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Showing results 1-50 of 72
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2023
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1. |
Lærdahl, Jon Kristen. The role of PGM1isoform 2 in PGM1-CDG: One step closer to genotype–phenotype correlation?. The Journal of Inherited Metabolic Disease (JIMD) 2023 ;Volume 46. p. 159-160 UiO
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Strøm, Thea Bismo; Asprusten, Emil Andreas; Lærdahl, Jon Kristen; Øygard, Irene Waal; Hussain, M. Mahmood; Bogsrud, Martin Prøven; Leren, Trond Paul. Missense mutation Q384K in the APOB gene affecting the large lipid transfer module of apoB reduces the secretion of apoB-100 in the liver without reducing the secretion of apoB-48 in the intestine. Journal of Clinical Lipidology 2023 ;Volume 17.(6) p. 800-807 OUS UiO
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Ølnes, Åsa Schawlann; Teigen, Marianne; Lærdahl, Jon Kristen; Leren, Trond Paul; Strøm, Thea Bismo; Bjune, Katrine. Variants in the CETP gene affect levels of HDL cholesterol by reducing the amount, and not the specific lipid transfer activity, of secreted CETP. PLOS ONE 2023 ;Volume 18.(12) OUS UiO
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2021
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Jiang, Xiaojun; Bergquist, Annika; Löscher, Britt-Sabina; Venkatesh, Geetha; Mold, Jeff E.; Holm, Kristian; Lærdahl, Jon Kristen; Skånland, Sigrid Strand; Maleki, Kimia T.; Cornillet, Martin; Tasken, Kjetil; Franke, Andre; Karlsen, Tom H.; Björkström, Niklas K.; Melum, Espen. A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis. Science Translational Medicine 2021 ;Volume 13.(582) p. - OUS UiO
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2020
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Backe, Paul Hoff; Lærdahl, Jon Kristen; Kittelsen, Lene Svendsen; Dalhus, Bjørn; Mørkrid, Lars; Bjørås, Magnar. Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the α-D-phosphohexomutase superfamily. Scientific Reports 2020 ;Volume 10.(1) p. - OUS UiO NTNU
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Saue, Trond; Bast, Radovan; Gomes, Andre Severo Pereira; Jensen, Hans-Jørgen Aa.; Visscher, Luuk; Aucar, Ignacio Agustín; Di Remigio, Roberto; Dyall, Kenneth G.; Eliav, Ephraim; Fasshauer, Elke; Fleig, Timo; Halbert, Loïc; Hedegård, Erik Donovan; Helmich-Paris, Benjamin; Ilias, Miroslav; Jacob, Christoph R.; Knecht, Stefan; Lærdahl, Jon Kristen; Vidal, Marta L; Nayak, Malaya K.; Olejniczak, Małgorzata; Olsen, Jógvan Magnus Haugaard; Pernpointner, Markus; Senjean, Bruno; Shee, Avijit; Sunaga, Ayaki; van Stralen, Joost N. P.. The DIRAC code for relativistic molecular calculations. Journal of Chemical Physics 2020 ;Volume 152.(20) p. - OUS UiT
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2019
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Berges, Natalia; Nawaz, Meh Sameen; Dahl, Tuva Børresdatter; Hagen, Lars; Bjørås, Magnar; Lærdahl, Jon Kristen; Alseth, Ingrun. Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform. PLOS ONE 2019 ;Volume 14.(11) p. - OUS UiO NTNU STO
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Lie-Jensen, Anette; Ivanauskiene, Kristina; Malerød, Lene; Jain, Ashish; Tan, Kia Wee; Lærdahl, Jon Kristen; Liestøl, Knut; Stenmark, Harald; Haglund, Kaisa. Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding. Current Biology 2019 ;Volume 29.(20) p. 3538-3548.e7 UiO OUS
