daniel; Weismüller, Tobias J.; Schramm, Christoph; Wittig, Michael; Bergquist, Annika; Björnsson, Einar; Marschall, Hanns-Ulrich; Vatn, Morten H; Teufel, Andreas; Rust, Christian; Gieger, Christian; Wichmann, H.-Erich; Runz, Heiko; Sterneck, Martina; Rupp, Christian; Braun, Felix; Weersma, Rinse K.; Wijmenga, Cisca; Ponsioen, Cyriel Y.; Mathew, Christopher G.; Rutgeerts, Paul; Vermeire, Severine; Schrumpf, Erik; Hov, Johannes Espolin Roksund; Manns, Michael P.; Boberg, Kirsten Muri; Schreiber, Stefan; Franke, Andre; Karlsen, Tom Hemming.
Genome-wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4. Hepatology 2013 ;Volume 58.(3) p. 1074-1083
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15 Krokeide, Silje Zandstra; Lærdahl, Jon Kristen; Salah, Medya; Luna, Luisa; Cederkvist, Fritjof Henning; Fleming, Aaron M.; Burrows, Cynthia J.; Dalhus, Bjørn; Bjørås, Magnar.
Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin. DNA Repair 2013 ;Volume 12.(12) p. 1159-1164
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16 Lærdahl, Jon Kristen; Nygård, Ståle; Jonassen, Inge; Hovig, Johannes Eivind; Petersen, Kjell; Drabløs, Finn; Willassen, Nils Peder; Våge, Dag Inge.
The national technology platform for bioinformatics. NBS - Contact Meeting 2013; 2013-01-31 - 2013-02-03
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17 Søberg, Kristoffer; Jahnsen, Tore; Rognes, Torbjørn; Skålhegg, Bjørn Steen; Lærdahl, Jon Kristen.
Evolutionary Paths of the cAMP-Dependent Protein Kinase (PKA) Catalytic Subunits. PLoS ONE 2013 ;Volume 8.(4) p. -
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18 Zegeye, Ephrem Debebe; Balasingham, Seetha; Lærdahl, Jon Kristen; Homberset, Håvard; Tønjum, Tone.
Mycobacterium tuberculosis RecG is a helicase enzyme with broad DNA substrate specificity. EMBO Conference: Helicases and Nucleic Acid Translocases; 2013-08-04 - 2013-08-08
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19 Zegeye, Ephrem Debebe; Balasingham, Seetha; Lærdahl, Jon Kristen; Homberset, Håvard; Tønjum, Tone.
Mycobacterium tuberculosis RecG is a helicase enzyme with broad DNA substrate specificity. GMM4: 4th Microbial Genome Maintenance Meeting; 2013-04-26 - 2013-04-29
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2012
20 Balasingham, Seetha; Zegeye, Ephrem Debebe; Homberset, Håvard; Rossi, Marie; Lærdahl, Jon Kristen; Bohr, Vilhelm A.; Tønjum, Tone.
Enzymatic Activities and DNA Substrate Specificity of Mycobacterium tuberculosis DNA Helicase XPB. PLoS ONE 2012 ;Volume 7.(5) p. -
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21 Balasingham, Seetha; Zegeye, Ephrem Debebe; Nilsen, Mariann; Homberset, Håvard; Rossie, Marie; Lærdahl, Jon Kristen; Bohr, Vilhelm A.; Tønjum, Tone.
Delineating the functions of DNA repair helicases in Mycobacterium tuberculosis. Genome Dynamics in Neuroscience (GDN4)-Genome instability in aging and brain disease.; 2012-09-19 - 2012-09-22
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22 Fladeby, Cathrine; Vik, Erik Sebastian; Lærdahl, Jon Kristen; Neurauter, Christine Gran; Heggelund, Julie Elisabeth; Thorgaard, Eirik; Andersen, Pernille Strøm; Bjørås, Magnar; Dalhus, Bjørn; Alseth, Ingrun.