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Strøm, Thea Bismo; Vinje, Terje; Bjune, Katrine; da Costa, Luís Teixeira; Lærdahl, Jon Kristen; Leren, Trond Paul. Lysosomal acid lipase does not have a propeptide and should not be considered being a proprotein. Proteins: Structure, Function, and Bioinformatics 2019 p. 440-449 OUS UiO
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Vinje, Terje; Lærdahl, Jon Kristen; Bjune, Katrine; Leren, Trond Paul; Strøm, Thea Bismo. Characterization of the mechanisms by which missense mutations in the lysosomal acid lipase gene disrupt enzymatic activity. Human Molecular Genetics 2019 ;Volume 28.(18) p. 3043-3052 OUS UiO
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2018
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Alexeeva, Marina; Guragain, Prashanna; Tesfahun, Almaz Nigatu; Tomkuvienė, Miglė; Arshad, Aysha; Gerasimaitė, Rūta; Rukšėnaitė, Audronė; Urbanavičiūtė, Giedrė; Bjørås, Magnar; Lærdahl, Jon Kristen; Klungland, Arne; Klimašauskas, Saulius; Bjelland, Svein. Excision of the doubly methylated base N4,5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins. Philosophical Transactions of the Royal Society of London. Biological Sciences 2018 ;Volume 373.(1748) NTNU UiO UIS OUS
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2017
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Strøm, Thea Bismo; Lærdahl, Jon Kristen; Leren, Trond Paul. Mutations affecting the transmembrane domain of the LDL receptor: Impact of charged residues on the membrane insertion. Human Molecular Genetics 2017 ;Volume 26.(9) p. 1634-1642 OUS UiO
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Søberg, Kristoffer; Moen, Line Victoria; Skålhegg, Bjørn Steen; Lærdahl, Jon Kristen. Evolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms. PLOS ONE 2017 ;Volume 12.(7) p. - OUS UiO
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2016
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Moen, Marivi Nabong; Fjær, Roar; Hamdani, El Hassan; Lærdahl, Jon Kristen; Menchini, Robin Johansen; Vigeland, Magnus Dehli; Sheng, Ying; Undlien, Dag Erik; Hassel, Bjørnar; Salih, MA; Khashab, HY; Selmer, Kaja Kristine; Chaudhry, Farrukh Abbas. Pathogenic variants in KCTD7 perturb neuronal K+ fluxes and glutamine transport. Brain 2016 ;Volume 139. p. 3109-3120 OUS UiO
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2015
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Dalhus, Bjørn; Backe, Paul Hoff; Lærdahl, Jon Kristen; Rowe, Alexander D.; Blicher, Pernille; Forstrøm, Rune Johansen; Rognes, Torbjørn; Bjørås, Magnar. Helse Sør-Øst Core Facility for Structural Biology and Bioinformatics. Norsk Biokjemisk Selskap Kontaktmøte 2015; 2015-02-13 - 2015-02-17 OUS UiO
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Strøm, Thea Bismo; Lærdahl, Jon Kristen; Leren, Trond Paul. Mutation p.L799R in the LDLR, which affects the transmembrane domain of the LDLR, prevents membrane insertion and causes secretion of the mutant LDLR. Human Molecular Genetics 2015 ;Volume 24.(20) p. 5836-5844 UiO OUS
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Zeissig, Sebastian; Petersen, Britt-Sabina; Tomczak, Michal; Melum, Espen; Huc-Claustre, Emilie; Dougan, Stephanie K.; Lærdahl, Jon Kristen; Stade, Björn; Forster, Michael; Schreiber, Stefan; Weir, Dascha; Leichtner, Alan M.; Franke, Andre; Blumberg, Richard S.. Early-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4. Gut 2015 ;Volume 64.(12) p. 1889-1897 UiO OUS