The Human Homolog of Escherichia coli Endonuclease V Is a Nucleolar Protein with Affinity for Branched DNA Structures. PLoS ONE 2012 ;Volume 7.(11) p. -
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23 Folseraas, Trine; Melum, Espen; Rausch, Philipp; Juran, Brian D.; Ellinghaus, Eva; Shiryaev, Alexey; Lærdahl, Jon Kristen; Ellinghaus, David; Schramm, Christoph; Weismüller, Tobias J.; Gotthard, Daniel Nils; Hov, Johannes Espolin Roksund; Clausen, Ole Petter Fraas; Weersma, Rinse K.; Janse, Marcel; Boberg, Kirsten Muri; Björnsson, Einar; Marschall, Hanns-Ulrich; Cleynen, Isabelle; Rosenstiel, Philip; Holm, Kristian; Teufel, Andreas; Rust, Christian; Gieger, Christian; Wichmann, H.-Erich; Bergquist, Annika; Ryu, Euijung; Ponsioen, Cyriel Y.; Runz, Heiko; Sterneck, Martina; Vermeire, Severine; Beuers, Ulrich; Wijmenga, Cisca; Schrumpf, Erik; Manns, Michael P.; Lazaridis, Konstantinos N.; Schreiber, Stefan; Baines, John F.; Franke, Andre; Karlsen, Tom Hemming.
Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci. Journal of Hepatology 2012 ;Volume 57.(2) p. 366-375
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24 Korvald, Hanne; Falnes, Pål; Lærdahl, Jon Kristen; Bjørås, Magnar; Alseth, Ingrun.
The Schizosaccharomyces pombe AlkB homolog Abh1 exhibits AP lyase activity but no demethylase activity. DNA Repair 2012 ;Volume 11.(5) p. 453-462
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25 Søberg, Kristoffer; Larsen, Anja C V; Diskar, Mandy; Backe, Paul Hoff; Bjørås, Magnar; Jahnsen, Tore; Lærdahl, Jon Kristen; Rognes, Torbjørn; Herberg, Friedrich W.; Skålhegg, Bjørn Steen.
Identification and Characterization of Novel Mutations in the Human Gene Encoding the Catalytic Subunit Calpha of Protein Kinase A (PKA). PLoS ONE 2012 ;Volume 7.(4) p. -
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26 Tveten, Kristian; Holla, Øystein Lunde; Cameron, Jamie; Strøm, Thea Bismo; Berge, Knut Erik; Lærdahl, Jon Kristen; Leren, Trond Paul.
Interaction between the ligand-binding domain of the LDL receptor and the C-terminal domain of PCSK9 is required for PCSK9 to remain bound to the LDL receptor during endosomal acidification. Human Molecular Genetics 2012 ;Volume 21.(6) p. 1402-1409
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27 Zegeye, Ephrem Debebe; Balasingham, Seetha; Lærdahl, Jon Kristen; Homberset, Håvard; Tønjum, Tone.
Mycobacterium tuberculosis RecG binds and unwinds model DNA substrates with a preference for Holliday junctions. Microbiology 2012 ;Volume 158.(Pt 8) p. 1982-1993
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28 Zegeye, Ephrem Debebe; Balasingham, Seetha; Lærdahl, Jon Kristen; Homberset, Håvard; Tønjum, Tone.
Mycobacterium tuberculosis RecG is a helicase enzyme with diverse DNA substrate affinities. EMBO Tuberculosis 2012: Biology, pathogenesis, intervention strategies.; 2012-09-11 - 2012-09-15
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29 Zegeye, Ephrem Debebe; Balasingham, Seetha; Lærdahl, Jon Kristen; Homberset, Håvard; Tønjum, Tone.
Mycobacterium tuberculosis RecG is a helicase enzyme with diverse DNA substrate affinities. Genome Dynamics in Neuroscience (GDN4)-Genome instability in aging and brain disease; 2012-09-19 - 2012-09-22
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2011
30 Holla, Øystein Lunde; Cameron, Jamie; Tveten, Kristian; Strøm, Thea Bismo; Berge, Knut Erik; Lærdahl, Jon Kristen; Leren, Trond Paul.
Role of the C-terminal domain of PCSK9 in degradation of the LDL receptors. Journal of Lipid Research 2011 ;Volume 52.(10) p. 1787-1794
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31 Holla, Øystein Lunde; Lærdahl, Jon Kristen; Strøm, Thea Bismo; Tveten, Kristian; Cameron, Jamie; Berge, Knut Erik; Leren, Trond Paul.