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2014
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Andersen, Pernille Strøm; Backe, Paul Hoff; Lærdahl, Jon Kristen; Rowe, Alexander; Forstrøm, Rune Johansen; Rognes, Torbjørn; Bjørås, Magnar; Dalhus, Bjørn. Helse Sør-Øst Core Facility for Structural Biology and Bioinformatics. NBS Contact meeting 2014; 2014-02-23 - 2014-02-26 OUS UiO
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Strøm, Thea Bismo; Tveten, Kristian; Lærdahl, Jon Kristen; Leren, Trond Paul. Mutation G805R in the transmembrane domain of the LDL receptor gene causes familial hypercholesterolemia by inducing ectodomain cleavage of the LDL receptor in the endoplasmic reticulum. FEBS Open Bio 2014 ;Volume 4. p. 321-327 OUS UiO
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Zegeye, Ephrem Debebe; Balasingham, Seetha; Lærdahl, Jon Kristen; Homberset, Håvard; Kristiansen, Per Eugen; Tønjum, Tone. Effects of conserved residues and naturally occurring mutations on Mycobacterium tuberculosis RecG helicase activity. Microbiology (Reading) 2014 ;Volume 160.(1) p. 217-227 UiO OUS
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2013
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Backe, Paul Hoff; Simm, Roger; Lærdahl, Jon Kristen; Dalhus, Bjørn; Fagerlund, Annette; Økstad, Ole Andreas Løchen; Rognes, Torbjørn; Alseth, Ingrun; Kolstø, Anne-Brit; Bjørås, Magnar. A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures. Journal of Structural Biology 2013 ;Volume 183.(1) p. 66-75 UiO OUS
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Balasingham, Seetha; Zegeye, Ephrem Debebe; Homberset, Håvard; Rossi, Marie; Lærdahl, Jon Kristen; Bohr, Vilhelm A.; Tønjum, Tone. Unique Features of DNA Helicases in Mycobacterium tuberculosis. EMBO Conference: Helicases and Nucleic Acid Translocases; 2013-08-04 - 2013-08-08 OUS UiO
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Balasingham, Seetha; Zegeye, Ephrem Debebe; Homberset, Håvard; Rossi, Marie; Lærdahl, Jon Kristen; Bohr, Vilhelm A.; Tønjum, Tone. Unique features of DNA repair helicases in Mycobacterium tuberculosis. GMM4: 4th Microbial Genome Maintenance Meeting; 2013-04-26 - 2013-04-29 OUS UiO
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Ellinghaus, David; Folseraas, Trine; Holm, Kristian; Ellinghaus, Eva; Melum, Espen; Balschun, Tobias; Lærdahl, Jon Kristen; Shiryaev, Alexey; Gotthardt, Daniel; Weismüller, Tobias J.; Schramm, Christoph; Wittig, Michael; Bergquist, Annika; Björnsson, Einar; Marschall, Hanns-Ulrich; Vatn, Morten H; Teufel, Andreas; Rust, Christian; Gieger, Christian; Wichmann, H.-Erich; Runz, Heiko; Sterneck, Martina; Rupp, Christian; Braun, Felix; Weersma, Rinse K.; Wijmenga, Cisca; Ponsioen, Cyriel Y.; Mathew, Christopher G.; Rutgeerts, Paul; Vermeire, Severine; Schrumpf, Erik; Hov, Johannes Espolin Roksund; Manns, Michael P.; Boberg, Kirsten Muri; Schreiber, Stefan; Franke, Andre; Karlsen, Tom Hemming. Genome-wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4. Hepatology 2013 ;Volume 58.(3) p. 1074-1083 UiO OUS UiB AHUS
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Krokeide, Silje Zandstra; Lærdahl, Jon Kristen; Salah, Medya; Luna, Luisa; Cederkvist, Fritjof Henning; Fleming, Aaron M.; Burrows, Cynthia J.; Dalhus, Bjørn; Bjørås, Magnar. Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin. DNA Repair 2013 ;Volume 12.(12) p. 1159-1164 OUS UiO