Removal of acidic residues of the prodomain of PCSK9 increases its activity towards the LDL receptor. Biochemical and Biophysical Research Communications - BBRC 2011 ;Volume 406.(2) p. 234-238
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32 Korvald, Hanne; Moe, Anne Margrethe Mølstad; Cederkvist, Fritjof Henning; Thiede, Bernd; Lærdahl, Jon Kristen; Bjørås, Magnar; Alseth, Ingrun.
Schizosaccharomyces pombe Ofd2 Is a Nuclear 2-Oxoglutarate and Iron Dependent Dioxygenase Interacting with Histones. PLoS ONE 2011 ;Volume 6.(9) p. -
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33 Lærdahl, Jon Kristen; Korvald, Hanne; Nilsen, Line; Dahl-Michelsen, Kristin; Rognes, Torbjørn; Bjørås, Magnar; Alseth, Ingrun.
Schizosaccharomyces pombe encodes a mutated AP endonuclease 1. DNA Repair 2011 ;Volume 10.(3) p. 296-305
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34 Melum, Espen; Franke, Andre; Schramm, Christoph; Weismüller, Tobias J.; Gotthardt, Daniel; Offner, Felix A.; Juran, Brian D.; Lærdahl, Jon Kristen; Labi, Verena; Björnsson, Einar; Weersma, Rinse K.; Henckaerts, Liesbet; Teufel, Andreas; Rust, Christian; Ellinghaus, Eva; Balschun, Tobias; Boberg, Kirsten Muri; Ellinghaus, David; Bergquist, Annika; Sauer, Peter E.; Ryu, Euijung; Hov, Johannes Espolin Roksund; Wedemeyer, Jochen; Lindkvist, Björn; Wittig, Michael; Porte, Robert J.; Holm, Kristian; Gieger, Christian; Wichmann, Heinz-Erich; Stokkers, Pieter C.F.; Ponsioen, Cyriel Y.; Runz, Heiko; Stiehl, Adolf; Wijmenga, Cisca; Sterneck, Martina; Vermeire, Severine; Beuers, Ulrich; Villunger, Andreas; Schrumpf, Erik; Lazaridis, Konstantios N; Manns, Michael P.; Schreiber, Stefan; Karlsen, Tom Hemming.
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. Nature Genetics 2011 ;Volume 43.(1) p. 17-19
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35 Zegeye, Ephrem Debebe; Balasingham, Seetha; Lærdahl, Jon Kristen; Backe, Paul Hoff; Dalhus, Bjørn; Tønjum, Tone.
The M. tuberculosis RecG Enzyme Exhibits Helicase and ATPase Activities. Keystone Symposia on Molecular and Cellular biology; 2011-01-15 - 2011-01-20
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2010
36 Ambur, Ole Herman; Alfsnes, Kristian; Hovland, Eirik; Homberset, Håvard; Lærdahl, Jon Kristen; Frye, Stephan Alfons; Rognes, Torbjørn; Støen, Mari; Tønjum, Tone.
Mechanisms of neisserial transformation and the evolution of sexual reproduction. IPNC 2010; 2010-09-11 - 2010-09-17
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37 Hov, Johannes Espolin Roksund; Keitel, V; Lærdahl, Jon Kristen; Spomer, L; Ellinghaus, E; ElSharawy, A; Melum, Espen; Boberg, Kirsten Muri; Manke, T; Balschun, T; Schramm, C; Bergquist, A; Weismuller, T; Gotthardt, D; Rust, C; Henckaerts, L; Onnie, CM; Weersma, RK; Sterneck, M; Teufel, A; Runz, H; Stiehl, A; Ponsioen, CY; Wijmenga, C; Vatn, Morten H; Stokkers, PCF; Vermeire, S; Mathew, CG; Lie, Benedicte Alexandra; Beuers, U; Manns, MP; Schreiber, S; Schrumpf, Erik; Haussinger, D; Franke, A; Karlsen, Tom Hemming.
Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis. PLoS ONE 2010 ;Volume 5.(8) p. -
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2009
38 Cameron, Jamie; Holla, Øystein Lunde; Lærdahl, Jon Kristen; Kulseth, Mari Ann; Berge, Knut Erik; Leren, Trond Paul.
Mutation S462P in the PCSK9 gene reduces secretion of mutant PCSK9 without affecting the autocatalytic cleavage. Atherosclerosis 2009 ;Volume 203.(1) p. 161-165
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39 Dalhus, Bjørn; Lærdahl, Jon Kristen; Backe, Paul Hoff; Bjørås, Magnar.