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Lærdahl, Jon Kristen; Nygård, Ståle; Jonassen, Inge; Hovig, Johannes Eivind; Petersen, Kjell; Drabløs, Finn; Willassen, Nils Peder; Våge, Dag Inge. The national technology platform for bioinformatics. NBS - Contact Meeting 2013; 2013-01-31 - 2013-02-03 NTNU UiB UiO UiT NMBU
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27. |
Søberg, Kristoffer; Jahnsen, Tore; Rognes, Torbjørn; Skålhegg, Bjørn Steen; Lærdahl, Jon Kristen. Evolutionary Paths of the cAMP-Dependent Protein Kinase (PKA) Catalytic Subunits. PLOS ONE 2013 ;Volume 8.(4) p. - UiO OUS
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28. |
Zegeye, Ephrem Debebe; Balasingham, Seetha; Lærdahl, Jon Kristen; Homberset, Håvard; Tønjum, Tone. Mycobacterium tuberculosis RecG is a helicase enzyme with broad DNA substrate specificity. EMBO Conference: Helicases and Nucleic Acid Translocases; 2013-08-04 - 2013-08-08 OUS UiO
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29. |
Zegeye, Ephrem Debebe; Balasingham, Seetha; Lærdahl, Jon Kristen; Homberset, Håvard; Tønjum, Tone. Mycobacterium tuberculosis RecG is a helicase enzyme with broad DNA substrate specificity. GMM4: 4th Microbial Genome Maintenance Meeting; 2013-04-26 - 2013-04-29 OUS UiO
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2012
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30. |
Balasingham, Seetha; Zegeye, Ephrem Debebe; Homberset, Håvard; Rossi, Marie; Lærdahl, Jon Kristen; Bohr, Vilhelm A.; Tønjum, Tone. Enzymatic Activities and DNA Substrate Specificity of Mycobacterium tuberculosis DNA Helicase XPB. PLOS ONE 2012 ;Volume 7.(5) p. - UiO OUS
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Balasingham, Seetha; Zegeye, Ephrem Debebe; Nilsen, Mariann; Homberset, Håvard; Rossie, Marie; Lærdahl, Jon Kristen; Bohr, Vilhelm A.; Tønjum, Tone. Delineating the functions of DNA repair helicases in Mycobacterium tuberculosis. Genome Dynamics in Neuroscience (GDN4)-Genome instability in aging and brain disease.; 2012-09-19 - 2012-09-22 OUS UiO
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32. |
Fladeby, Cathrine; Vik, Erik Sebastian; Lærdahl, Jon Kristen; Neurauter, Christine Gran; Heggelund, Julie Elisabeth; Thorgaard, Eirik; Andersen, Pernille Strøm; Bjørås, Magnar; Dalhus, Bjørn; Alseth, Ingrun. The Human Homolog of Escherichia coli Endonuclease V Is a Nucleolar Protein with Affinity for Branched DNA Structures. PLOS ONE 2012 ;Volume 7.(11) p. - UiO OUS
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Folseraas, Trine; Melum, Espen; Rausch, Philipp; Juran, Brian D.; Ellinghaus, Eva; Shiryaev, Alexey; Lærdahl, Jon Kristen; Ellinghaus, David; Schramm, Christoph; Weismüller, Tobias J.; Gotthard, Daniel Nils; Hov, Johannes Espolin Roksund; Clausen, Ole Petter Fraas; Weersma, Rinse K.; Janse, Marcel; Boberg, Kirsten Muri; Björnsson, Einar; Marschall, Hanns-Ulrich; Cleynen, Isabelle; Rosenstiel, Philip; Holm, Kristian; Teufel, Andreas; Rust, Christian; Gieger, Christian; Wichmann, H.-Erich; Bergquist, Annika; Ryu, Euijung; Ponsioen, Cyriel Y.; Runz, Heiko; Sterneck, Martina; Vermeire, Severine; Beuers, Ulrich; Wijmenga, Cisca; Schrumpf, Erik; Manns, Michael P.; Lazaridis, Konstantinos N.; Schreiber, Stefan; Baines, John F.; Franke, Andre; Karlsen, Tom Hemming. Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci. Journal of Hepatology 2012 ;Volume 57.(2) p. 366-375 UiO OUS UiB
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Korvald, Hanne; Falnes, Pål; Lærdahl, Jon Kristen; Bjørås, Magnar; Alseth, Ingrun. The Schizosaccharomyces pombe AlkB homolog Abh1 exhibits AP lyase activity but no demethylase activity. DNA Repair 2012 ;Volume 11.(5) p. 453-462 UiO OUS
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Søberg, Kristoffer; Larsen, Anja C V; Diskar, Mandy; Backe, Paul Hoff; Bjørås, Magnar; Jahnsen, Tore; Lærdahl, Jon Kristen; Rognes, Torbjørn; Herberg, Friedrich W.; Skålhegg, Bjørn Steen. Identification and Characterization of Novel Mutations in the Human Gene Encoding the Catalytic Subunit Calpha of Protein Kinase A (PKA). PLOS ONE 2012 ;Volume 7.(4) p. - UiO OUS
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Tveten, Kristian; Holla, Øystein Lunde; Cameron, Jamie; Strøm, Thea Bismo; Berge, Knut Erik; Lærdahl, Jon Kristen; Leren, Trond Paul. Interaction between the ligand-binding domain of the LDL receptor and the C-terminal domain of PCSK9 is required for PCSK9 to remain bound to the LDL receptor during endosomal acidification. Human Molecular Genetics 2012 ;Volume 21.(6) p. 1402-1409 OUS UiO
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Zegeye, Ephrem Debebe; Balasingham, Seetha; Lærdahl, Jon Kristen; Homberset, Håvard; Tønjum, Tone. Mycobacterium tuberculosis RecG binds and unwinds model DNA substrates with a preference for Holliday junctions. Microbiology (Reading) 2012 ;Volume 158.(Pt 8) p. 1982-1993 UiO OUS
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38. |
Zegeye, Ephrem Debebe; Balasingham, Seetha; Lærdahl, Jon Kristen; Homberset, Håvard; Tønjum, Tone. Mycobacterium tuberculosis RecG is a helicase enzyme with diverse DNA substrate affinities. EMBO Tuberculosis 2012: Biology, pathogenesis, intervention strategies.; 2012-09-11 - 2012-09-15 OUS UiO
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39. |
Zegeye, Ephrem Debebe; Balasingham, Seetha; Lærdahl, Jon Kristen; Homberset, Håvard; Tønjum, Tone. Mycobacterium tuberculosis RecG is a helicase enzyme with diverse DNA substrate affinities. Genome Dynamics in Neuroscience (GDN4)-Genome instability in aging and brain disease; 2012-09-19 - 2012-09-22 OUS UiO
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2011
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40. |
Holla, Øystein Lunde; Cameron, Jamie; Tveten, Kristian; Strøm, Thea Bismo; Berge, Knut Erik; Lærdahl, Jon Kristen; Leren, Trond Paul. Role of the C-terminal domain of PCSK9 in degradation of the LDL receptors. Journal of Lipid Research 2011 ;Volume 52.(10) p. 1787-1794 OUS UiO
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Holla, Øystein Lunde; Lærdahl, Jon Kristen; Strøm, Thea Bismo; Tveten, Kristian; Cameron, Jamie; Berge, Knut Erik; Leren, Trond Paul. Removal of acidic residues of the prodomain of PCSK9 increases its activity towards the LDL receptor. Biochemical and Biophysical Research Communications - BBRC 2011 ;Volume 406.(2) p. 234-238 OUS
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Korvald, Hanne; Moe, Anne Margrethe Mølstad; Cederkvist, Fritjof Henning; Thiede, Bernd; Lærdahl, Jon Kristen; Bjørås, Magnar; Alseth, Ingrun. Schizosaccharomyces pombe Ofd2 Is a Nuclear 2-Oxoglutarate and Iron Dependent Dioxygenase Interacting with Histones. PLOS ONE 2011 ;Volume 6.(9) p. - OUS UiO
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43. |
Lærdahl, Jon Kristen; Korvald, Hanne; Nilsen, Line; Dahl-Michelsen, Kristin; Rognes, Torbjørn; Bjørås, Magnar; Alseth, Ingrun. Schizosaccharomyces pombe encodes a mutated AP endonuclease 1. DNA Repair 2011 ;Volume 10.(3) p. 296-305 OUS UiO