DNA base repair - recognition and initiation of catalysis. FEMS Microbiology Reviews 2009 ;Volume 33.(6) p. 1044-1078
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40 krokeide, Silje Z.; Bolstad, Nils; Lærdahl, Jon Kristen; Bjørås, Magnar; Luna, Luisa.
Expression and purification of NEIL3, a human DNA glycosylase homolog. Protein Expression and Purification 2009 ;Volume 65.(2) p. 160-164
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41 Nordlund, Marianne Sparby; Warren, David; Lærdahl, Jon Kristen; Paus, Elisabeth.
Studies on Multiple Forms of proGRP in Serum from Small Cell Lung Cancer Patients. Tumour Biology 2009 ;Volume 30.(5-6) p. 265-275
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2008
42 Cameron, Jamie; Holla, Øystein Lunde; Berge, Knut Erik; Kulseth, Mari Ann; Ranheim, Trine; Leren, Trond Paul; Lærdahl, Jon Kristen.
Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion. The FEBS Journal 2008 ;Volume 275.(16) p. 4121-4133
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43 Cameron, Jamie; Holla, Øystein Lunde; Lærdahl, Jon Kristen; Kulseth, Mari Ann; Ranheim, Trine; Rognes, Torbjørn; Berge, Knut Erik; Leren, Trond Paul.
Characterization of novel mutations in the catalytic domain of the PCSK9 gene. Journal of Internal Medicine 2008 ;Volume 263.(4) p. 420-431
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44 Larsen, Elisabeth; Kleppa, Liv; Meza, Trine Johansen; Meza, Zepeda Leonardo; Rada, C; Castellanos, Cesilie Granum; Lien, Guro Flor; Nesse, Gaute; Neuberger, MS; Lærdahl, Jon Kristen; Doughty, RW; Klungland, Arne.
Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants. Cancer Research 2008 ;Volume 68. p. 4571-4579
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45 Ochran, Richard Acquaah; Lærdahl, Jon Kristen; Fernandez, Israel; Frenking, Gernot; Uggerud, Einar.
The steric effect in SN2 reactions.Is it possible to dissect it from electronic effects?. 19th IUPAC Conference on Physical Organic Chemistry; 2008-07-13 - 2008-07-18
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2007
46 Adzhubei, AA; Vlasova, AV; Hagen-Larsen, H; Ruden, Torgeir Andersen; Laerdahl, JK; Hoyheim, B; Lærdahl, Jon Kristen.
Annotated Expressed Sequence Tags (ESTs) from pre-smolt Atlantic salmon (Salmo salar) in a searchable data resource. BMC Genomics 2007 ;Volume 8.
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47 Dalhus, Bjørn; Helle, Ina Høydal; Backe, Paul Hoff; Alseth, Ingrun; Rognes, Torbjørn; Bjørås, Magnar; Lærdahl, Jon Kristen.
Structural insight into repair of alkylated DNA by a new superfamily of DNA glycosylases comprising HEAT-like repeats. Nucleic Acids Research 2007 ;Volume 35.(7) p. 2451-2459
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48 Hayes, Ben J.; Lærdahl, Jon Kristen; Lien, Sigbjørn; Moen, T; Berg, P; Hindar, Kjetil; Davidson, William S; Koop, Ben F.; Adzhubei, Alexei A; Høyheim, Bjørn.
An extensive resource of single nucleotide polymorphism markers associated with Atlantic salmon (Salmo salar) expressed sequences. Aquaculture 2007 ;Volume 265. p. 82-90
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49 Klungland, Arne; Lærdahl, Jon Kristen; Rognes, Torbjørn.
OGG1: From Structural Analysis to the Knockout Mouse. I: Oxidative Damage to Nucleic Acids. Springer Science+Business Media B.V. 2007 ISBN 9780387729732. p. 67-80
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2006
50 Adjoubei, Alexei Alexeevich; Lærdahl, Jon Kristen; Vlasova, AV.
preAssemble: a tool for automatic sequencer trace data processing. BMC Bioinformatics 2006 ;Volume 7.
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