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44. |
Melum, Espen; Franke, Andre; Schramm, Christoph; Weismüller, Tobias J.; Gotthardt, Daniel; Offner, Felix A.; Juran, Brian D.; Lærdahl, Jon Kristen; Labi, Verena; Björnsson, Einar; Weersma, Rinse K.; Henckaerts, Liesbet; Teufel, Andreas; Rust, Christian; Ellinghaus, Eva; Balschun, Tobias; Boberg, Kirsten Muri; Ellinghaus, David; Bergquist, Annika; Sauer, Peter E.; Ryu, Euijung; Hov, Johannes Espolin Roksund; Wedemeyer, Jochen; Lindkvist, Björn; Wittig, Michael; Porte, Robert J.; Holm, Kristian; Gieger, Christian; Wichmann, Heinz-Erich; Stokkers, Pieter C.F.; Ponsioen, Cyriel Y.; Runz, Heiko; Stiehl, Adolf; Wijmenga, Cisca; Sterneck, Martina; Vermeire, Severine; Beuers, Ulrich; Villunger, Andreas; Schrumpf, Erik; Lazaridis, Konstantios N; Manns, Michael P.; Schreiber, Stefan; Karlsen, Tom Hemming. Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. Nature Genetics 2011 ;Volume 43.(1) p. 17-19 OUS
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Zegeye, Ephrem Debebe; Balasingham, Seetha; Lærdahl, Jon Kristen; Backe, Paul Hoff; Dalhus, Bjørn; Tønjum, Tone. The M. tuberculosis RecG Enzyme Exhibits Helicase and ATPase Activities. Keystone Symposia on Molecular and Cellular biology; 2011-01-15 - 2011-01-20 OUS UiO
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2010
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46. |
Ambur, Ole Herman; Alfsnes, Kristian; Hovland, Eirik; Homberset, Håvard; Lærdahl, Jon Kristen; Frye, Stephan Alfons; Rognes, Torbjørn; Støen, Mari; Tønjum, Tone. Mechanisms of neisserial transformation and the evolution of sexual reproduction. IPNC 2010; 2010-09-11 - 2010-09-17 OUS UiO
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47. |
Hov, Johannes Espolin Roksund; Keitel, V; Lærdahl, Jon Kristen; Spomer, L; Ellinghaus, E; ElSharawy, A; Melum, Espen; Boberg, Kirsten Muri; Manke, T; Balschun, T; Schramm, C; Bergquist, A; Weismuller, T; Gotthardt, D; Rust, C; Henckaerts, L; Onnie, CM; Weersma, RK; Sterneck, M; Teufel, A; Runz, H; Stiehl, A; Ponsioen, CY; Wijmenga, C; Vatn, Morten H; Stokkers, PCF; Vermeire, S; Mathew, CG; Lie, Benedicte Alexandra; Beuers, U; Manns, MP; Schreiber, S; Schrumpf, Erik; Haussinger, D; Franke, A; Karlsen, Tom Hemming. Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis. PLOS ONE 2010 ;Volume 5.(8) p. - UiO AHUS OUS
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2009
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48. |
Cameron, Jamie; Holla, Øystein Lunde; Lærdahl, Jon Kristen; Kulseth, Mari Ann; Berge, Knut Erik; Leren, Trond Paul. Mutation S462P in the PCSK9 gene reduces secretion of mutant PCSK9 without affecting the autocatalytic cleavage. Atherosclerosis 2009 ;Volume 203.(1) p. 161-165 OUS UiO
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49. |
Dalhus, Bjørn; Lærdahl, Jon Kristen; Backe, Paul Hoff; Bjørås, Magnar. DNA base repair - recognition and initiation of catalysis. FEMS Microbiology Reviews 2009 ;Volume 33.(6) p. 1044-1078 UiO OUS
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50. |
krokeide, Silje Z.; Bolstad, Nils; Lærdahl, Jon Kristen; Bjørås, Magnar; Luna, Luisa. Expression and purification of NEIL3, a human DNA glycosylase homolog. Protein Expression and Purification 2009 ;Volume 65.(2) p. 160-164 OUS
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